Search results

Yes and out of 58 questions only 1 asks about PEM. In comparison there are 9 questions about cognitive problems, 7 about pain, 6 about sleep, etc. So this does not seem in proportion. It also only takes 1 symptom to be completely disabled. So counting how many symptoms a person has a based on...

Thanks. Looks like the Pariante and Ng projects weren't really about ME/CFS, the McArdle project only published an abstract, and the Nutt project only a trial registration?

Thanks. I'm aware of Newton's research and the Pariante study but the others do not ring a bell. EDIT: did any decent studies come out of the grants to Dr. Ng and Prof McArdle?

Old BMJ article about MRC funding for ME/FCS with comments from Stephen Holgate and John Williams. Researchers get £1.6m to look at scientific basis of chronic fatigue syndrome | The BMJ From a historical perspective: was wondering which teams got funded and which papers came out of this? Does...

I don't really get what the point is of articles like this in a newspaper. It doesn't get much info across about Long Covid, ME/CFS or its treatment. It's mainly just about this person being able to scuba dive again.

The Dr. Sanders who promotes exercise is Lisa Sanders, medical director of Yale’s long Covid multidisciplinary care center.

Quote from the article:

So apparently we now have 4 teams doing a trial of low-dose Naltrexone in ME/CFS: - Marshall-Gradisnik at Griffith University, Australia - Yarred Younger at University of Alabama, USA - David Systrom at Brigham and Women's Hospital, USA - Luis Nacul at the University of British Columbia, Canada...

Just speculating here but perhaps it has to be a certain kind of infection, like a severe viral infection, that ME/CFS patients are less likely to get because of social isolation. But most cytokines already seem normal or low in ME/CFS while the symptoms signal runs full strength. So perhaps...

Bit of a long shot but was speculating that if the neural pathway that induces symptoms is constantly on, even without the cytokines that normally trigger it, then perhaps artificially raising the 'feeling bad' cytokines such as interferons might help to reset or recalibrate? If ME/CFS...

Sounds interesting. Only a bit worried that the text doesn't mention controls that don't have ME/CFS or Long Covid. If I understand this NULISA technique correctly it requires two matching antibodies to bind to the target protein. One uses a magnetic bead, the other a DNA tag. The antibodies...

There are newer models like FLAMES that likely give slightly better predictions to which DecodeME genes are involved to ME/CFS. I suspect this is something that could be solved with AI and machine learning in the near future, similar to what AlphaFold did for protein folding.

No problem. Just wanted to clarify because without context it could perhaps be misunderstood as if I started with the neural hypothesis to look for genes that fit the hypothesis, etc. One issue is that there are a lot of other genes nearby the DecodeME signal, making it less certain which genes...

To clarify: I didn't highlight NEGR1 much in my blog article because the gene was quite far from the DecodeME hit. I didn't assume ME/CFS is a nervous system disease and tried looking at potential genes from that angle. Instead, I focused on the protein-coding genes closest to DecodeME signals...

The supplementary table gives the scores for each of the items

Don't think this was one has been increased much in ME/CFS? IL-10 was in some but not many. TGF-beta has been the most consistent one but even there many inconsistent results. For comparison to ME/CFS, just made this brief summary of the cytokine literature on social media 1) Been looking at...

Thanks

This is a literature review. Was wondering if there's some consistency in cytokine responses in Long Covid. There were some big studies that pointed to inflammatory cytokines such as IL-6 being increased such as this one: https://www.nature.com/articles/s41590-025-02353-x Does anyone have...

Abstract Post-acute sequelae of Covid-19 (PASC) refer to persistent symptoms lasting weeks to months after acute SARS-CoV-2 infection. However, identifying biological mechanisms, potential therapeutic targets, and modifiable environmental risk factors remains necessary. Here, we analyzed...

An article about this: https://fortune.com/article/demis-hassabis-deepmind-artificial-intelligence-google-alphabet-drug-discovery-isomorphic/