Covid-19 vaccines and vaccinations

Results of the Com- COV study are out ( mix and match vaccines) and show that mixing and matching increases the risk of unpleasant side effects.

https://www.cnbc.com/2021/05/12/covid-study-finds-mixing-vaccines-
increases-risk-of-adverse-reactions.html

In a peer-reviewed research letter published in The Lancet international medical journal on Wednesday, researchers of the trial reported that when given at a four-week interval, both of the alternating vaccine schedules of the Oxford-AstraZeneca vaccine and the Pfizer-BioNTech vaccine induced more frequent reactions following the second dose than the standard non-mixed schedules.

“Whilst this is a secondary part of what we are trying to explore through these studies, it is important that we inform people about these data, especially as these mixed-doses schedules are being considered in several countries,” Matthew Snape, associate professor in Paediatrics and Vaccinology at the University of Oxford, said in a statement.

KEY POINTS
  • Preliminary data from the so-called “Com-COV” study found that volunteers receiving alternating doses were more likely to develop mild to moderate symptoms.
  • Some of those symptoms reported among participants receiving a mixed vaccine schedule included chills, fatigue, feverishness, headache, joint pain, malaise, muscle ache and pain at the injection site.
  • The adverse reactions were found to be short-lived and there were no other safety concerns.

So.....my decision to stay with AZ once I had had v1 seems to have paid off. My GP referred me to hospital to have Pf for v2 but I was uncomfortable changing v type without any evidence as to effects so I made a last minute decision to stay with AZ. My reactions have been lengthy and severely unpleasant but I am done for now and glad to be v'd.
 
Sam Walter said:
Merged thread

AZ vaccination and no antibodies

Hi. I have ME (start 1995, poster child for Canadian definition and for ME ICC). I got my first AZ jab in early March. After seven weeks I had antibody tests done (renowned testing centre, 98.5% reliability of test) for both IGg and IGm antibodies, using a phlobotomist.
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I'm not convinced about this "98.5%" reliability without published data for a population cohort. Serological tests rarely have such high sensitivity.

You might have nothing to worry about.
 
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Dr. Dana Mazo, hospital epidemiologist and assistant professor of medicine at Mount Sinai Hospital in New York.

She explained that in some instances, one type of vaccine can increase the effectiveness of another.

“There are two different types of pneumococcal vaccines that have different mechanisms of action, and in certain situations we recommend boosting one with the other,” she said.

According to Bhayani, scientific data has shown that getting several vaccines at the same time does not cause any chronic health problems.

When every new vaccine is licensed, “it has been tested along with the vaccines already recommended,” he added.
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https://www.healthline.com/health-n...#Not-the-first-time-vaccine-mixing-is-attempt

I've read that they've also had better outcomes mixing vaccines for the Ebola virus.
 
In a new paper seen by Reuters and expected to appear on medRxiv on Friday ahead of peer review, researchers found that among 175 people ages 80 to 99, those who got their second dose at 12 weeks had antibody responses that were 3.5 times higher than those who got it after three weeks. Antibodies are only one part of the immune system, and vaccines also generate T cells that fight infections. The peak T cell responses were higher in the group with a three-week interval between doses, and the authors cautioned against drawing conclusions on how protected individuals were based on which dosing schedule they received.
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Delayed 2nd Pfizer/BioNTech shot boosts antibodies in elderly; COVID-19 obesity risk higher for men (msn.com)
 
I have questions about all this.

CDC Just Clarified These Mask Rules for Everyone

Dr. Rochelle Walensky, director of the CDC. Bolding and sentence breaks mine.

I have questions about each of those bolded points.

"Science really evolved in two weeks", did it to the point that this is a good decision to do at this very moment?

The vaccines are working against our variants. Is that true?

If you're vaccinated you can't transmit that infection to other people. Is this true tooo?

"We're lucky to be there with the science that we have" - hmmm.

Anyone up-to-date on the science on the the questions I have below that she speaks of below? What is being said and not being said and considered.


https://www.msn.com/en-us/health/me...ied-these-mask-rules-for-everyone/ss-BB1gNhdv

"Let's celebrate this moment," said Walensky on This Week. "We're in a place in this pandemic, cases have been coming down in more than a third, just in the last two weeks. We have vaccine now across this country, widely available for anyone who wants it.
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And we now have science that has really just evolved even in the last two weeks that demonstrates that these vaccines are safe, they are effective.
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They are working in the population just as they did in the clinical trials, that they are working against our variants, that we have here circulating in the United States.
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And then if you were to develop an infection, why even if you got vaccinated, that you can't transmit that infection to other people."
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We were going to get to a place in this pandemic where vaccinated people were going to be able to take off their mask. We're lucky to be there with the science that we have, and now we have to take this foundational step that is completely based in science and understand what it means as we open the entire country."
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Edit: punctuation
 
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Mij said:
The first made in Canada vaccine from Medicago.

Plant-derived COVID vaccine candidate with GSK pandemic adjuvant is moving into Phase 3 clinical trials today
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Abstract
Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being deployed, but the global need greatly exceeds the supply, and different formulations might be required for specific populations. Here we report Day 42 interim safety and immunogenicity data from an observer-blinded, dose escalation, randomized controlled study of a virus-like particle vaccine candidate produced in plants that displays the SARS-CoV-2 spike glycoprotein (CoVLP: NCT04450004). The co-primary outcomes were the short-term tolerability/safety and immunogenicity of CoVLP formulations assessed by neutralizing antibody (NAb) and cellular responses. Secondary outcomes in this ongoing study include safety and immunogenicity assessments up to 12 months after vaccination. Adults (18–55 years, n = 180) were randomized at two sites in Quebec, Canada, to receive two intramuscular doses of CoVLP (3.75 μg, 7.5 μg, and 15 μg) 21 d apart, alone or adjuvanted with AS03 or CpG1018. All formulations were well tolerated, and adverse events after vaccination were generally mild to moderate, transient and highest in the adjuvanted groups. There was no CoVLP dose effect on serum NAbs, but titers increased significantly with both adjuvants. After the second dose, NAbs in the CoVLP + AS03 groups were more than tenfold higher than titers in Coronavirus 2019 convalescent sera. Both spike protein-specific interferon-γ and interleukin-4 cellular responses were also induced. This pre-specified interim analysis supports further evaluation of the CoVLP vaccine candidate.
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https://www.nature.com/articles/s41...ce=twitter&utm_medium=social&utm_content=orga
 
I’m curious to know what those of you who have had 2 doses of vaccines are now comfortable doing? Have you changed your behaviour much since having two doses? It’s been 2 weeks since my second dose of vaccine and I’m undecided about what to do. I’m feeling slightly under pressure to mix with family but not sure I’m comfortable with that yet (especially now they’re all relaxing their behaviours considerably, in line with the relaxation of the lockdown rules)...
 
It's 3 weeks since both my daughter and I had our second dose of AZ. We currently have a family member, who lives too far away for just dropping in, staying for 3 days. They have also had both doses (of Pfizer vaccine), live alone and have only been mixing with others outdoors, and did a lateral flow test the day before coming here. I'm not entirely comfortable with it, but think I have to get used to it or we'll never see anyone else, since we are too sick go out and visit people and socialise outdoors.
 
I am 5 weeks post AZ2. I was affected so severely by the vaccine that my life is more restricted than prior to vaccination.

I have seen my daughter and family outside for a picnic. The noise from that event a couple of weeks ago ( there was a drum playing in the distance which caused me to retreat to the car) caused a severe relapse: dreadful tinnitus, inability to tolerate being spoken to, inability to use phone.

I am still nowhere near my prior level.
 
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JaneL said:
I’m curious to know what those of you who have had 2 doses of vaccines are now comfortable doing? Have you changed your behaviour much since having two doses? It’s been 2 weeks since my second dose of vaccine and I’m undecided about what to do. I’m feeling slightly under pressure to mix with family but not sure I’m comfortable with that yet (especially now they’re all relaxing their behaviours considerably, in line with the relaxation of the lockdown rules)...
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I read this morning that 3 seniors living in LTC homes died after contracting variant (S. Africa) after being fully vaccinated.

I'm concerned that some pwME might not have a robust immunity response to x2 vaccines.
 
@Binkie4 how awful :( i hope it all improves very soon

Trish said:
It's 3 weeks since both my daughter and I had our second dose of AZ. We currently have a family member, who lives too far away for just dropping in, staying for 3 days. They have also had both doses (of Pfizer vaccine), live alone and have only been mixing with others outdoors, and did a lateral flow test the day before coming here. I'm not entirely comfortable with it, but think I have to get used to it or we'll never see anyone else, since we are too sick go out and visit people and socialise outdoors.
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My bolding. Yes this is also going to be my approach. I cant carry on in total isolation & once i am double dosed, i will be mixing (sensibly) with those who are also doubled dosed and tested. For those who are living/working in front line occupations i will be doing masks & distancing inside though
 
My close friend is electing not to get vaccinated. She is in her 40s and read something her friends sent her, which I refused to delve into. I stick to the Twiv podcasts by virologists, immunologists, and an MD, where papers are critiqued on the issues.

I feel very strongly pro-vaccination and I wonder what we will talk about now, how to skirt the issue.

Our community risk is labeled moderate risk, though restaurants and movie theaters are open with restrictions.
 
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JaneL said:
I’m curious to know what those of you who have had 2 doses of vaccines are now comfortable doing? Have you changed your behaviour much since having two doses? It’s been 2 weeks since my second dose of vaccine and I’m undecided about what to do. I’m feeling slightly under pressure to mix with family but not sure I’m comfortable with that yet (especially now they’re all relaxing their behaviours considerably, in line with the relaxation of the lockdown rules)...
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It is 3 weeks since my second jab. I don't get out much but I had to go for a blood test so I took the opportunity to go shopping. It was about 11.00 o'clock in the morning so everything was quiet. I visited 2 shops and got some hand cream and 6 t shirts for warm days so I was pleased.

The vaccine helped make the decision (I did not have a problem with either injection) but the number of cases is low in my area so I wanted to get some clothes before they started going up again. they are bound to increase as restrictions are eased.
 
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