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Symptoms? I have symptoms? :wtf:

References? I have looked into this for two and a half decades. Look up any enzymology reference text. D6D and D5D (delta desaturases) are regulated by reduced glutathione status, though other things are needed too. Reduced glutathione is depleted in our brains, probably as a result of oxidative...

This is not a guaranteed effect of anything. It requires omega-6 fat substrate, and reasonable levels of glutathione, and is easily blocked. The other sleep center was only discovered last year, in the brain stem. We know next to nothing about it. I think it was discussed on this forum.

Light related circadian setting was only one out of maybe fifteen different factors that I found more than a decade ago in the scientific literature. This is just about the SCN as well, we know nothing about the other sleep center. I forget the details now, but most of these factors are known to...

Ummm, non 24 occurs in blind people and its not genetic. So the neurologist is wrong. Sleep is regulated by two sleep centers, and requires active hormone synthesis (PGD2), and lots of other mechanisms. There is also a second sleep center in the brain stem but we only just discovered it and know...

I was like that for a decade before I hit this new phase of the problem.

Non 24 is about the tendency to keep a sleep cycle a bit longer than 24 hours. However I do find it can be like 16 hours or 32 hours, just tends to be 25 hours. What has been happening to me the last few years is a sleep cycle of four to six hours. I am awake for a few hours, then asleep for a...

If sufficient information were published instead of withheld then FOIs would be much less necessary. This is failure on behalf of the researchers to publish sufficient information to judge their research to a high standard. Open data is important in order to deal with potential issues in...

Yes, its the same flaw. However the sentence implies the solution. Do not rely on subjective outcomes, use objective outcomes, then base any claim of success or failure on the objective outcomes. This does not remove the need for sound methodology however.

Let us be fair though, we should not be requiring this study meet the standards of mature research. Its early days. What we can do is say something like "OK, there is a possibility there is something to this, please do a follow-up study with better methodology. " Most possibilities that are...

For perhaps a decade I did have swollen lymph nodes. Then they went away. Then about a decade ago I came down with a chronic sore throat. I am still waiting for that to go away.

Let us suppose this test has a high sensitivity, though current ME testing has sensitivity to 95% which is clearly superior, though more expensive. It still suffers from specificity, which is the bane of a lot of testing. We cannot be sure the findings are not due to other issues. Edit: The...

Big pharma does this frequently using comparison groups, not placebo. Give the wrong drug, in the wrong dose, or with the wrong protocol, and compare it to your drug.

Probably NICE guidelines for patients. If it was Oxford then we can totally discount the study. Does anyone know which diagnostic criteria for sure? Current diagnostic techniques are fundamentally flawed, so I agree I cannot have confidence. Where was the validation using CCC or ICC? The issue...

This relates to another common medical mistake. ME cannot be proven. The physiological problems in ME patients do have tests though. So what is wrong to a great extent can be demonstrated by tests. No disease diagnostic test does not mean no physiological tests. The issue with ME diagnostic...

The concept of gold standard is a study that best controls for bias and error. It can still be wrong, have other biases, or be fraudulent.

This is one of my major concerns. One of the reasons, in my view, that diseases like depression, fibro, and ME have no cures, aside from complexity, is this confusion between a symptom and a disease. Its a category mistake. Depression, for example, is not a disease, its a symptom of disease...

I was not posting about this I think. However its known to happen. I hear about it from time to time.

There is risk in CPET technology. It is totally unsuitable for severe patients. Its why we need a validated blood test or other investigatory marker. However a great many patients have used CPET. Nearly all recover in a week or two from what I have read. This level of risk is also found in...

Sadly this is often the case, and nearly always the case in psychopsychiatry. With CPET data for ME or strictly defined CFS the problems are not found in sedentary controls. I do not know if this includes long term bedbound patients. Its why I think comparison of blood findings and exercise...