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Looks like the B cells came back but the disease causing antibodies did not: ANALYSIS OF ANTIBODY REPERTOIRE Analysis of autoantibody repertoire in patients with SLE showed seroconversion of antibodies against dsDNA, single-stranded DNA, secondary necrotic cells, nucleosomes, and Smith protein...

SHORT- AND LONG-TERM EFFICACY After CD19 CAR T-cell administration, patients were regularly monitored for their disease activity. All eight patients with SLE met LLDAS criteria and had DORIS remission after 6 months (Figure 1A). Their SLEDAI-2K score was equal to zero after 6 months. Analysis of...

CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up Fabian Müller, M.D., Jule Taubmann, M.D., Laura Bucci, M.D., Artur Wilhelm, Ph.D., Christina Bergmann, M.D., Simon Völkl, Ph.D., Michael Aigner, Ph.D., Tobias Rothe, Ph.D., Ioanna Minopoulou, M.D., Carlo Tur...

I've been dreading this paper for 8 years. I'm surprised it's turned out to be worse than my most pessimistic expectations. I just assumed they’d find nothing (which they did) and quietly move on. Instead they wrote a dissertation-length diatribe about us.

BPS have never compared us to real psychiatric disorders that have a physical basis like schizophrenia and depression. They have put us in a special category of “nothing wrong with you, just imagining you’re ill”. No one would say that to a person with a recognised psychiatric syndrome. Just us...

By the way, rtx doesn't do anything for ME/CFS. There was a Phase 3 trial that showed no effect and huge placebo response.

Agreed. This lack of inflammation has been known for decades.

Merryn’s mother and Maeve’s father spoke very well. I would have been in bits trying to get the points across but they did great while faced with huge grief. Like many others, I kept waiting for the other shoe to drop and see SW or one of his minions burst on stage in a clown costume to explain...

Previous discussion regarding the dangers of long-term corticosteroid treatment: https://www.s4me.info/threads/critical-of-past-research-cortisol-studies.19175/

I'm wondering how you came about to be prescribed this high dose of I assume prednisone? Do you have an ME/CFS diagnosis or a recognised autoimmune disorder?

This questionnaire can't distinguish between depression, other medical disorders that cause fatigue and CFS IMO. All those symptoms listed are totally non-specific and would be answered yes by people with any number of chronic health conditions.

So, to sum up this study, we measured 4 metabolites in your body. They were normal. Therefore, you are mentally ill.

Paper published in a top psych journal in 2014 (not 1950), with 12 participants and far-reaching pro-Freud conclusions, point-blank admitting in the first sentence that hysteria is a synonym: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/1780023 Reference 1 is Stone's FND...

It's one of the most insane threads we ever had here, the sheer insanity of that paper and its conclusions. This person literally spent their last days/weeks/months on earth being told they have FND.

Does it come out ok that way for you? I never seem to be able to get it right in the microwave.

Selection bias, low sample size.

Definitely. The goal of science is to lay waste to superstitious nonsense, not help amplify it and wrap it in pseudoscientific jargon. SW and the likes of him took the worst of human nature (magical beliefs about thoughts etc.) and spun a pseudoscientific discipline out of it in 1980s. It...

Yes, this is a common clinical situation. "Functional" is understood by everyone in medicine to be a codeword for psychological. However, in my post I was referring to elite FND scammers who talk a good talk about how all that Freudian conversion stuff is superseded and how enlightened they are...

According to Stone, one of the leading proponents of FND diagnostic creep, pretty much every symptom, including memory issues, dizziness, weakness, chronic pain etc., is FND.

It's not clear from the comment if the NIH paper found anything in relation to cholinesterase or if this is just speculation based on the finding of sympathetic overactivation and what could be causing that.