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I don't get this. We all have EBV so how can having had it be a risk factor? My mum looked at this decades ago and some people with autoimmune disease are EB negative so you do not even need it. EBV switches on B cells like billy-oh but we have known that for ages. B cell switching on goes wrong...

This remains the case but thanks to @Allele for asking.

Why doesn't Dr Sharpe call me out for my conflict of interest? Is it that as a professor at Oxford University he is used to arguing with those he considers lesser mortals and prefers to stick with that? (I found Oxford a bit stuffy as a student so moved to the University of London.) Pretty...

I hope everyone is aware that omeprazole and cimetidine and completely different classes of drug. They affect acid production in quite different ways. The 1200mg dose of cimetidine, or even the 1600mg dose is very standard as far as I can see. It is not in any meaningful sense 'high'.

Except that maybe all it shows is that deconditioning is not the proximate cause of inactivity in people who think they have ME but don't actually have it because all the people with real ME would not have volunteered to take part, having a false belief that they could not cope with GET. The...

Hey, you are supposed to be the fons et origo here! I couldn't possibly comment.

My understanding is that it was a deliberate sop to AfME who were very disappointed when the trial they thought was deigned to prove pacing works turned out to be designed to show it didn't work. The letter from Moira Henderson of the DWP reveals the doubletalk going on.

Sharpe is in a sense making a valid point. PACE was just a trial. The psychological relationships within a trial are completely different from outside trials. The treatments being tested were based on psychological relationships. So there is no reason to extrapolate the results to real life. In...

What I find strange is that Dr Sharpe seems not to understand very basic concepts like conflict of interest. There is no conflict of interest in raising money to be able to put a point of view if you openly indicate that you are raising money to put that point of view. A CONFLICT of interest is...

I think Twist has got this in a muddle. Reiter's syndrome and reactive arthritis are defined differently and have some overlap and some not. But a doctor would not say they are distinct clinical entities. They would say there is a spectrum and that the most typical cases fit both definitions...

Second, study quality needs to be actively incorporated into the presentation of conclusions. Third, and perhaps most importantly, the approach of NICE needs to be more critical. Seeming to set the bar too low, or lower for psychological therapies, can only raise doubts about rigour and...

I think you are missing the point @Keela Too. Of course it is sensible to find the dietary mix that is easiest to starve on (reduce calories on). But that will depend on the individual. They can work that out for themselves if they know what the calorie counts are. The point is that there is no...

Sorry @Keela Too , but it makes no difference to the advice if there is. You cannot change the number joules in a carbon-hydrogen bond. Lots of things will affect appetite but the physics remains the same. If a person is overweight they will get back to normal weight if they restrict calories...

Well that does not make a lot of sense to me. If you need to reduce intake you need to reduce it. Fat has the highest concentration of calories of any food type by far. There is no question of replacing anything missing with low carb. You just eat less. If your weight is normal and you reduce...

Not in my department. The story never changed. It is basic metabolic sense and it works if stuck to. But the key thing IS to get calories down because the insulin resistance is determined by weight. Low carb helps from day to day but it makes no difference to the insulin resistance in the long...

Yes but my medical textbook said that for free in 1974. Using fasting and low carb diet has always been the treatment for type 2 diabetes, since I was a student. I would never have thought of doing anything else. Nobody needs to do a blog about this. It is what students are supposed to write in...

All very true but what is this guy selling: Intensive Dietary Management Program So that is why he is dissing the pharma industry. (Maybe he is a chum of Ben Goldacre) He's the same as all the others.

The largest notebook is 0.99 m² (10.74 ft²), achieved by Nuco International Ltd. (UK), as measured at the Business Design Center in Islington, London, UK, on 26 April 2016. It took 4 men 5 hours to bind the book and it weighs almost 40kg! The notebook was displayed at the London Stationery Show...

From what I can see on Wikipedia I have a suspicion that organisations like Greenpeace may have morphed rather in the way that the Revolutionary Communist Party and SMC have morphed. The original people started going off in weird directions. That may of course be spin but I am not sure. It may...

Twaddle again I would say. How about this bit: To avoid conflation of roles, all stakeholders should agree role descriptions at the beginning of a research study. This can help clarify expectation in large multidisciplinary teams for all research partners. Yes, it should be made clear that...