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The paper mentions voltage-gated sodium channels (Nav) as the primary target of the toxins. Downstream effects include an increase in intracellular calcium concentration by various mean, including calcium influx through transient receptor potential (TRP) channels. A blood transcriptomic study...

Killian L’Herondelle,1 Matthieu Talagas,1,2 Olivier Mignen,3Laurent Misery,1,2 and Raphaele Le Garrec1,* (French researchers) Abstract Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused by the consumption of tropical and subtropical fish contaminated with...

@Snow Leopard, have you seen this? In your cornucopia of papers, you seem to be focusing on some of the molecules and processes that are thought to be important in long term ciguatera. There are quite a lot of recent papers on the pathology of ciguatera, as, with climate change, it seems to...

Good try, but I don't think that was the paper I was thinking of. I'll try to find it.

From this 2018 study Background on ciguatera: Long-term symptoms with similarities to ME/CFS (there are other accounts of symptoms that sound very similar indeed): They think they have identified a mechanism for 'long-lasting neurological changes': On upregulated ephrins and axon...

I've been interested in ciguatera for a while, because exposure to the ciguatoxin can cause long term symptoms that have a lot of similarities with those of ME/CFS. And also because early on in my illness I saw a paper by a Japanese researcher that found similarities in protein expression, I...

I wonder if you could take photos when it is good and bad, not many days apart, perhaps with a tape measure? They might help when you are trying to convince doctors. I get some swelling that comes and goes - I don't wear my watch or rings now - although not as pronounced as what yours sounds...

This study, related to cortisol, has been moved to its own thread: Epigenetic Modifications and Glucocorticoid Sensitivity in ME/CFS, 2017, de Vega, Vernon et al

With the finding of 12,608 differentially methylated sites between ME/CFS patients and healthy controls, this team might be churning out papers for a while, if this paper is any guide. They suggest 13 of the 12,608 are associated with glucocorticoid sensitivity, implicating processes in...

(the rest of the abstract) Methods: We examined the DNA methylome in peripheral blood mononuclear cells (PBMCs) of a larger cohort of female ME/CFS patients using the Illumina HumanMethylation450 BeadChip Array. In parallel to the DNA methylome analysis, we investigated in vitro glucocorticoid...

One issue is that some protein biomarkers might only be different when the body is stressed. For example, one team reported finding that, in healthy people, plasma Cys34 changed to its oxidised form when muscles were worked, but it didn't in people with ME/CFS. Surely there will be proteins...

I haven't read the paper yet but it looks like this group are well aware that the small sample in this study means that this is just a start. I hope they get more funding for this. With the potential for possibly two or more illnesses being included under the ME/CFS label, it would be...

I'm glad you're on the job @Simone. It's dreadfully frustrating. As you and Sean say, Norman Swan comes across as a very credible source of information and he has influence. I wonder why he has the blind spot, if he is friends with Lloyd or Hickie, or had a bad encounter with an ME/CFS...

I think personal stories do have a place in professional journals. For example, there was the recently posted article by a GP who had 6 years seeking, and eventually getting, a diagnosis for a medical condition. She talked about what it was like to be labelled with a functional disorder, and...

The abstract is quite vague. It starts by dividing persistent physical symptoms into those that are medically unexplained and those that are not: It does not, however, create a separate term for persistent physical symptoms that are medically unexplained. So, the rest of the abstract could...

Maybe someone could ask Vicky Whittemore at the NIH?

Does anyone know anything about the consultation? @Simon M

Initially Grenada controlled cases with a lockdown. After an exponential increase in cases in the first half of December 2020, the country applied a partial lockdown to bring it under control again. Arrivals from the UK are currently banned. I'm not saying that Garner caused the Grenada...

What sort of things do the charity standards require, jonathan_h?