AIx@75 Augmentation index normalized to a heart rate of 75 bpm
MFI Microvascular flow index
OCT Optical coherence tomography
PAT Peripheral arterial tonometry
PPV Proportion of perfused vessels
RHI Reactivehyperemia index
TVD Total vessel density
Microcirculatory impairment and increased arterial stiffness in pediatric Long COVID patients
PURPOSE
The exact pathogenesis of Long COVID remains unclear. Microvascular and endothelial dysfunction, established contributors to SARS-CoV-2-related conditions, appear to play a role in pediatric...
https://neuroimmune.cornell.edu/research/participant-interactions/
Participant Interactions
We are seeking volunteers comprising 40 ME/CFS patients and 20 controls to participate in this NIH funded (U54AI178855) project. The ME/CFS subjects will be identified by expert physician Dr. Susan...
Week beginning 30th December 2024
:emoji_blossom: Happy New Year to all our readers :emoji_blossom:
News, articles and advocacy
ME/CFS Skeptic
Blogger ME/CFS Skeptic has written an excellent overview of the most interesting ME/CFS research studies of 2024. Studies discussed range across...
Research objectives
1. To study the prevalence of ME/CFS according to its diagnostic criteria among patients with chronic fatigue associated with PCS.
2. To determine the signs of dysautonomia based on the analysis of heart rate variability (HRV), blood pressure variability (BPV), and...
Background
Post-acute COVID-19 syndrome (PACS) has been linked to microvascular endothelial dysfunction as a potential underlying pathomechanism and can manifest even following a mild course of the initial infection. Prevalence of microvascular endothelial dysfunction and circulating natriuretic...
Abstract
The near-infrared spectroscopy (NIRS) vascular occlusion test (VOT) assesses microvascular reperfusion. Two strategies have been employed to quantify reperfusion following reactivehyperemia, but it is unclear if both yield similar results when comparing biological sex.
Purpose...
This is the study they cite for promising results in post-COVID condition:
Preventive effects of Pycnogenol® on cardiovascular risk factors (including endothelial function) and microcirculation in subjects recovering from coronavirus disease 2019 (COVID-19)
"BACKGROUND: The aim of this open...
Long-Term Microvascular Changes in Multisystem Inflammatory Syndrome in Children
Julie Boever; Claudia Nussbaum; Leonie Arnold; Nikolaus A. Haas; Simone K. Dold; Felix S. Oberhoffer; André Jakob
No Abstract.
Videos of sublingual microcirculation were obtained with a handheld MicroScan video...
Abstract
Post-exercise hypotension (PEH), calculated by the difference between post and pre-exercise values, it is greater after exercise performed in the evening than the morning. However, the hypotensive effect of morning exercise may be masked by the morning circadian increase in blood...
The self-report has patients less sedentary, doing more light physical activity, a little more moderate physical activity, with both LC and HC doing a little vigorous physical activity. Not much difference between groups on objective actigraphy, but as @EndME points out above there is a large...
Non-invasive measurement of SvO2 would be helpful in sepsis / cardiogenic shock etc. It might be helpful in LC/ME.
They referenced their device against arterial and venous direct O2 measurements in healthy young adults. The device they were assessing was on the fingertip like the usual...
Abstract
Many individuals who had COVID-19 develop detrimental persistent symptoms; a condition known as post-acute sequelae of COVID-19 (PASC). Despite the elevated risk of cardiovascular disease following COVID-19, limited studies have examined vascular function in PASC with equivocal results...
Week beginning 30th January 2023
News, articles and advocacy
UK - Scotland There was a debate in the Scottish parliament on the "Scottish Government Commissioned Review of ME Services and Future Action". The review from July 2022 raises the need for GP education and recommends setting up pilot...
Endothelial dysfunction in ME/CFS patients
Sandvik MK, Sørland K, Leirgul E, Rekeland IG, Stavland CS, Mella O, Fluge Ø
Objective: A few earlier studies have found impaired endothelial function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The present study...
Endothelial dysfunction and FMD responses to nitric oxide are of interest in ME/CFS e.g
from Fluge, Mella and Tronstad's 'Pathomechanisms and possible interventions in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)' paper.
Full title: Sulodexide Significantly Improves Endothelial Dysfunction and Alleviates Chest Pain and Palpitations in Patients With Long-COVID-19: Insights From TUN-EndCOV Study
Objective: Non-respiratory long-coronavirus disease 2019 (COVID-19) symptoms are mainly related to a long-lasting...
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