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The CDC's CFS symptom inventory likely isn't very reliable, diagnostic criteria require a clinical examination to assess symptoms and exclude alternative causes for the symptoms, not just a quesitonnaire. So rather than a large number of people with CFS being undiagnosed, it might just be that...

Perhaps not much as there doesn't seem any immune deficiency or notable susceptibility to cancer in ME/CFS. A risk factor for ME/CFS also doesn't seem likely. So it's presumably some innocuous downstream side-effect of the hidden immune process that is relevant to ME/CFS pathology? When I look...

Looks like low NK cell cytotoxicity has also been reported in systemic sclerosis where increased TGF-beta is a hallmark feature. Abnormal Natural Killer Cell Function in Systemic Sclerosis: Altered Cytokine Production and Defective Killing Activity - ScienceDirect There are lots of things that...

Could lower NK cell cytotoxicity in ME/CFS be due to increased TGF-beta (the cytokine found to be most consistently increased in ME/CFS). Think these are the two immune findings with most consistency across studies (although there is still quite some inconsistency). There are several studies...

Very lage sample size (n = 2068) but hard to extract any new or useful info from the study.

They give an indication of the sampling variance of your estimate if you repeated the experiment multiple times. Suppose you test 20 ME/CFS patients and find that their mean fatigue score is 10 points. But the 20 ME/CFS patients you've chosen might not be representative of the entire ME/CFS...

The biobanks will likely record the most important stratifiers and harmonize their methods. Not sure if it will take everything you mention into account but it will likely be better and more robust than most of the studies we had thus far. And with big enough sample sizes abnormaliities limited...

The consortium might not be able to do everything on our wish list but it will enable large omics studies which will likely be useful for the entire field. So don't quite get why that would be worrying. There might be new leads if we test ME/CFS with large enough sample sizes. These Horizon...

Why worryingly? Bigger samples sizes and more omics data that is not hypothesis-driven seem quite welcome.

It's not public yet, seems like MERUK announced it a bit early but suspect that more info will be available soon. Think it's great news.

Think the main conclusion was (or should be) that there's a lack of overlap between what these studies found. Even with a lenient false discovery rate (FDR) of 10%, there were only 2 study that pointed to similar genes. In this case it was MT-RNR1 and MT-RNR2 which came up in the Raijmakers (N=...

Thanks very much for your detailed analysis @Hutan . I know you previously had a closer look at the HPA-axis findings in ME/CFS. Did you notice any consistency regarding a blunted ACTH response? I came across several older studies that reported this by using different stressors to test the ACTH...

Wrote a summary of this protocol on social media: 1) The protocol for the MELLOW study (ME/CFS + Long COVID Longitudinal Omics and Women’s Health) has been published. It will look in-depth at the influence of hormones and the menstrual cycle in both diseases using home sampling. 2) The...

Bumped into this old study that might be relevant to the CRH-autopsy findings. Abnormalities in response to vasopressin infusion in chronic fatigue syndrome M Altemus 1, J K Dale, D Michelson, M A Demitrack, P W Gold, S E Straus Abstract Several neuroendocrine studies have suggested...

Wasn't thinking much to be honest. Just bumped into this older PET study when looking for something else. Didn't know about it before. Interested in hearing what others make of it.

An old PET scan on 10 CFS patients that found reduced binding to serotonin receptors in the hippocampus. Was wondering if it might be relevant.

Abstract Background: Research from neuroendocrine challenge and other indirect studies has suggested increased central 5-HT function in chronic fatigue syndrome (CFS) and increased 5-HT1A receptor sensitivity. We assessed brain 5-HT1A receptor binding potential directly using the specific...

Thanks, I certainly missed it.

Do they explain this in this paper? Could you or someone else quote the passage, can't seem to find it.

Supplementary file 4 is the TIMES final version. Attaching it here so that people can more easily acces it.