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Deconditioning after five years? What are these people smoking! Deconditioning hits within days. Everything about this crappy 17 person study has been a despicable disgrace.

Not in the slightest. Many of us here warned about Walitt from day 1. I regarded this study as dead on arrival.

As expected, they’ve found nothing and they’ve ended up in an open access journal.

Proteomics with 19 subjects. Fuck me.

I’m sorry to be harsh but it’s 2023 and we’re still dealing with joke open label studies with no control group. An impressive looking magnet is bound to bias the patients somewhat, eh Mr Researcher?

This is incorrectly analysed. The abstract doesn't present statistical difference between the groups.

LDN doesn't work based on numerous anecdotal reports, as pointed out by @Perrier. This is a UK-heavy forum where (useless) treatments are generally not available due to socialised medicine. For those of us in other countries who have tried all sorts of meds including LDN, this is a big...

Kaufman is the same guy who was previously convinced about Valcyte, antibiotics, rituximab etc. Seemlessly moving from one idiocy to the next.

A pre-announcement announcement. :rolleyes:

You could probably achieve better blinding in tricyclic trials with an anticholinergic antihistamine serving as the placebo but they never do it.

Can’t really maintain blinding in placebo-controlled trials of tricyclics because they have such obvious characteristic side effects (dry mouth, drowsiness).

No because the homeopathic dose prescribed in this trial (10 mg) is 10x lower than what’s needed to achieve an antidepressant effect.

Having a horrible illness is a risk factor for depression. Shocking.

There is actually no reliable evidence that GET cures OI without PEM either. Studies in that area suffer from huge dropout rates and other problems.

I hear you. My EF is shot and I have no working memory. My digit span is like zero.

Can’t read this awful essay as it’s behind a paywall.

Since developing ME/CFS and POTS, I can't hold my breath for even 5 seconds without huge discomfort.

The sheer brazenness of this woman suing Data Colada. This sort of "fake it till you make it" attitude is very much encouraged in organisational psychology / business circles.

As we all know, a subset of patients have disordered breathing which has been a fertile ground for proliferation of psych theories and interventions. This hypothesis paper addresses what it thinks are the causes of hyperventilation from a different angle. Key section: Fig. 2. Putative...

It's the same 5 people flooding journals with the same article rewritten 100 times.