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with the majority adhering to the research protocol (n=7;53.8%). According to what measure? Not to mention that 53.8% is the bare majority (7/13), thus almost as many didn't adhere to it. The last session focused on the long-term planning that would allow the participants to envision their...

Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility Gut. 2026 Jan 20 PMID: 41558814 DOI: 10.1136/gutjnl-2025-337059 Cristian Díaz-Muñoz, et al. Open Access Abstract Background: Genetic...

Sooner these ultra-rich idiots take their one-way trip to Mars the better for humanity.

I would be amazed if it was not hardcore 24/7 lobbying. Never believe these clowns have conceded anything, no matter what they say, you only have to look at what they do. Their fundamental beliefs about ME/CFS have not changed one iota. If anything they just get more and more entrenched and...

Thanks a bunch, RFK Jr, and your batshit insane obsessions. What a legacy. :facepalm:

:sneaky:

There are some weird people in the world. Such as those who need a scientific justification to eat chocolate without feeling guilty. :rolleyes:

This.

This is probably correct. At least some of what we might currently perceive as random is just insufficient understanding of the causal relationships driving it all. This. In fact we do it naturally, without planning, or motivating by an external force.

This possibility was, of course, a bit of snark. If it were true then we would be self-healing instantly all the time and hence would not be sick!

Given the right adjustments, people with ME/CFS, in all its categories of severity, possess capabilities that could be revived to a reasonable and necessary level of function for an elevated experience of life. As the social model of disability would argue, people with ME/CFS are not disabled...

Very good letter, @InitialConditions. Thank you. :thumbup:

Indeed. The correct response to the oil pressure warning light coming on and the temperature gauge starting to rise is not to press the accelerator harder. I hope this paper is an anomaly. A (maybe even the) critical piece of evidence for lack of deconditioning (at least substantial enough to...

Which version? :devilish:

Thresholds are a less problematic concept for me, as long as it is understood that they are dynamic and to some extent chaotic; not easy to spot, not a simple marker to avoid, more like a fuzzy space with a lot of inherent unpredictability; and not crossing a threshold doesn't mean you are...

I increasingly get the feeling that in general there are now sufficient clues sitting there in front of us, but we don't have the right conceptual framework yet to make the connections and draw a good research map.

Has he ever considered gathering sufficient robust evidence?

What most strikes me about the BPS movement is its lack of humility. They are utterly certain they are correct, and are instead entirely focused on how to market it to the lay public, the profession, and the political class.

Convalescence is a concept and term that could be useful for us. Good chance, I think, that a lot more patients would do considerably better in the long term, even if not actually fully recovering, if they were both diagnosed early, and allowed to convalesce adequately in the early stages.

It is staring the medical profession and governments right in the face, and yet... *crickets*