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Age, CP calcium volume and cortical BPnd were correlated. Sex and the disease/control groups were not. So, none of the disease groups had more CP calcification or cortical BPnd than might have been expected for the ages of the groups. They conclude that CP calcium volume is an easy way to...

The 2022 study quantifies the amount of calcification in the CP and the size of the CP and compares them to "cortical BPnd" which is a measure of the concentration of translator protein (TSPO). They say TSPO is expressed by activated microglia - and so I think activated microglia is assumed to...

Regarding the calcification, this image might help with understanding where the calcification occurs. Clinical Imaging of Choroid Plexus in Health and in Brain Disorders: A Mini-Review, 2019 At the bottom of the image is a capillary with red blood. At the top is the blue CSF, and then the...

Just in the meantime, some background on the choroid plexus, which forms the blood-CSF barrier: From Development and functions of the choroid plexus–cerebrospinal fluid system, Nature 2015 The choroid plexus (ChP) is a secretory tissue found in each of the brain ventricles, the main function of...

I'm gobsmacked. The researchers used completely different methods to measure pain for the chronic pain and the fibromyalgia groups. They did this because the hospital's rheumatologists asked them to. So, there's no way to compare the level of pain in each group or the change in pain after the...

I did a 2xCPET as part of a study, but with a 48 hour gap, not 24 hours. I did the first CPET, and then had PEM for several/more? hours that night. When I say PEM, I mean, feeling terrible, like I had a bad flu, with a feeling of my body being crushed, glands up, absolutely had to lie down...

Abstract Introduction: Little is known about risk factors for both Long COVID and somatic symptoms that develop in individuals without a history of COVID-19 in response to the pandemic. There is reason to assume an interplay between pathophysiological mechanisms and psychosocial factors in the...

I'm sure that you are. My view is that the physicians are stumbling around in the dark in much the same way as those of us who assume we have ME/CFS. In terms of convincing yourself, I found tracking my symptoms for a while so that I understood them better was helpful. And hearing about the...

The 2xCPET won't give you objective proof that you aren't "crazy". Or even proof that you have ME/CFS. It won't prove that you do or do not have PEM. If your 2xCPET is abnormal, you won't know for sure that you have ME/CFS. If it's normal, you won't know for sure that you don't have ME/CFS...

What transparency of analysis? The authors took the one or two hour interviews of 13 young women and then chatted about them amongst themselves, applying their prejudices and beliefs to what they had heard as they did so. They then concocted two narratives which illustrated the ideas they felt...

That seems to be Susannah Pick writing that - and here's the link to our thread on that referenced 2020 paper: Dissociation and interoception in functional neurological disorder, 2020, Pick et al It's exactly as you might imagine, that paper (at least as far as the abstract goes) does not...

Here's the link - it wasn't super easy to find: Expressions of Interest for the Office for Disability Issue's Nominations Database

We've created a thread for the RECOVER Initiative, an NIH programme of Long Covid research. A number of posts that were in other threads have been moved there. USA: The RECOVER Initiative - programme of Long Covid research funding There is also a tag 'Recover Initiative'.

Endless scope for cherry picking, not to mention selection bias in the people who are participants in the study, and the huge potential for researchers to influence subjective reports of 'in the moment' experiences. It's truly bizarre and deeply sad that the Medical Research Council thought...

:) My submission on that draft filled up nearly 50 pages. I've just received word that I've been appointed as a member of this committee, the National Advisory Committee on Health and Disability Ethics. The 'Ethical guidance for a Pandemic' document that is being prepared is one project...

It certainly is bad, but I expect there are quite a few disasters in medicine competing for the title. This has been commented on before, and perhaps it's just the translation, but a 'psychosomatic physician' doesn't sound like a particularly desirable label. Perhaps one just imagines one is...

A reminder that today is the last day for submissions. If you have a little time, perhaps you can pick just a couple of the points above and make a submission. The evidence received by the Inquiry in that Hansard record is awful - lots of multi-disciplinary holistic care and graded activity...

Nice explanation @Willow, thank you. I was actually more bothered by the image of the stamp that appears at that Osteospermum link I posted above, where the Forever was crossed out. 'USA not forever' seemed even more worrying than 'USA forever'. I puzzled about it for a while, checking that...

Thanks @rvallee, a good reminder that the deadline for submissions to this inquiry is coming up.

175. Khanpour Ardestani S, Karkhaneh M, Stein E, et al. Systematic review of mind-body interventions to treat myalgic encephalomyelitis/chronic fatigue syndrome. Medicina. 2021;57(7):652. doi:10.3390/medicina57070652 Thread here: Systematic Review of Mind-Body Interventions to Treat Myalgic...