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Quote from another thread, but thought it'd be good to post this response here. I put the top 115 genes into STRING to see the connections between proteins. HLA-C only has evidence linking it to one other protein with medium confidence, PSMB5. The same graph in interactive form can be seen...

The search engine AIs are very bad with hallucinations, much worse than the stand-alone chatbots. I wouldn't ever trust the Google Search AI without checking its sources. I mean that's good practice with any AI, but I feel like with the search AIs it's basically a coin flip whether it just makes...

That's kind of surprising. Are you sure you don't have any kind of custom instructions referring to ME/CFS that could influence it to answer in this way?

This looks very similar to another recent study that was on PVFS: Causal relationship between immune cells and post-viral fatigue syndrome: a Mendelian randomization study, 2025, Wang et al They both used the same 731 immune traits from a separate GWAS, although this thread's study also looked...

I don't know what this abstract is from. It came up on Google Scholar, but I can't find a mention of it anywhere else.

Changes in blood metabolic profile during repeated cardiopulmonary exercise testing (2xCPET) in ME/CFS patients Henrique Chapola, Katarina Lien,, Sissel Dyrstad, Per Ole Iversen, Karl Johan Tronstad [Line breaks added] ME/CFS is characterized by post-exertional malaise (PEM) and delayed...

Thank you for the color coding. What a good idea for quickly seeing matches. Adds some colorful decoration to the thread as well.

The proteins enriched in the neutrophil pathway at baseline were PSMA5, RAP1A, KPNB1, TXNDC5, RAB7A and at 15 minutes post-exercise were ERP44, RAP1A, GSTP1, DSG1, TXNDC5. All lower in ME/CFS EVs. Neutrophils were a hot topic in the study from a few days ago: Preprint Charting the Circulating...

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson [Line...

Bio-IT World: 'A Practical Precision Medicine Approach to Complex Chronic Diseases' ---- 'Based on unpublished data, the “strong expectation” of investigators is that all nine of the genes thought to be common to ME/CFS and long COVID will be a reproducible finding. The All of Us dataset used...

Ah yeah, YouTube guessed meltsey and Claude guessed that meltsey meant ME/CFS from context. I tried another method of getting the auto-generated Norwegian subtitles and asking Claude to do the translation as well. I was adamant that it should not change content and to put anything it wasn't sure...

In defense of the AI, I think the issue is with the YouTube auto-translation. These are the subtitles:

I used this website to get those auto-translated subtitles, then I asked Claude Sonnet 4 to format it nicely and fix any typos without changing the content: Edit: Better translation below.

HLA-C has the 39th highest fold change out of the 7326 aptamers they tested (logFC = 0.35). Not significant though (p=.19, q=.45). Here are all the ones they tested that mentioned HLA: Edit: Mistyped the q-value.

Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...

Email from IACFS/ME: ---- Dear IACFS/ME Supporters, We would like to share with you the following message from Caroline Kingdon, RN, MSc, at the UK ME/CFS Biobank. If you have any questions please send them directly to the Biobank via the links below. Sincerely, IACFS/ME...

I think the title and post are missing the symptom. Edit: I see you put cholecystitis as a tag. I assume that's the symptom.

Requested to be posted by @Utsikt.

Low Dose Rapamycin Alleviates Clinical Symptoms of Fatigue and PEM in ME/CFS Patients via Improvement of Autophagy Brian T. Ruan, Sarojini Bulbule, Amy Reyes, Bela Chheda, Lucinda Bateman, Jennifer Bell, Braydon Yellman, Stephanie Grach, Jon Berner, Daniel L. Peterson, David Kaufman, Avik Roy...

Maybe it'd be good to do a study that gives people a list of many diseases, including ME/CFS and long COVID, and asks if they have heard of each one. Maybe binary response or maybe multiple choice like "Never heard of it", "I've heard the name but don't know what it is", and "I know what it is"...