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I reckon this is probably the Lipkin study that had funding pulled. Some of the US institutions seem to have won a court case to reinstate funding so maybe that will go ahead eventually.

Am I correct in thinking nature scientific reports is more prestigious than nature communications? Either way it's shocking this got published anywhere.

That occured to me but I didn't know if it was even possible to increase NK cells

A lot of the physical tics assoicated with schizophrenia are actually caused by the drugs commonly prescribed to treat it.

We are living in an age of utter delusion parading around as science. This is as nonsensical as any belief in wellness/antivax circles. And it sounds like it uses the PACE trick of telling the patients how effective it is, which tells us everything we need to know. I sometimes feel like the...

I guess I meant could it be a factor - this process going awry somehow. If ifn-g and cd8 t cells are the medium by which PEM is triggered during/after activity essentially. And in terms of long term deterioration I don't know. I suppose I was thinking of this process as adding fuel to the fire...

Could this possibly explain why pwME get PEM and sometimes deteriorate after exercise? I note IFN-G increase which is of course relevant to the Edwards/Cambridge/Cliff hypothesis.

JE has said a few times that there may be repurposeable mabs that will do the trick. I think it depends entirely on what drug targets come to light. For example yesterday: As for developing a new one, here is JEs best case scenario from a while back. I think the broad point is that if pharma...

'In how many years' is the pressing question about all this no one can answer it seems . Would it also block the monoclonals? Damn I didn't realise that.

Perhaps that is true if Daratumumab works but it may well point the way to other treatments with a different mechanism that are more universally effective.

Every damn treatment that trends - mestinon, ldn, this, whatever - always seems to come with reports of worsening as well as improvement. At least we will have the data from the placebo controlled Rapamycin study and the lift ldn mestinon study in the next year or two.

It's not the first time I've seen him make it either.

I'll get my chequebook! Do you think that Jackie is likely to get that kind of funding once all of our DecodeME etc ducks have lined up over the course of the next little while?

Forgive me if I missed this in your paper, but how would we establish whether this is the case?

Younger says that a 72% response rate is unlikely because we know the ME/CFS label contains 3 different pathologies. Unless I have missed something major, or he has seen advance results I haven't, we don't know anything of the sort.

IMO this would be the perfect response/approach

This is one of the creepiest things about the whole situation imo. It is never mentioned in the glowing discourse around him unless its skirted over.

This is the thing I find most chilling about modern medical culture. If you throw a stone you hit a story of someone who's cancer or stroke or MS or whatever was missed because their doctors slickly dismissed their concerns and didn't do the necessary tests. So it isn't just us that bear the...

When your theories have been unquestionable in medical discourse for decades any dissent is going to feel like a personal attack. And the thing is no matter how politely we dissent, we are still saying that their entire career is built on a house of cards. Of course the stigmatising and...

Well, I clicked on this thread without thinking and I now want to be sick. I cannot say this strongly enough: this attitude is the reason I am severely disabled. This prejudice and the weird culture of silence and patient manipulation it creates are the reason my GP thought the way to help me...