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An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216385 In use since 1696! How about that? Maybe test in the nano-needle? (different mechanism than SS-31)

Please allow me to speculate here. Suppose Phair is correct and there are in fact two metabolic traps, #1 IDO (tryptophan) and #2 Tyrosine. Would this perhaps explain the 2 types of ME/CFS I see reported here. First, there is a group of people who have fatigue and brain fog (Brain ME/CFS)...

@Dechi ( or anyone else) How much Nimodipine do you take per day? Thanks

No Intel chips here... https://www.google.com/amp/s/spoonuniversity.com/lifestyle/10-best-tortilla-chips-ranked-by-taste/amp Did find a nice intestine recipe tho... https://wannabite.com/edible-intestines-recipe-perfect-halloween-party-recipe/

Hmmm I prefer guacamole or fresh salsa on my chips...intestines not so much...

Wonder why Fluge is speaking about the Rituximab trial. This is already published. Better that he presents the (preliminary) cyclophosphamide data.

Howard Bloom has a sleep plan and it seems to work for him (he was severe). He sleeps in two four shifts instead of one long one and attributes his improvement to this change. I should probably try this...

@Jonathan Edwards As mentioned above, these mitochondria data come from a presentation by Prof. Paul Fisher, https://scholars.latrobe.edu.au/display/prfisher, the video of which can be found here https://mecfsconference.org.au/videos/paulfisher/ If I may, I would like to encourage you to...

Ok I’m confused here. Is the suggestion here that A) Paul Fisher’s data https://www.s4me.info/threads/video-emerge-symposium-2019-dr-paul-fisher-specific-mitochondrial-respiratory-defects-compensatory-changes-in-me-cfs-patient-cells.9177/ are incorrect OR B) These data are correct but that...

https://forums.phoenixrising.me/threads/article-about-new-potential-treatment-by-victoria-bohne-in-norwegian.44871/page-9 Company web site no longer active apparently.

https://pubs.acs.org/doi/10.1021/acs.nanolett.8b04148 Golden Exosomes......... Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders

@Simon M Thanks for summary and thanks for pointing out difference between serum and plasma. More here https://microbiologyinfo.com/difference-between-serum-and-plasma/ https://www.westlab.com.au/blog/2018/07/27/what-is-the-difference-between-plasma-and-serum Plasma has fibrinogen, but...

FYI https://www.nytimes.com/2019/04/13/health/implant-brain-injury.html?action=click&module=Discovery&pgtype=Homepage Wonder what the cost is.... Surgery done at Stanford

Cipro info is interesting. Cipro is reported to cause cfs or cfs like syndromes. On the other hand someone on here reports that they improve on one of the flox antibiotics (levaquin). So maybe the levaquin results in a shift of the production of exomes to ones that are bad albeit less bad than...

@Cinders66 I think this is an important point and is confusing. Earlier Phair has stated on PR that he doesn’t think energy production is a thing in ME/CFS.

Journal of Extracellular Vesicles! I can’t believe I don’t have a subscription to this one yet.....getting my credit card ready.....

Speaking of microglia... Microglia, cells thought restricted to central nervous system, are redefined in new study https://www.sciencedaily.com/releases/2019/04/190404161007.htm

We like grumpy old crusts......

The word "Neuroinflammation" has been used in about half the talks so far and will be used again extensively tomorrow. I know @Jonathan Edwards has said there is no evidence of NI in CFS, only microglial activation. Should speakers be asked to define NI? Advice @JaimeS ? If there is no NI...

Nice that this finally came out....Kudos to F&M et al. to seeing this through. And now hopefully their cyclophosphamide study will be published shortly.....