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I wonder if this might have some bearing on the low ESR's (red blood cell sedimentation rates) sometimes reported in ME patients. The speed of RBC sedimentation is related, in part, to the red blood cells forming "stacks," which makes them heavier, leading them to fall faster in the...

My understanding of this [which might be horribly wrong...] When signaling in the brainstem becomes weaker, certain nerve fibers in the white matter carrying the signals become better insulated (with more myelin), so as to carry the weaker signals as fast as possible. This presumed compensation...

The idea of taking someone's allegiance for granted reminds me of this old joke (apparently originating in MAD Magazine in 1958)... Lone Ranger: "Look, Tonto, thousands of hostile Indian warriors coming right at us! How do we get out of this?" Tonto: "What do you mean "we," Kemosabe?"

BMC Neurol. 2005 Dec 1;5:22. A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid. Baraniuk JN1, Casado B, Maibach H, Clauw DJ, Pannell LK, Hess S S. http://www.biomedcentral.com/1471-2377/5/22 Anthony Komaroff summarized the findings of that paper before the Massachusetts...

There are a lot of variations on this, including, "I have not failed. I have just found 10,000 ways that won't work." It's unclear if he actually said this, though. During Edison's life, however, a colleague quoted him as responding to a question about a lack of results with,"‘Results!' Why...

Yes - and I'd go as far as to say that there is nothing that could ever lessen the esteem in which I -- how shall I say it? -- hold the Mayo.

Very encouraging. I'm a little surprised that they will only be taking a baseline and a 24-hour post-exercise blood sample. The Lights' exercise/gene expression test took a baseline and four other blood samples - at 30 mins, 8 hours, 24 hours and 48 hours, which allowed them to see a sort of...

Yes, it would be interesting to see the results if the patients had been told to answer the questions as they would have in the year before they got ME.

I suppose sometimes dry eyes are just dry eyes, but they are connected to a variety of conditions, including autoimmune diseases. They're also connected to inflammatory bowel diseases like Chron's and chronic ulcerative colitis (which seem to show gut microbiome distributions similar to those...

To paraphrase Time Bandits: "Oh, Psychology... Dear Psychology, you are so mercifully free of the ravages of perfectionism."

C'mon! Who'll help me carve the holiday cricket roast! I'll flip you for the thorax! Anyone?

Since they evaluated patients who already had CFS, I don't think they can tell whether their findings represent a potential predisposition or are rather a consequence of the disease. To see if PD's were a predisposition, they'd need to do a prospective study of a group of otherwise healthy...

Seems like the US and UK already are among the nations with the longest life-expectancy. If you assume that maximum lifespan is not all that elastic, the rate of increase is eventually going to slow down for those already near the top. Personally, I'm packing my bags for Monaco.

Merged thread David Tuller: Trial By Error: Mayo Still Champions GET Perhaps you're thinking of Bing Crosby as kindly old Dr. Cook in the 1971 telefilm "Dr. Cook's Garden." Of course, it turns out that kindly old Dr. Cook is surreptitiously euthanizing all the "bad" people in town, "weeding...

You get a different image when you search for ME or CFS on Bing.

I'm not sure how common (or relevant) this is, but, in the first couple of months following onset, I lost my appetite and a lot of weight. Part of it may have just been a reaction to feeling ill, but I suspect it also had to do with the fact that I suddenly got odd reactions to eating most...

This is the problem. The Mayo Clinic is renowned for succeeding where others fail - for being the court of last resort that will find the correct diagnosis/treatment, no matter how obscure. That's all great, but it no doubt makes it doubly difficult for them to believe, let alone admit, that...

It could one, or the other... or both. But I'm not locked into that. ;)

Given it's The Mayo Clinic, I would just apply Occam's razor and put it down to good old-fashioned hubris, the same condition that the CDC suffered from for three+ decades with regard to ME.

I question those who say there is no proof that there are people who refuse to accept that there are skeptics who don't believe in denialism. :)