Search results for query: pace trial

...that for many of us. None of this makes sense to me. I am a scientist by training. I don't need the lens of sociology to tell me that the PACE trial was fraudulent. I have decades of my own and my daughter's experience, as well as thousands of others testimony, showing me that for people...

You have now made it clear, Alan, that you have not actually understood the situation in this community. BPS is shorthand for a group of people who in the past have propounded a particular theory. What historically is not in doubt is that these people have proved incompetent, most obviously in...

Alan, no one is here to discuss your points about insular communities. many of us spent years or decades without any online communities, "illness narratives" (you know, because we HAD no narrative or even diagnosis) or illness identity, yet here we are, still sick. you want engagement with...

https://fleet.brainworks.ai/foundry/long-covid-wired-critique/ nice :thumbsup:

It's really something that describing this article as a "love poem" to mind-body ideology is just... fair. It's not an exaggeration. The starting point of the article was a clear and completely one-sided bias in favor of this flimsy, controversial belief system being unquestionably true, and...

Someone linked this video in another thread. Fantastic. 8 min simple explanation in simple words of simple facts in a friendly voice. Totally demolishes 90 % of psychosomatic research on ME/CFS.

Picking up on a few passages: The whole point about "fight or flight" is a survival advantage: sympathetic driven cardiovascular / respiratory / neuromuscular priming. It suppresses pain and fatigue signals: sometimes giving us extreme stories of eg people running from danger not even...

...see that the natural full recovery rate there (23%), which is all completely outside of any intervention trial, is higher than within the PACE trial (with more reliable estimates placing it under 10% and roughly the same as White's fantasy rates). Certain factors ought to play a role, such as...

...than expected from an irrelevant intervention or time. This is clinical science 101, as others have said. The remarkable thing about the PACE trial, if anything is how dismal CBT and GET seemed to be as placebos. Drugs that we now know don't work showed far better results in open studies...

Additionally, these studies and clinic interventions lack long term follow up, so there is no understanding that any short term recovery hasn't been sustained For example; https://www.actionforme.org.uk/wp-content/uploads/2025/04/Action-for-ME-FOI-report.pdf "Fewer than one in four NHS...

...criticism of mind-body interventions. If one views placebo effects as powerful and curative, then criticising studies like the PACE trial for lack of blinding may seem excessively harsh and the modest effects reported by these studies may be interpreted as indicating the treatment is useful...

Hence the accusations of bad faith.

Maybe if The Lancet and people like Adam Gaffney were willing to be honest about the PACE trial and acknowledge what is self-evident--that a trial in which participants can be "recovered" on key variables at baseline because the investigators dramatically weakened their outcome thresholds after...

With all due respect, I don't want to engage in dialogue with someone who patronizes me, tells me I am on the beginner's slopes, and to "do better." I have been unfailingly civil, listened, thanked people for welcoming me here, and demonstrated my familiarity with the history, the science, and...

...2 in the NIH study and some in the placebo and treatment groups in the rituximab studies and so on, and possibly some on all arms of the PACE trial. The difference seems to be that those who teach brain retraining seem to include as part of the package of the training course an obligation...

They are not difficult to do. PACE would have been a decent study if the researchers had reported the results honestly. It showed no long term benefit, but the researchers chose to pretend it did by highlighting within group comparisons rather than between groups which showed no difference from...

I wonder who you have been listening to. Almost every week it seems we see yet another poorly conducted trial of exercise or psych therapies for Long Covid. It's amazing how many teams seriously think they are doing new and groundbreaking clinical trials of yet another variation of CBT or GET...

Appreciate this thoughtful reply. I have to go now, and am logging off for the rest of the week/weekend, but a few quick points. First, I think studies of BPS interventions are simply very difficult to do, for the same reason that studies of any intervention that might depend on therapeutic...

That’s very different from what you said initially. Most diseases have people that get a lot better spontaneously. That says nothing about how the diseases work, except for that they are probably not degenerative. It’s really not difficult. Just stay away from the woo and present your findings...

...basic problems have not been discussed for example in the expert testimonies? I can understand that you worry that the history of the PACE trial makes it so that other BPS interventions (or whichever name you prefer) cannot be studied. I can assure you that is not the case. There have been...