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  1. forestglip

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Quote from another thread, but thought it'd be good to post this response here. I put the top 115 genes into STRING to see the connections between proteins. HLA-C only has evidence linking it to one other protein with medium confidence, PSMB5. The same graph in interactive form can be seen...
  2. forestglip

    [EV] proteomics uncovers energy metabolism, complement system, and [ER] stress response dysregulation postexercise in males with [ME/CFS], 2025,Glass+

    The search engine AIs are very bad with hallucinations, much worse than the stand-alone chatbots. I wouldn't ever trust the Google Search AI without checking its sources. I mean that's good practice with any AI, but I feel like with the search AIs it's basically a coin flip whether it just makes...
  3. forestglip

    [EV] proteomics uncovers energy metabolism, complement system, and [ER] stress response dysregulation postexercise in males with [ME/CFS], 2025,Glass+

    That's kind of surprising. Are you sure you don't have any kind of custom instructions referring to ME/CFS that could influence it to answer in this way?
  4. forestglip

    Evaluating the Causal Role of Genetically Inferred Immune Cells and Inflammatory Cytokines on ME/CFS, 2025, Duan et al

    This looks very similar to another recent study that was on PVFS: Causal relationship between immune cells and post-viral fatigue syndrome: a Mendelian randomization study, 2025, Wang et al They both used the same 731 immune traits from a separate GWAS, although this thread's study also looked...
  5. forestglip

    [Poster] Changes in blood metabolic profile during repeated cardiopulmonary exercise testing (2xCPET) in ME/CFS patients, 2025, Chapola

    I don't know what this abstract is from. It came up on Google Scholar, but I can't find a mention of it anywhere else.
  6. forestglip

    [Poster] Changes in blood metabolic profile during repeated cardiopulmonary exercise testing (2xCPET) in ME/CFS patients, 2025, Chapola

    Changes in blood metabolic profile during repeated cardiopulmonary exercise testing (2xCPET) in ME/CFS patients Henrique Chapola, Katarina Lien,, Sissel Dyrstad, Per Ole Iversen, Karl Johan Tronstad [Line breaks added] ME/CFS is characterized by post-exertional malaise (PEM) and delayed...
  7. forestglip

    [EV] proteomics uncovers energy metabolism, complement system, and [ER] stress response dysregulation postexercise in males with [ME/CFS], 2025,Glass+

    Thank you for the color coding. What a good idea for quickly seeing matches. Adds some colorful decoration to the thread as well.
  8. forestglip

    [EV] proteomics uncovers energy metabolism, complement system, and [ER] stress response dysregulation postexercise in males with [ME/CFS], 2025,Glass+

    The proteins enriched in the neutrophil pathway at baseline were PSMA5, RAP1A, KPNB1, TXNDC5, RAB7A and at 15 minutes post-exercise were ERP44, RAP1A, GSTP1, DSG1, TXNDC5. All lower in ME/CFS EVs. Neutrophils were a hot topic in the study from a few days ago: Preprint Charting the Circulating...
  9. forestglip

    [EV] proteomics uncovers energy metabolism, complement system, and [ER] stress response dysregulation postexercise in males with [ME/CFS], 2025,Glass+

    Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson [Line...
  10. forestglip

    News from PrecisionLife Ltd.

    Bio-IT World: 'A Practical Precision Medicine Approach to Complex Chronic Diseases' ---- 'Based on unpublished data, the “strong expectation” of investigators is that all nine of the genes thought to be common to ME/CFS and long COVID will be a reproducible finding. The All of Us dataset used...
  11. forestglip

    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    Ah yeah, YouTube guessed meltsey and Claude guessed that meltsey meant ME/CFS from context. I tried another method of getting the auto-generated Norwegian subtitles and asking Claude to do the translation as well. I was adamant that it should not change content and to put anything it wasn't sure...
  12. forestglip

    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    In defense of the AI, I think the issue is with the YouTube auto-translation. These are the subtitles:
  13. forestglip

    Open Norway: Plasma cell aimed treatment with daratumumab in ME/CFS - Haukeland University Hospital

    I used this website to get those auto-translated subtitles, then I asked Claude Sonnet 4 to format it nicely and fix any typos without changing the content: Edit: Better translation below.
  14. forestglip

    Preprint Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights, 2025, Hoel, Fluge, Mella+

    HLA-C has the 39th highest fold change out of the 7326 aptamers they tested (logFC = 0.35). Not significant though (p=.19, q=.45). Here are all the ones they tested that mentioned HLA: Edit: Mistyped the q-value.
  15. forestglip

    [Transcriptome] in PBMCs of [LC] at a median follow-up of 28 months [...] reveals upregulation of JAK/STAT [...], 2025, Fineschi et al

    Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...
  16. forestglip

    Updates from the UK ME/CFS Biobank / CureME team

    Email from IACFS/ME: ---- Dear IACFS/ME Supporters, We would like to share with you the following message from Caroline Kingdon, RN, MSc, at the UK ME/CFS Biobank. If you have any questions please send them directly to the Biobank via the links below. Sincerely, IACFS/ME...
  17. forestglip

    Are gallbladder problems a common secondary symptom in ME/CFS ?

    I think the title and post are missing the symptom. Edit: I see you put cholecystitis as a tag. I assume that's the symptom.
  18. forestglip

    Trial Report Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy, 2025, Ruan et al

    Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy Brian T. Ruan, Sarojini Bulbule, Amy Reyes, Bela Chheda, Lucinda Bateman, Jennifer Bell, Braydon Yellman, Stephanie Grach, Jon Berner, Daniel L. Peterson, David Kaufman, Avik Roy...
  19. forestglip

    What research do you want to see? (study ideas)

    Maybe it'd be good to do a study that gives people a list of many diseases, including ME/CFS and long COVID, and asks if they have heard of each one. Maybe binary response or maybe multiple choice like "Never heard of it", "I've heard the name but don't know what it is", and "I know what it is"...
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