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Genetic correlation A recent preprint found a genetic correlation of rg=0.45 between ME/CFS (DecodeME) and a USA migraine cohort. This figure is similar to the genetic correlation value I found when testing correlation of DecodeME with other migraine cohorts (UK BioBank and FinnGen). Insights...

I thought it'd be good to have a public thread for general discussion about how ME/CFS and migraines may be related. We have a members only thread for sharing experiences as well. Mainly, I want to link relevant discussions happening on various threads, so they don't eventually get buried.

The following study is actually about incidence rate, and brings the second peak in line with the figures for the second ME/CFS incidence peak. The first peak is a bit later than in ME/CFS, though. Another study for incidence rate peaks. It's a small (n=75) study, only on those with Von...

Oh, actually, this is comparing incidence peaks in ME/CFS to prevalence peaks in migraine. I think prevalence would be expected to peak later, though I'm not sure how much later. So maybe the ages of the migraine peaks are closer to ME/CFS than it seems from this.

The first MAGMA plot above is for 54 specific tissues. For the more general tissue grouping, there were two significant tissues showing enrichment of GWAS genes, both in the full cohort, and in the men-only cohort: brain and uterus. Here is the plot for men: This is interesting, because males...

They did a lot of comparing their findings to a previous migraine GWAS: New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis (2021, Communications Biology) I took a look at that paper, and interestingly, in the MAGMA analysis in that study...

Some other studies to potentially look at. I just quickly grabbed quotes about bimodal distributions, and haven't read the papers: Trends in migraine incidence among women of childbearing age from 1990 to 2019 and the prediction for 2030: an analysis of national data in China (2023, J Headache...

Ages for peaks from ME/CFS papers, to compare to this study: StudyConditionFirst peak (SD)Second peak (SD) Bakken 2024ME/CFS10-1930-39 McGrath 2026ME/CFS16 (4.3)36.6 (10.5) Victor 2010Migraine (Women)25 (8.6)50 (15.8) Victor 2010Migraine (Men)18.7 (7.4)47.6 (16.8) The peaks seem to...

Speculating that hormonal changes might cause second peak in men. Previous studies had not seen this bimodal effect. They speculate that it is because other studies used 5 year age groups instead of 1 year, and because they used populations that didn't span as large of a range in ages as this...

This study was found by Murph when discussing whether migraine and ME/CFS may be related: I posted so we could examine whether the bimodal distribution looks like it might be showing the same thing as in two ME/CFS papers: Two age peaks in the incidence of chronic fatigue syndrome/myalgic...

Migraine prevalence by age and sex in the United States: A life-span study Abstract The present study assessed age- and sex-specific patterns of migraine prevalence in a US population of 40,892 men, women, and children who participated in the 2003 National Health Interview Survey. Gaussian...

Is it possible that individuals with T2D in the ME/CFS group are driving large differences in lipids from healthy controls, with T2D having little to do with ME/CFS specifically? I mean there will be individuals with ME/CFS and T2D, just as there will be individuals with hypertension and T2D, or...

Right, you previously mentioned that: So I guess for me, the concern with regard to comparing to other conditions could be summed up as such: It seems to me that if there were individuals with any of hundreds of comorbidities, such as T2D, in the ME/CFS group, but any such individuals were...

The scientific arguments presented here by Hutan seem clear to me as well. The sensitivity analysis seems to support that these findings are being mostly driven by comorbidities. While there were still some significant findings, there were also hundreds of other comorbidities in the sensitivity...

I previously saw that the MAGMA results in an anxiety GWAS showed the same top four enriched tissues as DecodeME: This migraine study also matches for those top four tissues:

A multi-ancestry meta genome-wide association study of migraine among veterans: associations with traumatic brain injury, depression, and post-traumatic stress disorder Abstract Migraine is a neurovascular disorder that poses a high burden to Veterans, who face a greater risk than sex-matched...

Note that we also have this migraine-related thread: Migraines and ME/CFS - Thread for sharing experiences

Small correction that one group, hypertension, had a higher median BMI.

Interesting! Maybe another similarity, from Wikipedia: A paper discussing whether ME/CFS might improve during pregnancy: Chronic fatigue syndrome: implications for women and their health care providers during the childbearing years (Journal of Midwifery & Women's Health, 2008) There's a...

Not just one statistic. One p-value for every one of the millions of genetic locations that were tested in the GWAS, based on how often there was a variant at that location in ME/CFS versus the controls. The summary stats are often publicly available, including for DecodeME. There are a few...