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  1. V.R.T.

    Mast Cell Activation Syndrome (MCAS) - discussion thread

    Thanks - I do also get strange fluctuations in body temperature, and overreactions to heat and cold. So perhaps that makes sense. I have never had any reactions like this to chilli before covid/severe ME (i deteriorated and then got covid shortly after and got even worse) and was a big fan of...
  2. V.R.T.

    Mast Cell Activation Syndrome (MCAS) - discussion thread

    I have allergic type symptoms too since becoming severe/getting covid, and hands going bright red after I eat high histamine foods like curry. I decided to take it seriously after two occasions where I ate a heavily fermented food (kimchi on one occasion and yellow bean paste on another) and had...
  3. V.R.T.

    Is the key pathology of ME/CFS in bone marrow?

    I'm sorry to hear Jo continues to be so unwell. Her unpublished data sounds interesting, but I'm curious - how does a pathology involving antibodies to signalling proteins differ from a classic autoantibody pathway?
  4. V.R.T.

    Article: HPDL deficiency

    All of this for one child, and yet all of the children sick with ME and LC are shunned and put through 'treatment' programs that just make them sicker. The dichotomy is crushing.
  5. V.R.T.

    Trial Report Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy, 2025, Ruan et al

    Anyone got any word on whats going on there? Last I heard Hwang et al were moving ahead with a small drug trial...
  6. V.R.T.

    Who are currently the best ME/CFS researchers?

    That thread is definitely a bummer! I don't know whether you saw these comments from JE though: So there is some hope in amongst all the bleak truth of that thread. There is also the daratumumab phase 2 study just beginning in Norway which looks quite promising. There are several threads...
  7. V.R.T.

    Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment, 2016, Blank +

    Totally understandable! I remember trying to do academia with ME, it was hard going. Hope the collaboration requests are fruitful!
  8. V.R.T.

    Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment, 2016, Blank +

    How goes your quest for muscle samples? Appreciate you may not be able to divulge everything but curious to know how your work is progressing.
  9. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    So having reread this I think JE is talking about the inital Decode HLA analysis. And that it could well have picked out those connections but whatever it did pick up was discovered to be a computational hallucination so we were left with the DQ link. And I checked and DR is the HLA protein...
  10. V.R.T.

    Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment, 2016, Blank +

    The lupus connection again...
  11. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    Could you possibly clarify what you mean by this for laypeople like myself? Is DR the HLA that DQ is usually linked to but wasnt in DecodeME?
  12. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    Don't we have to wait for the HLA analysis before we can conclude that they didn't show up? I thought the whole point of that is that the normal GWAS method can miss a lot about HLA.
  13. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    This is what i was trying to get at earlier
  14. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    Yes, I misread the abstract somewhat!
  15. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    My brain fog is bad right now but couldn't these results suggest weak binding with all antigens rather than pathogen specific ones? As in immune dysfunction not viral persistance as the driver.
  16. V.R.T.

    Air Purifier for COVID

    I have the bigger one of that and I'm quite happy with it!
  17. V.R.T.

    HLA and pathogens in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infection conditions, 2025, Georgopoulos et al

    HLA-C and DQB1! Does the conclusion they come to about persistent herpesvirus line up with the data? It doesn't look like they determined the binding affinity to other types of antigen. Edit: my mistake, missed the first part of that last paragraph.
  18. V.R.T.

    Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID, 2025, Liu et al.

    Eight individuals? Is that normal for this type of study? Sounds like they only studied eight acute covid patients and extrapolated about long covid from there? Is this a valid approach? This sounds like the sort of vicious cycle and the sort of treatment we have been speculating about on...
  19. V.R.T.

    Immune cell communication networks and memory CD8+ T cell signatures sustaining chronic inflammation in COVID-19 and Long COVID, 2025, Liu et al.

    What does this mean? Have we seen any of these genes before?
  20. V.R.T.

    Clare Gerada: influence on UK medical practice and ME/CFS management

    Its absolutely insane how many NHS staff still believe covid isnt airborne. This was Feb 2020 but could easily be Feb 2025.
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