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(So they did X chromosome analysis? ) I thought the point was that one of the X chromosomes in females issilenced, but the silencing is incomplete so that there is a double dose (or more than a single dose) of some genes?

Thanks, I appreciate the feedback because that's whet I try to do - make this pretty technical stuff understandable to those who don't have the technical knowledge but have the illness and want to understand the research. And thanks to all those who have left similar feedback (or just kind words).

I don't read much poetry, but I love what you write. I love how you can distill so much into so few words – and above all, how you capture the emotions and experience of living with this illness. And how you describe your own. Thanks so much.

Yes, according to Chris. Although it's qualified by this kind of long-Read sequencing that also picks up epigenetic signals. It is, astonishing, though and something to celebrate. Sorry for the ambiguity – I was saying that the samples are good to go. Which obviously saves a huge amount of...

It wouldn't, because of the samples. And thanks re video - credit to @Adam pwme for the video creation. My thanks for his work and his patience (animations from Oxford nanopore, words and any errors by me), Thanks. Does this work? This is an extraordinary moment for ME/CFS. It used to get by on...

DNA sequencing study to help pinpoint biology of ME gets £4.7m The science of Sequence ME and Long Covid The UK government has awarded nearly £5 million to fund full sequencing of the DNA of 6,000 people with ME using the best available technology. This will help scientists home in on what is...

The award is from the Office for Life Science, and I Think Part of Its Remit Is Promoting Innovation in Healthcare. I understand from Chris Ponting) that this will be the largest full genome sequencing a single disease so far. Suddenly, ME/CFS is moving from the back of the queue to being at...

That is seriously impressive. Congratulations. That's interesting. Charities don't usually like restricting donations in this way but for such an important study like this, it make sense.

My understanding is that the responder was not shown any options - they just state the illness, and the nurse chooses the option. Maybe chronic fatigue was incorrectly coded as CFS. CF has various estimates, but 4% isn't far off. Also note that the average age of the cohort at recruitment, the...

Thank you, @dave30th, this is a great video.

Me too. It was great to work closely with her and Charlie Hillier @chillier on the study – they are an impressive team.

Thanks for all the great work on this, @forestglip I'm finding it pretty hard to interpret the findings for several reasons: - Many previous studies didn't find a bimodal pattern, and with out digging in to them, it's hard to be sure why that was. - there seem to be differences by sex - and also...

I think a lot of us rely on and appreciate your forensic analysis of papers. I'm sorry that's so many of them are unrewarding for you, But at least we know that certain studies aren't useful (sadly, a very common state of affairs). Thank you for what you do. I can see why the particular study...

There will certainly be some post viral fatigue cases in this sample. We also see the same pattern of age peaks in mid teens and late 30s it in DecodeME, which also recruited via social media but had a decent question to screen for PEM in addition to requiring a diagnosis. And the same pattern...

That's true in some cases, less so in some others, such as the Norway. They diagnose about 1,500 a year from a population of around 5 million (equivalent of about 18,000 a year in the UK). And we know from NHS data (Samms & Ponting) that there are 100k diagnoses in the NHS HES database. That...

That was what stunned us, and makes the case more compelling. The data looks very different for Sweden and Norway (the former has a much smaller early peak), yet all the countries have very similar peak onset ages. Yes, that's likely. But how would that selection bias produce such an unusual...

Please do post any corrections, And can anyone advise me on how to include small photos of team members in the original Wordpress blog? When I tried to add them, they appeared huge on phone screens. Thanks. DMs appreciated.

And so has a blog about it. (Blog thread).https://www.s4me.info/threads/blog-me-cfs-onset-had-two-peaks-which-may-be-a-clue-to-causes.49797/

ME/CFS onset had two peaks, which may be a clue to causes New blog. (Formatted paper. Thread) A new study strengthens the findings that ME/CFS is a disease with a highly unusual feature. Analysis of survey data on patients across Europe found there are two peak ages for getting ME/CFS, around...

What about the UKB Biomolecule study? ME/CFS ideal, but they did focus on those with the strongest case definition.