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Aptamers work much the same way as the antibodies used in assays. The difference is that researchers can make their own custom aptamers more easily than engineering the antibodies.

The problem is even this hypothesis (IDO2 dysfunction in immune cells), this still doesn't explain ME/CFS symptoms at all. There is too much missing in their hypothesis at the moment. I also don't agree with the reasons given for not publishing their data. Reading between the lines, it almost...

I wish such articles would clearly communicate that antibody titre is not efficacy! The delay substitutes quality for quantity and therefore may be detrimental in the long term.

I'm not convinced about this "98.5%" reliability without published data for a population cohort. Serological tests rarely have such high sensitivity. You might have nothing to worry about.

But the body doesn't have such a system. There is no system of body-wide energy homeostasis, there is only peripheral signals telling the brain not all is well in some particular part of the body. The closest to such a system is the blood glucose regulation system (which is relatively simple...

I agree, this study could have been really interesting. Measures of 2 day CPET and peripheral blood flow would have been interesting, though that wouldn't have helped the recruitment figures very much.

That is my experience of the rapid fatigability when exercising. The power we expect to be there is not there at all and any effort to push harder is also associated with a rapid increase in pain (which diminishes quickly if I back off). The remarkable part is not all of us have that...

It improves performance when fatigued, so I'd argue it is 'more good'. Or rather, a beneficial response, rather than a perpetuating factor. This is a normal response to the stimulation of the metabo-sensitive muscle afferents and is associated with 'central fatigue'. I strongly doubt this is...

TBH, I feel more energetic and focus on symptoms less when suffering from psychological stress. Of course I avoid such states as I don't enjoy it mentally, but...

Of course, because no one cares about the "social" part of biopsychosocial.

Such "certification" or a "vaccination passport" should not be used for anything other than being required for international travel. Those who are immunised can still be infected and can still spread the virus.

Some people are reporting worsening. (though this still doesn't imply anything specific about the pathology)

When the system is working normally, it leads to more oxygen available by the cardiopulmonary system for a given level of motor drive as I stated in my previous post. Perhaps I wasn't clear, there are many potential primary causes (some of which I mentioned), but there is some overlap in the...

The "common pathology" is that all fatiguing disorders are associated with central fatigue. We know this because the TMS, EMG studies regardless of pathology all have very similar results when fatigue is deliberately induced - central fatigue (EMG), reduced cortical excitability (TMS)...

Yes, it will never be a specific measure. The effect (reduced repeatability) is due to reduced cortical excitability (central fatigue) and is common to all fatiguing disorders, because it is mediated by peripheral afferent feedback - it doesn't matter if the illness is cancer related fatigue...

It's worse when they propose hypotheses that should already be ruled out due to ME/CFS research.

What you are saying is not mutually exclusive. In principle, defects of the fibroblasts can lead to defects in the collagen networks.

The irony is that it isn't society in general that has such prejudice (that causes stigma), it is a subgroup of medical practitioners that perpetuates it.

This sounds like a terrible idea. There are plenty of (what should be) innocuous topics by which to attract threats (that aren't annoying bullshit). Posting about how motorists endanger the lives of cyclists for example.

Claiming that the CSI predicts CWP and FM caseness, therefore it has "construct validity" is nonsense, it is circular logic. For them to claim construct validity, they have to demonstrate a high sensitivity and specificity for predicting objective pain related phenomena (eg actually measure...