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  1. InitialConditions

    Incidence and Prevalence of Post-COVID-19 Myalgic Encephalomyelitis: A Report from the Observational RECOVER-Adult Study, 2024, Vernon +

    This seems to suggest that ~20% of the RECOVER cohort had PEM but did not meet ME/CFS criteria. And that ~11% of the cohort have ME/CFS owing to COVID-19, yet don't have long covid...?
  2. InitialConditions

    Global Prevalence of Long COVID, its Subtypes and Risk factors: An Updated Systematic Review and Meta-Analysis, 2025, Hou et al.

    I don't understand how this paper has defined long covid. "Our inclusion criteria are as follows: (1) human study population with confirmed COVID-19 diagnosis through polymerase chain reaction (PCR) test, antibody test, or a clinical diagnosis; (2) index date of first test/diagnosis, date of...
  3. InitialConditions

    Global Prevalence of Long COVID, its Subtypes and Risk factors: An Updated Systematic Review and Meta-Analysis, 2025, Hou et al.

    Abstract Importance Updated knowledge regarding the global prevalence of long COVID (or post-COVID-19 condition), its subtypes, risk factors, and variations across different follow-up durations and geographical regions is necessary for informed public health recommendations and healthcare...
  4. InitialConditions

    The science of craniocervical instability and other spinal issues and their possible connection with ME/CFS - discussion thread

    Article about a woman with ME/CFS and diagnosed CCI and tethered cord. https://www.thesun.co.uk/health/32671565/mum-skull-spine-daughter-nursery-glandular-fever/
  5. InitialConditions

    Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle‑serving nerves and spinal cord, 2025, Drosen et al.

    The first few sentences of this paper put me right off, as does the tweet about 'groundbreaking work' from one of the authors. These are supposed to be ME/CFS experts. Do they really think you only get PEM after being on a treadmill, or is it the case that the authors write poorly....? Who knows!
  6. InitialConditions

    Inactivation of ATG13 stimulates chronic demyelinating pathologies in muscle‑serving nerves and spinal cord, 2025, Drosen et al.

    Abstract Chronic muscle fatigue is a condition characterized by debilitating muscle weakness and pain. Based on our recent finding to study the potential effect of mTOR on ATG13 inactivation in chronic muscle fatigue, we report that biweekly oral administration with MHY1485, a potent inducer of...
  7. InitialConditions

    UK: Long COVID SOS News

    The GP leaflet links to a 'PESE booklet', which is available here: https://www.shu.ac.uk/advanced-wellbeing-research-centre/projects/an-information-booklet-to-help-manage-chronic-fatigue-brought-on-by-covid-19. It's just a booklet on general chronic fatigue, and doesn't even mention ME, CFS...
  8. InitialConditions

    Use of EEfRT in the NIH study: Deep phenotyping of PI-ME/CFS, 2024, Walitt et al

    Jeannette Burmeister has written a new thread after receiving a response to her complaint:
  9. InitialConditions

    Have there been any high-profile critiques of open-label, subjective-measures BPS randomised trials? If not, why not?

    I was thinking about this just the other day. It seems the ME/CFS community is the only place where this is discussed and challenged. That's not good enough. Why is the rest of medicine/clinical science silent?
  10. InitialConditions

    Anidulafungin (IV antifungal)

    Could it have been the antibiotics (assuming these were administered concurrently) or even steroids, which it seems were given at that time? These improvements in ME/CFS after antibiotics seem to be documented quite frequently in the patient community.
  11. InitialConditions

    [Case Report] Treatment of Long Covid with Enoxaparin, 2025, Wright, Kell, Pretorius, Putrino

    The patient in this study is the first author. I'm not sure that it is good practice to do this without mentioning the fact.
  12. InitialConditions

    Preprint Immune Cell Exhaustion and Apoptotic Markers in Major Depressive Disorder: Effects of in Vitro Cannabidiol Administration, 2024, Rachayon et al

    He has been discussed at length on the forum. He's a one-man paper mill, and I wouldn't trust that anything he writes is of value.
  13. InitialConditions

    Review Interventions for the management of long covid post-covid condition: living systematic review, 2024, Zeraatkar, Flottorp, Garner, Busse+

    Yeah, the submission took a while for me. And they don't give confirmation, except the green message. Hopefully they add it after Christmas.
  14. InitialConditions

    News from Mexico, Central America and the Caribbean

    I think this is just a copy of a Reuters article from a month ago: https://www.reuters.com/business/healthcare-pharmaceuticals/many-long-covid-patients-adjust-slim-recovery-odds-world-moves-2024-11-14/
  15. InitialConditions

    Is there a treatment for bruxism (teeth grinding)?

    I suffer with noctural bruxism, and have done for at least six years. I have written about it here on other threads. There is no cure. There are certain things you can do to help lessen the issue. Minimizing stress is probably up there, because often this is related to stress. You should also...
  16. InitialConditions

    United Kingdom: Action for ME (AfME) news

    Does anyone know anything about getting this funded — a proposal in the works, for example?
  17. InitialConditions

    Review Defining and measuring long COVID fatigue: a scoping review 2024 Thomas et al

    Yes, I looked up the author and she is a PhD student. Her co-authors — some of whom will likely be her PhD supervisors — should be making sure the paper is not littered with trivial, and more important, mistakes. They should have raised concerns with the journal that Reviewer 1 wasn't doing...
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