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Looks very interesting. And potentially relevant if used for annotation and helping finding the impact (on say transcription) of SNPs but possibly just more widely understanding the genome. Between this and AlphaGenome it looks like there’s some really interesting and potentially important work...

Something I only recently got my head around is what CD38 is. Posting in case it helps others and to check my understanding if anyone wants to correct me! I assumed a straight receptor. Then found it had dual (or multiple) roles but I was still thinking about it wrong. Now I may still be wrong...

Sorry I haven’t been able to keep up with this thread despite the importance of it more widely but very much to me. I did just remember we had this thread, maybe a bit more wide but could be something useful https://www.s4me.info/threads/our-own-delivery-plan.45305/ My GP seems very happy to...

Sharon Hodgson MP has been appointed as the Minister for Public Health and Prevention in the Department of Health and Social Care. I don’t know much about her but #ThereForME posted saying she’s been a long-standing supporter of people with ME/CFS.

I agree @Eleanor that there is a lot of misinterpretation of what’s going on by some doctors. My experiences have certainly been miles away from the clinical depression I experienced some years prior to ME/CFS. Something I’ve been interested in recently is he link between interferon and...

Great to have you here @desmolysium and thanks for joining! I hope you’re able to stick around and get involved. There’s some really interesting ideas coming out of some of the genetics studies as well as research by a few other groups and I’m sure people be happy to point you in the right...

Absolutely. Ideas are great. Especially new ones. We’re so used to seeing the same assumptions and ideas being repeated that it’s probably not surprising there can be a bit of a ‘here we go again’ reading some things. I know I find myself doing it and try to remember those new to the topic...

A biohacking MD https://desmolysium.com/ There’s a lot there, can’t say I’ve read it in great detail but it seems to have a certain perspective The Long Covid piece that apparently led to the ME/CFS piece https://desmolysium.com/covid/

That’s part of the problem, there isn’t one definition so it means different things to different people. So it can range from perhaps just making sure someone is getting enough good food and rest to healthy or ethical living, managing physical and mental health, the idea of looking at the...

Wasn’t sure where to put this, but think it’s worth mentioning Source: https://labourlist.org/2026/03/ashley-dalton-resigns-health-minister/

Before we had treatments for now treatable disease all we had was spontaneous recovery. Look at the history of TB and the sanatorium. Those who could afford it went to nice clinics in the countryside and were looked after, some recovered, others didn’t. Various ‘treatments’ were tried. Those...

I started to writing this elsewhere but decided it better sat in its own thread. I talk a lot about the science but wanted to touch on something perhaps more fitting with the spirituality thread although also more wide ranging. One of the reasons the holistic thing gets to me is it is both...

This. The incentives are all wrong. Added to what @Hutan says if even a well meaning Doctors wants to help, they find they cannot within the NHS, so they setup private practice and there the incentive is even more to say you can do things you cannot. Who would pay through the nose for someone...

No they are not. Like its predecessor the paper appears to overstate its value and use when all thot has been done is massage some numbers. There is no evidence this tells us anything about the real world or gives us biological insight given we have little to measure against. I’m not convinced...

So you can hit a measurable outcome of papers published for funds given?

The picture for exactly what the effect of this reduced calcium availability has is less clear. There’s an effect, but does it support or inhibit cGAS-STING, does this increase or decrease IFN production, all seems to vary. But the paper in this thread and those below show levels are important...

A bit more of an explanation and some sources, first on CD38 and calcium Daratumumab in multiple myeloma So CD38 is a protein on the surface of some cells and can act like a receptor or be used as an enzyme in producing cyclic ADP-ribose (cADPR), which itself mobilises calcium from...

Really useful to have the BED detail file and instructions anyway so thank you. Learning how to do custom tracks is on my todo list after you pointed out some of the Genome Browser features elsewhere recently, but having an example will help a lot!

Nice! Thanks @jnmaciuch Edit: I think the link you shared has your session ID or something at the end of the URL, as it already has your custom track applied!

Just commenting to potentially tie this together with comments in this theead on daratumumab Also see the NCBI page on CD38 which says And lists this from gene ontology involved_in positive regulation of cytosolic calcium ion concentration So, presumably if Dartumumab acts on CD38 it...