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Some more background info: Source: https://neuroscientificallychallenged.com/posts/know-your-brain-striatum

This is a review but links to the various papers which have evidence for the concepts discussed. Some areas seem speculative. Others more clear. But there’s some interesting ideas discussed which seem to useful to various discussions including those in this thread on butyrophilin-like genes...

Thanks again, good to hear all this. I need to read all the discussion here properly but have been wondering about the reported changes in NK function or talk of ‘exhausted’ NK cells and if this was more a case of them just being different. And on possibly relevowith Fluge and Mella’s work...

Power of Memory: A Natural Killer Cell Perspective Sinha, Oishi; Abhipsha, SK; Sen Santara, Sumit Abstract Memory is an incredible aspect of our immune system. Similarly to our cognitive memory, it allows us to remember and respond more efficiently to subsequent encounters with the same...

Thanks Jonathan this is all really useful. Over recent months I’ve been reading some papers about memory or memory like NK cells, which after exposure to cytokines can hang around for a long time with lower thresholds for activation. I’m not sure if this ties in with the behaviour you mention...

Catching up partially here, but would BTN2A1 tie in more with the idea of a sort of innate autoimmune condition rather than adaptive? Are autoimmune conditions normally seen as adaptive? Is there such a thing as innate autoimmunity? I’m thinking along the line of longer lived memory NK cells.

Thanks!

Thinking some more about brain regions to look at, rather than focusing on where CA10 is relatively highly expressed, maybe looking at where other genes are too may be worthwhile? For that, best look at the whole heatmap for DecodeME and squint a bit...

There’s apparently a known sex bias in the occurrence of allergies too, something which popped up listening to this https://www.bbc.co.uk/sounds/play/m001byym When younger, males show more allergies, but during puberty this changes and females catch up then overtake, with women more likely to...

Very impressive! Looks like a great resource, thanks for all your work @tralfamadorian97 and for sharing it.

An interesting review of sex differences and IFN responses including discussion of NK cell impact. In short, stronger type I IFN responses from higher TLR7 expression due to chromosome differences which also has an impact on CD8+ T cells. Sex hormones, estrogen and progesterone, also have an...

Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity Pujantell, Maria; Altfeld, Marcus Abstract The immune system protects us from pathogens, such as viruses. Antiviral immune mechanisms aim to limit viral replication, and must maintain immunological...

That’s a good point @Utsikt talking about neurological conditions and some of these topics could worry people. The way I see it we can have these genes or pathways involved or implicated by them involved in ME/CFS without any need for ongoing tissue damage or a degenerative condition. It’s a...

HTT and spiny neurons seems maybe worthy of more investigation, they seem very interrelated. It’s not a gene I think we spent much time on but was one of the DecodeME candidates even if a bit below the threshold. LocusZoom for HTT.

First bash at working with the brain tissue specific data and the DecodeME geneset is here https://dev.decodemebrainregions.pages.dev/ Using the same pipeline I did before but with different preprocessing step from that used with GTEx to get the tissue expression data. I can't be sure that my...

It’s all been happen hasn’t it! And welcome to the forum @James Cox great to have you here! I think we’re all looking forward to seeing what any research you’re involved in shows up. The only tissue expression stuff I’ve looked at so far has been very broad using GTEx data and looking at...

Ah gamma delta T cells. Got it thanks! So many acronyms.

What are gdT cells?

Really interesting, thanks for this @ME/CFS Science Blog A great overview and explanation woth some really interesting ideas. I Also hadn’t twigged the use of a special dataset looking more narrowly at tissue expression in the brain. The Brain Atlas looks very useful and I wonder if I can try...

But they need not even have a direct influence, there could be an intermediary right? Some other signalling molecule for instance, interferon. I really do think there could be something here that helps fill in part of the picture, one of a few jigsaw pieces that will fit together and show us...