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  1. Jonathan Edwards

    International: World Health Organization News (news relevant to ME/CFS, Long Covid and related conditions)

    We have been getting somewhere with Simon in charge for a while now, but don't spread it around too much. He likes to keep in the shadows!
  2. Jonathan Edwards

    The biology of coronavirus COVID-19 - including research and treatments

    There are bound to be some false negatives. All it needs if for someone to slip up somewhere. I have no idea what percentage though.
  3. Jonathan Edwards

    Physical activity in a pandemic: A new treatment target for psychological therapy: Diamond and Waite June 2020

    Psychological therapists can respond creatively That would seem to sum things up. Isn't that what they always do;) At least that seems to be what they do in Oxford. If anyone needed evidence that this is a department of pseudoscientific phoneys this will do.
  4. Jonathan Edwards

    Coronavirus - worldwide spread and control

    That is a very interesting point. So in time it should be possible to some extent to recalculate the total excess deaths due to both Covid and collapse of health care systems in a way that is not confounded by beneficial effects of lockdown. Presumably one can also make use of data from...
  5. Jonathan Edwards

    Coronavirus - worldwide spread and control

    It looks as if reopening schools in Berlin is not going well either. It is about a week before UK schools are due to re-open...
  6. Jonathan Edwards

    Coronavirus - worldwide spread and control

    Strictly speaking viruses do not mutate. Our nucleic acid copying machinery mutates them by making occasional mistakes. I would not expect that human mutation rate to alter over millions of years. The issue must be the likelihood of any mutation coming to dominate by getting copied more often...
  7. Jonathan Edwards

    Upadacitinib (rinvoq)--could it reduce fatigue in ME/CFS?

    Lots of different treatments that reduce cytokine-driven inflammation in RA reduce fatigue. A Janus kinase inhibitor would work through that route so would be expected to reduce fatigue. But that means we only expect it to reduce fatigue in conditions with cytokine-driven inflammation...
  8. Jonathan Edwards

    USA - Mayo clinic

    It reminds me of: The Queen said "Oh!: And went to His Majesty: "Talking of the butter for The royal slice of bread, Many people Think that Marmalade Is nicer. Would you like to try a little Marmalade Instead?" The King said, "Bother!" And then he said, "Oh, deary me!" The King sobbed, "Oh...
  9. Jonathan Edwards

    CBT for ME that is accepted by the community.

    I don't see NICE approving ACT for ME or subsuming it under MUS any time soon. Yes the BPS people would like to continue their Morris Dancing but I think the music may have stopped in a way it has not before. I cannot predict what will come out of NICE but nobody can pretend any more that...
  10. Jonathan Edwards

    CBT for ME that is accepted by the community.

    From another angle - I actually suspect that things may improve in the not too distant future. ME-style CBT is busted. It may limp on for a while but there Interior really any way back.
  11. Jonathan Edwards

    CBT for ME that is accepted by the community.

    I actually think this is the wrong approach. Health care professionals should not be advising patients on the basis of models or guidelines but on the basis of knowledge of evidence. That has always been the way doctors work until recently and it remains the way specialists work. And why...
  12. Jonathan Edwards

    CBT for ME that is accepted by the community.

    I understand that you got value out of the advice but is this in any sense 'CBT'. I spent my life explaining to people about their arthritis, what to hope for and what to accept as the natural path of their illness and what we knew about the best way to cope in terms of activity and work and so...
  13. Jonathan Edwards

    CBT for ME that is accepted by the community.

    The 'psychological' terminology is all very confusing but I think the key difference between genuinely 'psychological' therapies and EET is that a psychological therapy is one that I based on a validated psychological theory. Even if we allow that some of the improvement in PACE was genuinely...
  14. Jonathan Edwards

    The biology of coronavirus COVID-19 - including research and treatments

    Why should effective strategy be an alternative to testing? Again no logic. We may want strategies but that does not mean shunting people off to unproven 'rehab'.
  15. Jonathan Edwards

    The biology of coronavirus COVID-19 - including research and treatments

    'Patients with COVID19 remain highly symptomatic at 12 weeks, however, clinical abnormalities requiring action are infrequent, especially in those without a supplementary oxygen requirement during their acute illness. This has significant implications for physicians assessing patients with...
  16. Jonathan Edwards

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome' 2017, Larun et al. - Recent developments, 2018-19

    Or the blog author cannot face opening up the comments box to do the approval!
  17. Jonathan Edwards

    Cognitive Behavioural Therapy for chronic fatigue and CFS: outcomes from a specialist clinic in the UK (2020) Adamson, Wessely, Chalder

    I actually think 'the Queen's English' was largely used in a different context from Amis. Following the two world wars (the first probably having the greatest impact) there was a significant shift in the social role of spoken English accent because of large numbers of working class men rising in...
  18. Jonathan Edwards

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome' 2017, Larun et al. - Recent developments, 2018-19

    The paternalistic 'I know what's best for people' attitude seeps from every seam of the system.
  19. Jonathan Edwards

    Towards the unity of pathological and exertional fatigue: A predictive coding model, 2020, Greenhouse-Tucknott et al.

    A lot of good points above. I find it hard to focus on the detailed theory because I have already concluded there are some major false premises at the start. I admire the detail of Snow Leopard's analysis. Three things have struck me. One is that, as I think Snow Leopard is pointing out, the...
  20. Jonathan Edwards

    Cochrane Review: 'Exercise therapy for chronic fatigue syndrome' 2017, Larun et al. - Recent developments, 2018-19

    Fortunately, if there is any likelihood that I might be able to say something useful someone pokes me with a stick. And I get updates from birdies from time to time.(Whistling sound heard.)
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