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Cardiopulmonary Exercise Testing Reveals Functional Limitations and Work Disability in Severe Post-COVID-19 and ME/CFS Patients Background Patients severely affected by post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often experience long-term...

Wow, B2N2A1 was the most significant gene out of around 17,000 genes. That's pretty compelling considering the DecodeME association, as you say. These are the criteria for included variants for this gene's result: Edit: I was mistaken about the 17,000 number specifically since it includes...

Understanding Psychological Distress in CFS/ME: The Roles of Functionality Appreciation, Body Appreciation, and Illness-Related Shame Geller, Shulamit; Levy, Sigal; Avitsur, Ronit Background Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) is a debilitating chronic condition that...

German song. Video shows son's life pre- and post-ME/CFS.

Most of these are just updating the estimated study start date, increasing it by one day each time (last update). It's very odd. I wonder if an automated system has gone rogue.

Well, I was thinking cells throughout the brain could have high lactate. Not localized necessarily. Maybe all neurons or all of a certain glial cell.

Is it possible the MRS isn't very precise and gets some of the cells lining the ventricles, and that's where lactate is high? Other studies seem to show high lactate in non-ventricle regions, such as anterior cingulate cortex in Godlewska 2025 Looking at this ventricle paper, Shungu 2012, the...

I think the intracellular/extracellular point above may be wrong. Most of the MRS studies are on ventricular spaces. Doesn't the fluid in the ventricles contain very few cells? It's more or less the same fluid as CSF in a spinal tap, right? Edit: added quote

Nice detective work @ScoutB. One thing is that I think CSF represents a different compartment from what is being measured with MR spectroscopy. I don't know much about the specifics. I asked a researcher a while ago about this, who said MRS is primarily measuring intracellular lactate, while...

Since high lactate in the brain in ME/CFS seems to be a finding that keeps coming up, I'll link those papers here. Titles link to threads for papers where we have a thread. Ventricular cerebrospinal fluid lactate is increased in chronic fatigue syndrome compared with generalized anxiety...

For some reason, CA10 comes up multiple times in selection analysis of various livestock. Though I have very little understanding of what these results mean. There's the above paper on Anxi cattle, and here are three more on other animals: Edit: There's always the possibility that thousands...

This makes me wonder if in the future, it might be good to do a larger GWAS that includes both ME/CFS and IBS cases, as this might help pinpoint the common factors that make people susceptible to both conditions, with the benefit of larger sample size as well. Same thing for ME/CFS and chronic...

For SHISA6, the lead SNP for IBS in this study is actually the same as the lead SNP for ME/CFS in DecodeME, so I think there's a very good chance it's the same causal variant. Zoomed in plot for DecodeME: 42.6% of the DecodeME cohort reported IBS, so it makes sense that there are some genetic...

This shows the effect sizes for the SNPs in the individual cohorts used in the meta-analysis. I highlighted the SHISA6 lead SNP, 17-11325637-G-C / rs1546559. It's somewhat significant in UK BioBank (p=9.62e-6), not significant in FinnGen (p=0.13), and no data for this SNP in Genetic...

The researchers looked at expression of SHISA6 in a different cohort: The plot is very blurry, so it's hard to make out what that number is, but I assume it's a p-value, and I think the exponent is -10. 8 out of 9 of their GWAS candidate genes seem to show significant differential...

Maybe a connection with IBS in the following study which found an association of a SNP near SHISA6 with nausea after general anesthesia: Genome-Wide Association Study Identifies Novel Candidate Variants Associated with Postoperative Nausea and Vomiting (2023, Cancers)

Also see thread: Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic study, 2024, Huang et al

A locus overlapping SHISA6 was nearly genome-wide significant in DecodeME (thread).

Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic study Background Irritable bowel syndrome (IBS) significantly impacts individuals due to its prevalence and negative effect on quality of life. Current...

It looks like unfortunately the magic expired and the custom track is no longer at that link. Fortunately, there are ways to make it stick around permanently, described here and here. One way is to register, then you can create a named session which won't expire, and share the link. Another way...