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  1. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Woohoo! Sunday has been a success. Thanks Jonathan and thank you to the greek gods of qeios for the extra time to digest information. This is all sounding very intriguing…
  2. hotblack

    Learning about the immune system

    A couple more useful bits, I don’t seem to be able to edit my earlier post to add them now but… Bite Sized Immunology Phagocytosis https://www.immunology.org/public-information/bitesized-immunology/systems-processes/phagocytosis Complement System...
  3. hotblack

    Learning about cell biology

    If you’ve been through the immunology basics and know what a phagocyte is but want to understand more about some of the processes they and other cells use are here are some resources. If you don’t know what a phagocyte is start here or check out the thread on Learning about the immune system...
  4. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Aha, receptor mediated endocytosis? Or am I suffering from ‘thing I just learnt about’ syndrome? edit: since this seems relevant, a description of this can be found here and I’ll post more in the Resources forum
  5. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    I have been re-reading with more sleep and time to compost things. If I’m understanding the explanation… Macrophages are more likely to trigger because this FcgRI receptor has been bound to by an antibody? It’s sort of ‘primed’ by it? And this receptor is/can be expressed more when T cells are...
  6. hotblack

    Visual media for learning biology/medicine

    For the basics of T cells, B cells etc I’ve found the Khan Academy stuff in the other resource threads pretty good overviews. I’m not so sure about the visual aspects as I tend to just listen.They don’t seem to do the fluff to make things ‘engaging’ you get in some places. My feeling is if...
  7. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Thanks for the clarification Jonathan. I’ll sit back and wait for the full reveal of The Conspiracy of the Leukocytes
  8. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    I should probably wait and go through the paper but if I’m understanding the summary (and I may not as I woke up at half 4 his morning)…. Some B cells create an antibody which binds to this specific receptor (Fc-gamma-RI) on certain cells, which means T cells get interested and fire off messages...
  9. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    Just starting it off or also aggravating them some more? Would or could this theory explain why some immune triggers (illness or vaccination for example) also trigger worsening for some people?
  10. hotblack

    Notice about a forthcoming paper: A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma

    I think FC Gamma RI (also called CD64 amongst other things) is a type of FC receptor Wikipedia entry Genecard Also see the wikipedia description of Fc gamma receptors
  11. hotblack

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Understood @jnmaciuch I look forward to hearing if/when you have something more to share :)
  12. hotblack

    Using Heart rate monitoring to help with pacing.

    I saw this pop up in my alerts and thought the same so gave up. My chain of thought went “heart rate analysis looks interesting, is this a paper or something else, experimental poetry, what?” Grain is a literary magazine in Canada.
  13. hotblack

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    I’d echo that. Or post threads using threadreader or something without any barriers? I haven’t been on twitter for many years and won’t be signing up just to read things as you seem to need to do these days.
  14. hotblack

    Impact of COVID-19 & 2021 NICE Guidelines on Public Perspectives Toward ME/CFS: Twitter Analysis, 2025, Khakban et al (Jason Busse)

    This would be funny if it wasn’t so pathetic. It’s sentiment analysis on twitter, lol. Not going to waste any energy reading or thinking about it. I will add they used RoBERTa for the sentiment analysis, this is an old and small mode based on Google’s BERT. Maybe it’s good in specific...
  15. hotblack

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Are you thinking generally @jnmaciuch or that this is an issue in specific places? Say, issues around degradation of neurotransmitters or other proteins by the proteasome around the synapse?
  16. hotblack

    ME/CFS as a biological information processing problem

    I’ve wondered that. There seems to be at least a genetic predisposition. Could there be a natural development towards it to? Perhaps with people pushed over an edge by an illness if not that illness being a trigger as has often been seen? I suppose some comes down to how you define these things...
  17. hotblack

    ME/CFS as a biological information processing problem

    This from another thread but… I was listening to descriptions of neurotransmitters and receptors and this was said Which seemed relevant here, with different people having different effects of drugs, varying symptoms etc. With a neuron having both excitatory and inhibitory receptors, perhaps...
  18. hotblack

    Comparing DNA Methylation Landscapes in Peripheral Blood from [ME/CFS] and Long COVID Patients, 2025, Peppercorn et al

    The platform SequenceME are hoping to use seems to do methylation detection I think. Oxford Nanpore had a conference this week and mentioned it along with other improvements to their platform, I caught some bits of announcements from it, but am not sure of all the details. relevant posts on...
  19. hotblack

    ME/CFS as a biological information processing problem

    With my new found knowledge of what a glial cell is (okay only roughly, at least I know different types exist) I have a question… Which type of glial cell are you thinking of here or more generally with the glial activation idea?
  20. hotblack

    Preprint Dissecting the genetic complexity of myalgic encephalomyelitis/chronic fatigue syndrome via deep learning-powered genome analysis, 2025, Zhang+

    Understandable. I’m sure we all have this concern to varying degrees. There are various things they could and probably will try. But it’s good we have the environment here and some good scientists with which we can explore it. And ultimately I think we’re best served by getting on with good...
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