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  1. Snow Leopard

    Does Functional Somatic Symptoms Measurement Differ Across Sex and Age? Differential Item Functioning in Somatic Symptoms.., 2021, Acevedo-Mesa et al

    It's funny how they often name questionnaires that focus on measuring mental disorders in a non-descript manner such as "Composite International Diagnostic Interview".
  2. Snow Leopard

    Covid-19 vaccines and vaccinations

    That is the study I cited in the post above and well, the claim they have discovered the reason is misleading at best...
  3. Snow Leopard

    Covid-19 vaccines and vaccinations

    @Jonathan Edwards Have you seen this? https://www.researchsquare.com/article/rs-558954/v1 I think the title is extremely misleading since no evidence of mimicry has been provided and a study already ruled out molecular mimicry due to the spike protein. I have previously proposed...
  4. Snow Leopard

    Psychosomatic symptoms questionnaire (PSQ-39): a psychometric study among general population of Iranian adults, 2021, Heidari et al

    An AUC of 0.78 is crap and will lead to a very high rate of false positives and negatives.
  5. Snow Leopard

    EXHAUSTION: A History, 2016, Schaffner

    Chapter 10 completely mischaracterises the experiences of ME/CFS patients and Nasim Marie Jafry in particular who was unaware that her work had been mischaracterised in the book until I told her about it. Nasim also had prior interactions with the author and tried to explain such experiences to...
  6. Snow Leopard

    The biology of coronavirus COVID-19 - including research and treatments

    The sensitivity and specificity of sniffer dogs for something like COVID is poor, I suspect it's promotion, is so that it can be used as a deterrent.
  7. Snow Leopard

    IDO2 gene mutations - SNPs

    Of the data that I have (for myself): rs10109853 C/C rs4736794 A/A ¯\_(ツ)_/¯
  8. Snow Leopard

    Study on the Relationship between the miRNA-centered ceRNA Regulatory Network and Fatigue, 2021, Yang et al

    While I encourage novel hypotheses, I don't find the hypotheses terribly compelling given the current evidence. I'd encourage the authors to conduct in-depth empirical studies if they are serious about the hypothesis. Unfortunately, in the narrative review, the authors haven't clearly...
  9. Snow Leopard

    Covid-19 vaccines and vaccinations

    By the way, it is being claimed that the recent PHE AstraZeneca data may be an 'underestimate' as many of those who contracted COVID had only had their booster within 2-4 weeks of contracting COVID and therefore they may not have had enough time to develop 'full immunity'. That claim is not...
  10. Snow Leopard

    Actimetry Studies

    The key with actimetry is not that it is an either/or, but used in addition to other measures, including measures of symptoms and level of cognitive activity.
  11. Snow Leopard

    Covid-19 vaccines and vaccinations

    Here is some data: Note the sample sizes are relatively small, meaning the figures are somewhat uncertain. The previously reported 80% claim was based on combined AZ/Pfizer results...
  12. Snow Leopard

    Covid-19 vaccines and vaccinations

    Maybe. I can't find the latest PHE data. The claim is likely to be based on retrospective estimates of infection comparing for a non-randomised (and thus biased) non vaccinated vs. the vaccinated cohort for those who showed up at a testing clinic or hospital and tested positive (I'd wager almost...
  13. Snow Leopard

    Covid-19 vaccination experiences

    Does he have a fever? Sounds like a form of delirium.
  14. Snow Leopard

    COVID-19 symptoms over time: comparing long-haulers to ME/CFS, Jason et al, 2021

    I agree. Having said that, studies do often show that patients self-report improvements from baseline, in the first few years. https://pubmed.ncbi.nlm.nih.gov/15699087/
  15. Snow Leopard

    Covid-19 vaccination experiences

    Sorry to hear you haven't been doing well since the vaccine! I will say however, that such symptoms after just a vaccine is interesting in terms of suggesting pathology of Dysgeusia/Anosmia!
  16. Snow Leopard

    Can vaccines cure ME/CFS or Long Covid?

    Some of the researcher comments weren't bad, but I agree it should be emphasised that such surveys are always of low-quality and not generalisable.
  17. Snow Leopard

    Post-COVID Syndrome: An Insight on Its Pathogenesis, 2021, Maltezou et al

    None of this is particularly insightful, but I guess the narrative review could be useful for anyone unfamiliar with the field. The lack of discussion of parallels with ME, CFS and other post-viral syndromes is indicative of the lack of broader picture thinking...
  18. Snow Leopard

    "Exercise in a pill" - potential for ME/CFS?

    https://en.wikipedia.org/wiki/GW501516 A PPAR delta receptor agonist is an... interesting idea. It has clear metabolic effects and stimulates PPARGC1A which is a regulator of mitochondrial biogenesis. The problem is we still don't understand the underlying causes and it may actually exacerbate...
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