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Sometimes a literature review like this can be the first step before starting a project. Perhaps this final line of the abstract is an alley-oop for the next phase of work she will be doing? >However, further research is required to determine their specificity to ME/CFS and adoptability for...

I couldn't understand this at first blush but it seems like the proteasome is a organelle-ish type thing in the cell that breaks down proteins; upregulation could be a sign of ER stress, is that the idea Daniel? The Roles of the Ubiquitin–Proteasome System in the Endoplasmic Reticulum Stress...

i appreciate Baraniuk writing this paper. If I recall correctly he got the big bucks from the NIH and he's doing the right thing by us here, wringing every last drop of possible information out of his samples. I particularly like the way he is using multiple different statistical techniques and...

The other finding screaming out for replication is Hwang's WASF3 finding but could you even see it in blood? He used muscle biopsy samples. What you can measure in serum apparently are the Endoplasmic reticulum stress markers GRP78, PERK and CHOP which were also part of his finding (noting that...

I'd love to see the theory that peroxisomes are dysfunctional (Che, Lipkin Bridges 2022) investigated by checking the plasmalogen content of erythrocyte membranes. We have developed a test method for the simultaneous quantitation of C16:0, C18:0, and C018:1 plasmalogen (PG) species and their...

7 month update, I can't rule out the possibility that plasmalogen supplements have helped me, I have felt a bit healthier / better over the last six months, been doing more exercise. Quite a few papers have come out on plasmalogens too, including these two that involve dietary supplementation...

I remember a long thread about purinergic signalling; what I learned from that is that eATP 1. breaks down fast 2. operates on the cell it came out of (autocrine signalling) and a few nearby cells (paracrine signalling). 3. exists in a thin, tiny "halo" around the cell So you can't expect to...

I think this is a good point and even among the various covid variants we might be able to tease out why early variants seemed to cause more long covid than more recent variants. Are enteroviruses our major lead on the most likely type of virus to leave lingering symptoms?

Hanson has been vocal about the possibility that specific viruses create specific responses and Long Covid migth be distinct from ME/CFS. I recall watching a speech where she was quite cross on this topic. I think she's probably wrong but I respect the approach. To my eye the more important...

This is great research for Alzheimers. Finally lifting their eyes from the amyloid clumps to think about other brain processes. Could be just what they need to get this disease out of what may be the biggest dead-end in current research. There is potentially useful spin-off for us if the...

Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy Wesley Brandao 1 , Nimansha Jain 2 3 4 , Zhuoran Yin 1 5 , Kilian L Kleemann 1 6 , Madison Carpenter 1 , Xin Bao 2 3 4 , Javier R Serrano 2 3 4 , Eric Tycksen 7 , Ana...

You love to see drugs getting tested, even when the cohort definition is a bit iffy. This one seems to have come out of left field. I looked through the clinical trial data and it wasn't obvious who the researcher behind this is. The only name I found was this guy who is the boss of virology at...

POssible linkages here from adrenergic theories of me/cfs / cerebral blood flow theories of mecfs to why sleep is non-restorative in me/cfs, but you'd need a lot more work to establish them as any sort of fact. Still, could be worth someone applying for funding to look at cerebral blood flow...

I'm happy to answer this but I don't want anyone to think I'm recommending this for them. I've had mild me/cfs for 22 years now and I know my body and this is what works for me: Walking has usually been the worst idea for me. I can walk a bit - I'm mild. But there's a hard limit and I can't...

I find this very interesting because of an effect I've noticed when i'm on a diet: high risk but slow-building benefit. if i reduce my food intake, I risk acute energy shortage if I push too hard, and that can cause PEM. However, if I succesfully avoid that acute problem, the calorie...

I recommend against exercise. But I am also open to this being a situation where the poison is also part of the treatment. Consider electrolytes in cholera. Until they figured out the perfect osmotic ratio for electrolytes in oral rehydration solution, giving electrolytes killed the patient...

This feels like a gigantic pivot from Scheibenbogen away from autoantibodies. Maybe overdue!? But the hypothesis is far too strong given the state of the data. Based on our current knowledge on the known causes of muscle damage related to exercise and malperfusion, diminished function of ion...

That's unbalanced enough that despite the label I'm wondering if they've actually remembered to log transform on the x-axis. (A protein can rise by more than 100% but not fall by more than 100%)?!

It may have been Naviaux 2017, Sphingolipid was among the strongest findings there : This idea also brings Naviaux's thinking to mind, with his theories about failure to wrap up the cell danger response. Seems he has coined the term "salugenesis" to describe returning to health. Salugenesis...

A parallel expression is "climate skeptic", and they're usually skeptical of there being a problem at all. So my vote is for a name change. I suggest ME/CFS Science Reviews.