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A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection Abstract Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic1,2,3,4. Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic...

Highlights A group of trials with trust concerns had major impacts on the results of systematic reviews and clinical guidelines. They substantially impacted effect sizes and influenced the conclusions and recommendations drawn. There is a need for a greater focus on the trustworthiness of...

Link to published version here Preprint Abstract To understand the roles of acute phase viral dynamics and host immune responses in PASC, we enrolled 136 participants within 5 days of their first positive SARS-CoV-2 real-time PCR. Participants self-collected nasal specimens up to 21 times...

As far as I can see there's a ton of data and it seems every bit of data is easily accessible open source.

Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID Abstract While immunologic correlates of COVID-19 have been widely reported, their associations with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of PASC presentations...

Quite suprising to me nature has made the announcement that the article soon won't be paywalled anymore. In the meantime it can be accessed via...

The immunology of long COVID Abstract Long COVID is the patient-coined term for the disease entity whereby persistent symptoms ensue in a significant proportion of those who have had COVID-19, whether asymptomatic, mild or severe. Estimated numbers vary but the assumption is that, of all...

I couldn't agree more. I have absolutely no problem with their project, it's great to see it and fantastic that they received funding for it. The problem is presenting often very vague hypotheses or ideas as facts, sometimes even clearly wrong things as facts and even doing so with a "Dr." in...

Sure. Here it is:

https://sci-hub.wf/10.1136/bmj.h2087

Currently no information. Both Rob Wüst and Jeroen den Dunnen are somehow a bit involved in this bachelor student gimmick project. Jeroen den Dunnen has found some kind of autoantibodies associated to Long-Covid and has received a grant to study these in ME/CFS...

The ARD in Germany, which is something like an equivalent of the BBC in the UK, did a documentary on Long-Covid https://www.daserste.de/information/ratgeber-service/hirschhausens-check-up/sendung/hirschhausen-und-long-covid-100.html which also included a recent follow-up...

I think it's important to emphasize that this is not a collaboration of researchers. These are bachelor students who've just started their studies and were given the chance to "play around a bit".

I agree that, that is the argument proposed by the OMF or by patients. However, if that were the case it would in my opinion be very unethical. If you have a solid biomarker, which is something you know for certain after 4 years, you put all your efforts into that. Engineers aren't...

Original title in Dutch: Studenten onderzoeken het effect van immuunsysteem Long-COVID-patiënten op spiercelfunctie...

The details of mechanisms being described here are way over my head. To me it is very clear that the nanoneedle has flunked. They published on this potential biomarker 4 years ago. Nowadays, the OMF is funding projects that are looking for biomarkers in ME/CFS and Long-Covid. One doesn't waste...

Here's the new pre-proof version: https://www.sciencedirect.com/science/article/pii/S2213231723001970. Are we sure Scheibenbogen's team is connected, I can't see any connection? Patients were recruited from the Parkstad Clinic in Amsterdam, what is this? I can only find a dermatologist with...

Would such a psychologist exist that overshadows Wessely and is as invested in him in the topic? I don't think so. We're basically saying that a knighted and world-wide leading psychologist, head of his departement, former president of the Royal Society of Medicine, Fellow of the Royal Society...

Quite interesting work from a group looking at slighty different things than all other groups. Good to see.

Overall Merel Hellemons makes a great impression on me. It's great to see that Hellemons was part of the recent evaluation of the Knoop CBT for Long-Covid trial https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciad399/7210772. It's very dissapointing to see that the...