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They did a lot of comparing their findings to a previous migraine GWAS: New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis (2021, Communications Biology) I took a look at that paper, and interestingly, in the MAGMA analysis in that study...

Some other studies to potentially look at. I just quickly grabbed quotes about bimodal distributions, and haven't read the papers: Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China (2023, J Headache...

Ages for peaks from ME/CFS papers, to compare to this study: StudyConditionFirst peak (SD)Second peak (SD) Bakken 2024ME/CFS10-1930-39 McGrath 2026ME/CFS16 (4.3)36.6 (10.5) Victor 2010Migraine (Women)25 (8.6)50 (15.8) Victor 2010Migraine (Men)18.7 (7.4)47.6 (16.8) The peaks seem to...

Speculating that hormonal changes might cause second peak in men. Previous studies had not seen this bimodal effect. They speculate that it is because other studies used 5 year age groups instead of 1 year, and because they used populations that didn't span as large of a range in ages as this...

This study was found by Murph when discussing whether migraine and ME/CFS may be related: I posted so we could examine whether the bimodal distribution looks like it might be showing the same thing as in two ME/CFS papers: Two age peaks in the incidence of chronic fatigue syndrome/myalgic...

Migraine prevalence by age and sex in the United States: A life-span study Abstract The present study assessed age- and sex-specific patterns of migraine prevalence in a US population of 40,892 men, women, and children who participated in the 2003 National Health Interview Survey. Gaussian...

Is it possible that individuals with T2D in the ME/CFS group are driving large differences in lipids from healthy controls, with T2D having little to do with ME/CFS specifically? I mean there will be individuals with ME/CFS and T2D, just as there will be individuals with hypertension and T2D, or...

Right, you previously mentioned that: So I guess for me, the concern with regard to comparing to other conditions could be summed up as such: It seems to me that if there were individuals with any of hundreds of comorbidities, such as T2D, in the ME/CFS group, but any such individuals were...

The scientific arguments presented here by Hutan seem clear to me as well. The sensitivity analysis seems to support that these findings are being mostly driven by comorbidities. While there were still some significant findings, there were also hundreds of other comorbidities in the sensitivity...

I previously saw that the MAGMA results in an anxiety GWAS showed the same top four enriched tissues as DecodeME: This migraine study also matches for those top four tissues:

A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder Abstract Migraine is a neurovascular disorder that poses a high burden to Veterans, who face a greater risk than sex-matched...

Note that we also have this migraine-related thread: Migraines and ME/CFS - Thread for sharing experiences

Small correction that one group, hypertension, had a higher median BMI.

Interesting! Maybe another similarity, from Wikipedia: A paper discussing whether ME/CFS might improve during pregnancy: Chronic fatigue syndrome: implications for women and their health care providers during the childbearing years (Journal of Midwifery & Women's Health, 2008) There's a...

Not just one statistic. One p-value for every one of the millions of genetic locations that were tested in the GWAS, based on how often there was a variant at that location in ME/CFS versus the controls. The summary stats are often publicly available, including for DecodeME. There are a few...

No, it is comparing GWAS summary stats from two different conditions. For example, the DecodeME summary stats give us an idea of how much each variant is associated with ME/CFS on a population level. They obtained summary stats for migraine and several other conditions as well, and compared each...

Genetic correlations are basically showing how similar the genetic influences are for two traits. If completely different variants were associated with ME/CFS compared to migraine, then the genetic correlation would be 0. If the exact same variants were associated in the same direction with...

Comparing ME/CFS following mononucleosis with Long COVID Jason, Leonard A; Furst, Jacob; Katz, Ben Z Objectives Long COVID following SARS-CoV-2 and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) following infectious mononucleosis (IM) are examples of post-infectious chronic...

How Revolving Door Officials Shaped, Cross Validated and Closed the Official Khamisiyah Chemical Exposure Determination Despite the Evidence, 1995-2002 Ford, Jeffrey S Abstract The official Khamisiyah chemical exposure determination was presented as a scientific conclusion reached through...

I guess I don't see why not. Maybe I'm not understanding something about the methods. There will probably be a portion of migraine sufferers, or asthma sufferers, who have type 2 diabetes or any of dozens of other conditions, just due to some people having more than one condition due to random...