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Discussion from author here: Lots of work/findings on endothelial cells / function recently, including in POTS. I have no idea what they are / do. :-$

https://www.nature.com/articles/s41598-021-89834-9 ABSTRACT Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease characterized by unexplained debilitating fatigue. Although the etiology is unknown, evidence supports immunological abnormalities, such as persistent...

Is this not it, further down that thread: PACE Trial application to MRC for funding in 2002

Yes, I guess it's a sort of a front for her advocacy work. She has used the term 'Alliance' in various forms to put on events etc in the past.

I wonder if non-US organisations can submit evidence?

I wonder if this is the closest thing the US has to the NICE Guideline. I remember reading about this a couple of years ago. There was concern that the Pacific Northwest Evidence-Based Practice Center was being awarded the contract with no competitive bidding process. MEAction teamed up with...

It's not really a formal organisation as such. I know Opal, the author of the book, through the CMRC PAG, which she has been involved with for many years.

Tweets from the study lead, Ben Goldacre:

https://www.medrxiv.org/content/10.1101/2021.05.06.21256755v2 Abstract Background: Long COVID is a term to describe new or persistent symptoms at least four weeks after onset of acute COVID-19. Clinical codes to describe this phenomenon were released in November 2020 in the UK, but it is not...

Does anyone know who is funding this? Can't find info on site.

I think they'd have found that correlation by now if it existed. Pariante's talk at the 2018 CMRC conference included reference to the finding of low cortisol levels in ME/CFS patients and he then compared it with high cortisol found in depressed patients.

I'm not an expert but I think you might be correct.

This looks highly suspect (and I'm not just talking about the website's aesthetics / design). The Myhill mitochrondia test comes to mind....

I don't think we learned much. As I said to David Tuller yesterday—and others may disagree, but this is my personal opinion—I think there's enough biomedicine and biology in Pariante's work for it to be taken seriously. Any work on brain inflammation and central fatigue may prove important to...

Edit [Pariante interview] starts at 2:19:00 - the segment is much longer and involves a long Covid patient before Pariante.

They really don't! But thanks.

Did anyone manage to listen to this? I can't seem to find an option on the BBC London site to listen back.

I can't respond to any comments this afternoon, as I need a break. Maybe this evening. A reminder that the FOI materials are linked in the post. Unfortunately, there are lots of emails in separate files and they are not in chronological order. The filenames of key emails are referenced in the blog.

It is not 100% clear that the guideline panel has gone down the route of this further analysis to address GRADE indirectness, but I'm 90% sure from the emails that they have. As I state on the blog post, I feel this is primarily to address stakeholder comments, and not to make significant...