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Question for the more knowledgeable. If a transcription factor itself and multiple genes with that transcription factor in transcription factor binding sites for their promoters and enhancers are all found (as they seem to have been here) would that cascade and magnify any effect? I don’t know...

I didn’t see a thread about SOX6, apologies if I missed it SOX6 seems interesting as it is not only a peak in LocusZoom itself but also a Transcription Factor Binding Site mentioned in Genehancer data for promoters and enhancers for many (well most) other genes in the DecodeME candidate gene...

Wasn’t sure where to put this, but here’s the info from my script (mentioned above) for all the DecodeME candidate genes, ready to paste into posts and check. I’ll work through seeing if there’s anything interesting but if others want to join in too, the more the merrier. There’s the same dats...

That reminds me I saw some pretty cheap ANC headphones at RicherSounds. Sorry can’t recommend any as I can’t use them, but saw them in an email I got and the PowerLocus Moonfly are £39 and Nothing CMF £69.

I’ve just read that the Sussex and Surrey ICBs are merging, what that will mean for commissioning of services I do not know. This story from November https://www.bbc.co.uk/news/articles/cdxr700z27do

There seems little solid evidence of this no. And certainly none in ME/CFS. People talk about the theory of viral persistence in both but there’s never been any proof of it and no anti viral treatments have worked AFAIK. That page says It sounds like he doesn’t have much faith in interferon...

Is anyone aware of any of the ‘specialist teams’ delivery domiciliary care? Certainly the issue near me is they sre only commissioned for mild/moderate and do their reformed CBT/GET thing so nobody takes responsibility for us. They seem to acknowledge the problems of severe patients but don’t...

Promoters and Enhancers info. Like elsewhere a curated rather than complete list. Nothing over the line of statistical significance but a few things that could be interesting including both promotors and enhancers away from the main protein coding region. Only one with info on regulatory...

I made a script to pull out some data to make it easy to compare to locuszoom and then looked at the top 15 and manually went through deleting those which weren’t clearly/very significant hits. It seems to be mainly the promoter locations. Gene: CA10 - carbonic anhydrase 10 Location...

Thanks for the tip! Good to know I’m not talking nonsense! And nice to start to understand it a bit more.

Thanks! The highlighting doesn’t seem very touchscreen friendly unfortunately. But the rest seems to work, I’ll have an explore.

Short version: it looks like given the location of the variations seen in the DeocdeME data it’s more likely that in people with ME/CFS the CA10 protein is being produced in the wrong amounts in certain tissues

Inspired by some AlphaGenome stuff I’ve been learning more about and am interested in looking at promoters and enhancers for some of these candidate genes. Source If you look at the genecard for CA10 in the genomics section you can see GeneHancer info on these. There’s lots of interesting...

Excited to see this, there’s a few labs taking similar approaches but I’m hopeful for what this team can achieve in time. Some good background podcasts on Isomorphic, AlphaFold and Isomorphic too https://overcast.fm/+AAToPspnio8 https://overcast.fm/+AAToPvBVGSk

That makes sense to me. They have patients who want support and their job is refer people to the correct pathway so that’s what they do. I’m not sure there’s a widespread ideological belief in general practice beyond that.

I was reading the wikipedia page on the neurochemistry of the nucleus accumbens and I know glutamate receptors are all over the place but it’s interesting given this is another area flagged in one of the other clusters in my analysis of the PrecisionLife data (for patterns of high expression in...

My feeling since digging into it is there’s signal in that PrecisionLife data. I can see potential stories, we just need someone able to tell what’s fairytales and what can be backed up.

Agreed. I think it would be difficult to tell if a symptom is a ‘brain’ symptom given how little we understand about what is ‘brain’ and ‘not brain’ (my view is it’s very blurry) and given all the other points I mentioned that may confuse how people report what/how they improve. But that’s just...

I figured people would improve slightly differently just as they’re ill slightly differently. That each of us has slightly different symptoms we see as dominant is reflective of that along with what @Kitty says about noticing different things (I sometimes take painkillers for a headache and...

On step counts, the assumption that step counters are impartial and accurate is IMHO a very questionable one. I’ve found them unreliable, admittedly I’m severe and haven’t tried all the devices, but that’s the point, they have different hardware and algorithms and suitability. One I had counted...