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Lemtrada underwent review by EMA, who restricted use—final approval by EC pending. https://www.ema.europa.eu/en/medicines/human/referrals/lemtrada https://medshadow.org/ms-drug-restricted-in-europe/ https://pharmaphorum.com/news/european-regulator-restricts-use-of-sanofi-ms-drug-lemtrada/...

@Jonathan Edwards Campath-1H is less dangerous in your opinion than cyclophosphamide? Also what is the difference between Campath-1H (humanized) and Alemtuzumab? Thanks

So maybe there might be some benefit to wiping out abnormal T cells with cyclophosphamide.....

Really poor use of nine people’s time. Any funding and salary time devoted to this should have/could have been devoted to science-based science.

I would assume the difficulty is in getting MECFS brain cells, not just brain cells per se. Maybe they could induce MECFS in the cells with Cipro or the anti-cancer compounds that @RDP mentioned in other threads

https://www.medpagetoday.org/rheumatology/arthritis/83966?_ga=2.265148431.1072804894.1576686559-674435307.1570713348 Journal article here https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-019-2059-8 Looks like vitality and insomnia improved on this.

Yeah brain cells too. But they would need to get cells from MECFS patients. First cell culture of live adult human neurons shows potential of brain cell types https://www.sciencedaily.com/releases/2017/01/170117141149.htm

Anybody know if this is an established technique/method? Thanks

Ok but how does this altered T cell metabolism affect brain stem function as shown in other research?

@Badpack Is it possible that the plasmapheresis did not remove the “bad stuff” (exosomes) because they were not the right size? I assume that plasma filters are designed to remove specific size antibodies and maybe the “something in the plasma” was too small to be removed by the filters?

https://www.google.com/amp/s/www.the-scientist.com/news-opinion/northwestern-university-stem-cell-therapy-clinic-closes-abruptly--66401/amp Hmmmm

https://www.nytimes.com/2019/12/07/us/dna-bone-marrow-transplant-crime-lab.html Interesting... wonder if pwmecfs could benefit from a bone marrow transplant, especially since all of the blood will have the donor’s genotype. In other words, maybe the blood after transplant won’t have...

Voted ✅

https://www.biorxiv.org/content/biorxiv/early/2019/02/01/537431.full.pdf

Probably this... https://www.sbir.gov/sbirsearch/detail/1574495

Good point. I know i'm in the minority here, but I would recommend de-emphasizing PEM as a critical inclusion criteria. I believe a lot of folks say that PEM is the cornerstone MECFS symptom, but for the several years I was mild--say through mid-last year, I very rarely got what I think is PEM...

I used a credit card... maybe Zuck is going on a shopping spree right now. Looks like they raised about USD 30,000, which doesn’t seem like a lot...times 6 it’s 180,000....could pay for a lab machine or a couple of years of a technician.

Bump

7 million is for all the charities in the world combined, not just for OMF. That’s why one needs to donate at the exact time listed or the money goes to save the whales or something else. [N.B. Not against saving whales]

Zuck could give more than 7M.