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Another paper on this for those interested: Link: https://pubmed.ncbi.nlm.nih.gov/11705431/

An addditional study by these authors, this time using GP records in 11 practices in Devon, UK. They found that CFS patients had more GP consultations for various complaints in the 15 years before their diagnosis than controls with MS. This could point that CFS patients were never truly...

Excellent blog, clearly written, thanks! Perhaps not very relevant but Jason also looked at seasonal onset in his Chicago cohort and found significantly more cases where onset was in January compared to other months. Seems likely to be due to chance in my opinion (it had a low sample size of...

Found this old 2001 paper on Chiari malformation surgery in fibromyalgia and CFS Can fibromyalgia and chronic fatigue syndrome be cured by surgery?

Older 2-day CPET studies such as the one by Davenport also used the Fukuda criteria so that alone likely wouldn't explain the results. Severe ME/CFS patients can't do these test so highly likely that these were mild-moderate patients just like in previous 2-day CPET studies. The idea was that...

Hard to take anything useful from this paper... Seems like all of Jason's studies are now based on that distinction between moderate ME/CFS and severe ME/CFS. But the latter is not actually severe ME/CFS, just patients that meet more than one case definition for ME/CFS. They then conclude...

Think it's mentioned in the text, not in a table.

Been a while since I read this paper but think this is found in the test by group interaction of their ANOVA modelling.

Looks like they failed to replicate the 2-day CPET results, although look forward to seeing the actual data. The most replicated finding was workload at the ventilatory threshold which they don't report in this abstract.

An older study that I hadn't seen discussed much. It uses insurance data of the company Medical Sickness Group. Found 133 CFS cases and compared them to MS patients and non-claimant controls. They could look at a median of 10 years before the claim of CFS. Results showed that ME/CFS patients in...

Link: https://pubmed.ncbi.nlm.nih.gov/9507441/

Don't remember, this was back in 2021. Probably no reason, just a rejection.

Trial data suggest that Coenzyme Q10 plus NADH supplementation is not an effective treatment for patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) Castro-Marrero and colleagues conducted a randomized controlled trial on 207 patients with myalgic encephalomyelitis/chronic...

Wrote a critical letter to the journal to highlight the problems but it was rejected.

The German ME/CFS Research Foundation also has registry where they list ME/CFS projects since 2019. It initially focused on Germany only but has expanded to a couple of other countries such as The Netherlands. Research projects – ME/CFS Research Registry

I doubt that AI could do this, what I have seen is mostly people using existing PubMed tags or things mentioned in the abstract. With a team it should be doable to screen all ME/CFS papers on PubMed: there are approximately 7700 at the moment. Many are short commentaries or letters. I (and many...

To give an example, it allows you to filter on symptoms such as post-exertional malaise. It would be quite useful to quickly get an overview of studies that focus on PEM as its main topic. Unfortunately, this website probably uses mentions of 'post-exertional malaise' in the abstract. This...

The website looks impressive but it seems like it's mostly AI summaries and AI evidence ratings of ME/CFS studies. That can give impressive looking overviews and graphs but if nobody is doing the hard work of checking and evaluating results, then its quite the opposite of useful.

Looks like there was no control group. I also thought they already published similar data in this paper: Cerebrospinal fluid immune phenotyping reveals distinct immunotypes of myalgic encephalomyelitis/chronic fatigue syndrome - PubMed

Looks like fluvoxamine is a serotonin reuptake Inhibitor but that it's a bit different than other antidepressants because of its high affinity for sigma-1 receptors. Would be interesting to compare fluvoxamine to another SSRI and a placebo to see if it beats both.