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  1. Jonathan Edwards

    Covid-19 vaccines and vaccinations

    No, quite the opposite. There is a reasonable chance that vaccine to one coronavirus will provide some protection against the next. There is no known situation where it works the other way as far as I know. But I'm only a professor in the department of infection and immunity at UCL.
  2. Jonathan Edwards

    Caught up in Care: Crafting Moral Subjects of Chronic Fatigue, Risor and Lillevoll, 2021

    There is something very distasteful about something like this published in 'Medical Anthropology - almost as if it is a visit to the zoo. It stinks of busybody voyeurism. A study like this is only ethical if it is part of a valid piece of practical clinical research suitable for a medical...
  3. Jonathan Edwards

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    It looks as if Strain genuinely wanted to distinguish Long Covid from 'pulmonary or cardiac rehab' rather than ME/CFS. But I think the problem goes much deeper. The whole idea that you need a structured exercise programme 'in order to get better' looks to me phoney busy-bodying of the sort I met...
  4. Jonathan Edwards

    News about Long Covid including its relationship to ME/CFS 2020 to 2021

    David Strain @DocStrain · 19 Oct 2020 So to set the record straight. I said Around 2/3rds make a good recovery and live a normal life. To a large number of people this is a hugely debilitating life-long condition. Please accept my apologies for the way it came over. We do listen and are trying...
  5. Jonathan Edwards

    Critical of past research: cortisol studies

    Yes, it is a problem that needs to be confronted. Most fringe things slip into the trashcan - 98% I would say. There may be. Corticosteroids remained fashionable in the US much longer than in the UK. In some countries GPs use a lot of low dose corticosteroids. In the UK they are used for...
  6. Jonathan Edwards

    Critical of past research: cortisol studies

    It very much holds doctors back. When I left rheumatology I had stopped prescribing corticosteroid to almost everyone. For RA it was limited to the very old whose life expectancy was so limited that the benefit of better mobility was worthwhile. I remember when two nurses tried to lift an RA...
  7. Jonathan Edwards

    Critical of past research: cortisol studies

    That does not follow. It is true that a lot of doctors are pretty irrational or evidence-free in their decisions about certain things but across the board most follow well-founded practices for most things. A minority of physicians practice on the basis of theories outside the consensus - what I...
  8. Jonathan Edwards

    Book: When Force Meets Fate by Jamison Hill, published January 2021

    Should it be required reading for someone who thinks exercise and positive thinking are no use?
  9. Jonathan Edwards

    Critical of past research: cortisol studies

    Established professors are quite often fringe doctors, unfortunately. I think we know that corticosteroid does not produce dramatic benefit and since the adverse effects are so pervasive and long term I can see no justification for further studies.
  10. Jonathan Edwards

    Critical of past research: cortisol studies

    I think anything above 15mg is toxic long term. Cataract is quite common. There are quite a few 'specialists' like that about in Belgium and Holland in particular. I doubt there is any basis to the claim that doses can be titrated. There is a substantial folklore in endocrine support groups...
  11. Jonathan Edwards

    The biology of coronavirus COVID-19 - including research and treatments

    It is an interesting report. It looks as if megakaryocytes (platelet precursor giant cells) are getting into brain without being filtered out in lung. I am not sure that I agree with the authors that the problem is likely to be endothelial signalling changes. I suspect that megakaryocytes are...
  12. Jonathan Edwards

    The biology of coronavirus COVID-19 - including research and treatments

    Except that a simple look at the graphs for all European countries suggests that opening schools in September, as expected, led to tens or hundreds of thousands of unnecessary deaths and a brought domestic and economic life to a halt again.
  13. Jonathan Edwards

    Critical of past research: cortisol studies

    There is nothing simple about treatment with hydrocortisone, as @Perrier suggests. The basic bind is that if you give a small dose the adrenals and hypothalamus just adjust to offset it. If you give more you produce osteoporosis, diabetes, mood disturbance, acne, fragile skin and muscle...
  14. Jonathan Edwards

    The use of the labels ME, CFS, ME/CFS

    At least until the lockdown I would normally almost every day be talking to someone new and bring up the fact that I had an interest in ME/CFS. I quickly came to realise that it was no good saying I was interested in ME because most people were not sure that I was referring to myalgic...
  15. Jonathan Edwards

    My Doctor Told Me My Pain Was All in My Head. It Ended Up Saving Me. 2021 Medical examiner article

    An analysis of five clinical trials found that participants’ pain didn’t decrease on average Well that's a bit of a worry, surely? So it doesn't actually work. Or if it does it makes as many people worse as better. Yes, pain is all in the head, but we all knew that. (And I have just published...
  16. Jonathan Edwards

    NICE ME/CFS guideline - draft published for consultation - 10th November 2020

    I am not sure that one should be despondent about this. I think a huge amount has been achieved. I also think that just as habits tend to get fixed there are times when things suddenly collapse into a new mould. When I was taken to hospital with labyrinthitis recently I was very pleasantly...
  17. Jonathan Edwards

    NICE ME/CFS guideline - draft published for consultation - 10th November 2020

    With luck academic psychiatry departments will lose interest in ME research and services will move more towards medical clinics but it will take time. I really don't know how different things will be in practice for a while. GPs were always supposed to be empathetic and risk assess etc. ...
  18. Jonathan Edwards

    NICE ME/CFS guideline - draft published for consultation - 10th November 2020

    Nobody gets notified in such a way that they are likely to read it. There are far too many guidelines to read regularly. Over a period of time GPs and consultants get exposed to educational material that is supposed to update them but it is fairly optional. Some issues are contentious and...
  19. Jonathan Edwards

    What doctors with a specialist interest in ME/CFS do online consultations?

    I am happy to give an expert armchair professorial opinion in the abstract. My opinion is that the best advice comes from free debate amongst patients on S4ME. There are no physicians who are better equipped with the scientific information than Monsieur Tack or Señor Snowlepard or Dr Wooly and...
  20. Jonathan Edwards

    UK: Petition: Specify ME/CFS on the list of neurological conditions under group 6 for UK Covid19 vaccine

    The problem as I see it is that as soon as any medically knowledgeable person sees the argument neurological condition therefore at risk therefore we should be on the list they will see it as ill-informed and not give it a second thought. If the petition said PWME are likely to be at risk...
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