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I thought it might be useful to go through the main arguments against the review, to see if these make sense and if they would impact the results. I’m numbering the arguments to make it easier to discuss them. 1) Pooling different fatigue questionnaires I think it might be true that it’s...

So they should test positive for a Western blot, a standard test to detect acute Lyme disease? I suspect many chronic Lyme disease patients do not meet this requirement (or they had the test several times until it had a positive result). I suspect in many cases the diagnosis is made based on...

@duncan Honest question (I'm no expert at this subject) Suppose patients have no recollection of a tick bite, the erythema migrans rash or Lyme disease at the beginning of their illness and they present wich symptoms that meet case definitions of CFS or ME. What basis could there be for saying...

I agree with that, but I also think there might be a real problem of overdiagnosis. Belgium is probably a good example of this. A few years ago the main ME/CFS expert in the country, Kenny De Meirleir, started diagnosing pretty much all his ME/CFS patients with chronic Lyme disease on the basis...

Do you mean this: "We have added three new studies in this updated review (Jason 2007; Wearden 2010; White 2011)"? This is a statement that was already in the previous version. These studies (Wearden et al. 2010 is the FINE trial and White et al. 2011 the PACE trial) were added to the review...