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Think the main conclusion was (or should be) that there's a lack of overlap between what these studies found. Even with a lenient false discovery rate (FDR) of 10%, there were only 2 study that pointed to similar genes. In this case it was MT-RNR1 and MT-RNR2 which came up in the Raijmakers (N=...

Thanks very much for your detailed analysis @Hutan . I know you previously had a closer look at the HPA-axis findings in ME/CFS. Did you notice any consistency regarding a blunted ACTH response? I came across several older studies that reported this by using different stressors to test the ACTH...

Wrote a summary of this protocol on social media: 1) The protocol for the MELLOW study (ME/CFS + Long COVID Longitudinal Omics and Women’s Health) has been published. It will look in-depth at the influence of hormones and the menstrual cycle in both diseases using home sampling. 2) The...

Bumped into this old study that might be relevant to the CRH-autopsy findings. Abnormalities in response to vasopressin infusion in chronic fatigue syndrome M Altemus 1, J K Dale, D Michelson, M A Demitrack, P W Gold, S E Straus Abstract Several neuroendocrine studies have suggested...

Wasn't thinking much to be honest. Just bumped into this older PET study when looking for something else. Didn't know about it before. Interested in hearing what others make of it.

An old PET scan on 10 CFS patients that found reduced binding to serotonin receptors in the hippocampus. Was wondering if it might be relevant.

Abstract Background: Research from neuroendocrine challenge and other indirect studies has suggested increased central 5-HT function in chronic fatigue syndrome (CFS) and increased 5-HT1A receptor sensitivity. We assessed brain 5-HT1A receptor binding potential directly using the specific...

Thanks, I certainly missed it.

Do they explain this in this paper? Could you or someone else quote the passage, can't seem to find it.

Supplementary file 4 is the TIMES final version. Attaching it here so that people can more easily acces it.

Yes and out of 58 questions only 1 asks about PEM. In comparison there are 9 questions about cognitive problems, 7 about pain, 6 about sleep, etc. So this does not seem in proportion. It also only takes 1 symptom to be completely disabled. So counting how many symptoms a person has a based on...

Thanks. Looks like the Pariante and Ng projects weren't really about ME/CFS, the McArdle project only published an abstract, and the Nutt project only a trial registration?

Thanks. I'm aware of Newton's research and the Pariante study but the others do not ring a bell. EDIT: did any decent studies come out of the grants to Dr. Ng and Prof McArdle?

Old BMJ article about MRC funding for ME/FCS with comments from Stephen Holgate and John Williams. Researchers get £1.6m to look at scientific basis of chronic fatigue syndrome | The BMJ From a historical perspective: was wondering which teams got funded and which papers came out of this? Does...

I don't really get what the point is of articles like this in a newspaper. It doesn't get much info across about Long Covid, ME/CFS or its treatment. It's mainly just about this person being able to scuba dive again.

The Dr. Sanders who promotes exercise is Lisa Sanders, medical director of Yale’s long Covid multidisciplinary care center.

Quote from the article:

So apparently we now have 4 teams doing a trial of low-dose Naltrexone in ME/CFS: - Marshall-Gradisnik at Griffith University, Australia - Yarred Younger at University of Alabama, USA - David Systrom at Brigham and Women's Hospital, USA - Luis Nacul at the University of British Columbia, Canada...

Just speculating here but perhaps it has to be a certain kind of infection, like a severe viral infection, that ME/CFS patients are less likely to get because of social isolation. But most cytokines already seem normal or low in ME/CFS while the symptoms signal runs full strength. So perhaps...

Bit of a long shot but was speculating that if the neural pathway that induces symptoms is constantly on, even without the cytokines that normally trigger it, then perhaps artificially raising the 'feeling bad' cytokines such as interferons might help to reset or recalibrate? If ME/CFS...