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  1. Adrian

    Lightning Process study in Norway - Given Ethics Approval February 2022

    A wait list is not a suitable control group. It is not controlling for any reporting (placobo) biases and effects from the treatment (telling patients to ignore symptoms). All it does is compare reporting from those told to wait for treatment (who may also have an incentive to downplay any...
  2. Adrian

    Lightning Process study in Norway - Given Ethics Approval February 2022

    Another concern in any protocol is ensuring patients report harmful effects from the LP. But LP seems to be set up to discourage harms reporting so I think this should be a real issue within any trial.
  3. Adrian

    Lightning Process study in Norway - Given Ethics Approval February 2022

    Its not even replication. The protocol can't be properly peer reviewed without a detailed description of the intervention otherwise the reviewers can't tell if any controls are sufficient.
  4. Adrian

    Coronavirus - worldwide spread and control

    I was wondering how they are estimating any values for R0 given the time lags in a lot of the data quoted. Which makes me wonder about their optimism. If data quality is poor then they could be misleading themselves. Lots of the graphs do seem to show a peak has been reached but the way down...
  5. Adrian

    Coronavirus - worldwide spread and control

    Given these stories this could be an interesting analysis but the story is behind a paywall so not sure what it is saying
  6. Adrian

    The biology of coronavirus COVID-19 - including research and treatments

    Its interesting on TWiV Stanley Perlman suggested that the bad covid-19 response in the lungs may be due to a host response to the virus rather than the virus itself. That was a while ago and he didn't quote any evidence as far as I can remember. Also it seems that the viral load in children is...
  7. Adrian

    Countess of Mar retires

    It sounds like the Countess of Mar is retiring. She will clearly be a loss as she had been one of the main campaigners for ME in parliament over the last few years. Fortunately there are others supporting the cause now.
  8. Adrian

    Coronavirus - worldwide spread and control

    Could be the nudge unit nudging responsibility away from themselves.
  9. Adrian

    Coronavirus - worldwide spread and control

    From what we have seen with ME the scientists that get into positions of power are not always (often not) competent and don't challenge the prevailing view. I wonder if this will be an emerging issue as people examine what happened. I read an article about when a the currency collapsed (I think...
  10. Adrian

    Coronavirus - worldwide spread and control

    There was this article about a month ago about an abnormal number of pnemonia cases in Lombardy in late 2019 and an investigation as to whether it could have been a Covid-19 outbreak. But I've seen no more since...
  11. Adrian

    Coronavirus - worldwide spread and control

    There is now a story in the guardian suggesting that given the names have leaked there is a rush to find additional experts to plug the gaps. https://www.theguardian.com/science/2020/apr/29/government-rushes-out-request-for-experts-bolster-sage-panel The current group seems very influenza...
  12. Adrian

    Coronavirus - worldwide spread and control

    Devi Shidrar seems to have been told to shut up But given the response she seems to be carrying on. But then look at the numbers of academics in the UK who didn't speak out against PACE.
  13. Adrian

    Coronavirus - worldwide spread and control

    One of the issues with R0 is that if you measure it as an overall average for a country it could be low but it doesn't represent what is happening as there can be hot spots where transmission is still high. The danger being that if a hot spot gets out of control it could overwhelm local...
  14. Adrian

    Coronavirus - worldwide spread and control

    The Singapore one is open source. The Austrailian one isn't open source but it isn't obscured so it has been decompiled and there is an analysis that the code seems ok Code is here https://github.com/ghuntley/COVIDSafe_1.0.11.apk is a repository with the code. A document cataloging the...
  15. Adrian

    Coronavirus - worldwide spread and control

    From before mass gatherings were banned in the UK. There appears to be a bit of a hotspot in Liverpool after the Liverpool, Madrid champions league game. Also Cheltenham has a higher rate than the surrounding areas after the horse racing.
  16. Adrian

    Coronavirus - worldwide spread and control

    The decentralized collection stops data being misused later and the UK app is associated with companies that do a lot of data mining - this could lead to poor adoption of the app. There is also a real practical issue in that not using the google/apple mechanism means that the app will run far...
  17. Adrian

    Coronavirus - worldwide spread and control

    The figures depend on what is being measured. The UK figures mainly only include hospitals (I think the Scotland figures also include care homes) So the numbers are quite a lot lower than the actual death rate. This has been shown by the ONS who look at death certs but this is a retrospective...
  18. Adrian

    Coronavirus - worldwide spread and control

    There is a technical analysis of the privacy aspects of the app here https://github.com/vteague/contactTracing Others are reporting some performance/power usage issues,
  19. Adrian

    Coronavirus - worldwide spread and control

    I notice that one of the German advisors is a corona virus expert who also worked on SARS https://www.theguardian.com/world/2020/apr/26/virologist-christian-drosten-germany-coronavirus-expert-interview
  20. Adrian

    Coronavirus - worldwide spread and control

    Deaths are a lagging indicator so I would expect hospital admissions to go down prior to death rate. Testing has increased a bit which could be a factor on the reported cases (I don't think they report via symptoms but not sure). But the data does seem strange. (I also think we are poor at data...
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