Search results

I"m excited that Hwang has his eye on ME/CFS all the time, even in papers on pre-existing research streams that needn't mention it. I feel we have him on our team now! I remember that in his big paper he found weird issues in PERK and eif2-alpha., which are activated by endoplasmic reticulum...

I used to be a patient there and I've done the test. Admittedly it was over 10 years ago (possibly I"m even in the research cohort being discussed!). I thought the nurse recorded a subjective score but it was given by me, I vaguely remember them asking me to rate my difficulty holding it...

This looks like really clean basic science, I like it, perhaps it causes an aha moment for another research group. I've never heard of ADAR before but certainly the antennae go up when we see adenosine and inosine mentioned.

The last couple of minutes were particularly interesting in my view. Daniel gave his best guess for a big picture explanation of ME/CFS, and he basically says that evidence suggests: immune cells (probably b-cells and cells derived from them) are over-reacting, perhaps because of a) a signal...

Doctor told me I had Raynaud's. It had come on suddenly. My main symptoms was that when my nose or fingers got cold they began to hurt - a lot. Curiously it went away again later, then came back later still. I later learned that too much vitamin b6 can cause peripheral neuropathy...

Quote from an mecfs person who had the neck-fusion surgery, taken from the open internet: "do not mess with your neck. I made that mistake and will pay for it forever - in spades." I'm actually open-minded about whether it might be causal in some cases and I"m way more forgiving of people...

This is an apt comment; I think it points to how trends in understanding medicine determine what gets cured in each era. Another of my favourite examples is scurvy, which was famously "cured" centuries ago, but then scurvy came roaring back among polar explorers only 100 years ago and the Royal...

The short answer is epidemiology. In the early 1940s in the Netherlands they had no wheat. The children's doctor who was usually in charge of coeliac cases found himself putting his feet up for a few years. While twiddling his thumbs, he developed a hypothesis, and later tested it. In my...

Yes! I look forward to being able to say, aha, this is why the rituximab study showed this, or why this scientists went down this rabbit hole, or why these people from this culture /with these genetics didn't seem to suffer so badly, etc etc. I'm also wondering if by imagining ourselves in that...

I've done six things at the same time to help get rid of my histamine intolerance and they seem to have worked. I will now test them one at a time to see what was the biggest and most important part. 1. Cut out shark liver oil which I was taking; fish are famously a source of histmaines and the...

Agree with that in general. What do you think about the inverse idea - that being in rolling PEM can lower your baseline ?

Here's another familiar-seeming snippet on the history of coeliac: before they know the cause, some doctors propose it has a "nervous" cause.

Among the implications of the banana diet is a rebuttal to the popular saying: "if that worked we'd know." This diet did work, at least as long as the coeliacs stuck to it, but it was not considered legitimate. I suspect we view evidence through a theory lens and tend to dimsiss evidence that...

One made-up example about pacing: Say our blood vessels are providing inappropriate blood flow to the brain and scientists discover that the brain is exceptionally sensitive when blood flow error signals are on both the high and low side, and calls in a centrally-mediated immune reaction...

Before coeliac disease was understood, there was the banana diet. It was something of a joke at the time, but coeliac disease was fatal for children and so people were desperate. We now know that it would work as a coeliac treatment and why. Today it seems far less crazy. But at the time the...

This matches my experience too. Even though my strength is okay (can lift my 20kg child easily), and my fitness is okay (could do a ten minute bike ride right now). I can't do a full day of activity, or even a half day, or even an hour on my feet really, without big PEM. I need to intersperse...

I agree with this, we will not be afforded the luxury of being immune to deconditioning. It's not the number one cause of our problems, not by a long shot. And even if it is there, doesn't mean doing exercise is worth it. The short-run symptom cost of exercising is for most people greater than...

If you're in R this wll print an r^2 value right on top of your chart install.packages(ggpmisc) library(ggpmisc) p+stat_poly_eq() https://www.rdocumentation.org/packages/ggpmisc/versions/0.6.0/topics/stat_poly_eq

A good spreadhseet for the human eye would have studies in rows and molecules in columns. But I think this data would be too big for the eye. You'd need what they call long data, or tidy data, where each row contains only one patient-to-control ratio, and many markers by which you can filter...

Peroxidasin is intersting to me, it might help explain POTS Mammalian Peroxidasin (PXDN): From Physiology to Pathology PXDN expresses in the endothelial cells and secretes into blood. PXDN exhibits with much higher concentration in plasma than MPO [20]. Therefore, it is reasonable to speculate...