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It might be interesting to see how many times internet sites carrying the PACE paper (PubMed etc) have been downloaded recently. It might turn out that rather a lot of people have read the paper!

I don't see how anyone can charge for a Chalder fatigue score. You might have to pay for software to calculate the score I suppose if you wanted to get scores rapidly in clinic. However, I don't think these scores are of any real relevance to routine clinical use. They might be useful for audit...

Nobody

I don't think there is an 'art of reviewing'. Reviewing is just giving an honest opinion. It is not unreasonable that senior people are asked to review if you have a system as at present. My idea is that you do not have formal prepublication review. You post your paper on your university website...

Holton claims that the picture here looks simplistic, but we do not yet have evidence that would give us sufficient reason to abandon it. Or to even take it seriously? The more I think about these things the more it all seems similar to homeopathy. The idea of treating like with like, although...

I prefer double unblinded review and publication of the review and reviewer attached to the paper. Then if the reviewer says anything stupid or irrelevant or vindictive it is apparent for all to see. PLOS One already has something a bit like this.

I think we wait to hear what the final scoping agenda is. We also wait for adverts asking for applications for committee places.

There is a difference between putting something in the guideline as a positive suggestion and what physicians are free to use if they wish. I don't think mestinon should be suggested specifically but if a physician feels they are justified in using it they can now and will still be able to...

No, I think not. B12 has been used for decades as the panacea placebo and I would bet my shirt that is all it is. It is the perfect placebo - being a vitamin sounds healthy and natural and being an injection makes it powerful. Q10 is pretty similar. I can think of no plausible scientific reason...

As I understand it the PACE authors position is consistent on this. They did not recognise a specific 'disease' called ME and were not trying to study it. They were interested in chronic fatigue that was not explained by some other illness like MS. The Oxford criteria were designed to detect...

I am not sure what big differences are being referred to. I have not seen anything that has stood up to replication well and am not actually aware of anything major from Komaroff. Is there a link to this?

I think that is moot in practice. For an infectious disease like Lyme or hepatitis an appreciation of infectious cause is going to have a big impact on what is included as sensible advice.

Perhaps the obvious choice is Stuart Watson who works with Julia Newton.

Yes, I think Edwards was a major influence on the construction of the Wessely-Chalder speculation. Edwards was de facto head of Medicine at UCL around 1982-4 because the official head bowed out of any administrative function. He worked on muscle physiology in the context of training. I think he...

Tending to show is not enough, though. There are tens of thousands of papers tending to show this or that in any number of diseases and the great majority of them never turn out to mean anything useful. Peter Barry works in intensive care paediatrics. He will be used to sifting out the studies...

I realise that the IOM framed things in this way. However, the truth is that we have nothing that provides firm evidence for a pathological mechanism in ME. I wait to hear about convincing evidence for this mechanism or that but so far there is nothing tangible. There really isn't. And the chair...

Agreed but if the fifth point is that they turn out not to be deconditioned despite ME then the first point is a bogus argument. And it is only the first point that would have made sense anyway!

It's in the original paper laying out the plan to use CBT: J R Coll Gen Pract. 1989 Jan;39(318):26-9. Management of chronic (post-viral) fatigue syndrome. Wessely S, David A, Butler S, Chalder T. The full text is free I am pretty sure. On page two he is giving reasons why it is a mistake to...

Well he jumped between two universes in a single paragraph in the 1989 paper, so he is pretty consistent. He was justifying something, I forget what. His first reason was the dangers of not exercising - causing deconditioning. And his fifth reason was that PWME are not deconditioned. He didn't...

Yes @Suffolkres, I think there are some legal issues here, and rightly so. Even on my Bird Club Wiki site I am asked not to mention who else was present at a certain time and place. When people go to meetings they do not necessarily expect that to be put on the net. Certain people one can be...