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For those wanting to read more about Fluoroquinolones here is a good Nature article from last year about the situation https://www.nature.com/articles/d41586-018-03267-5?fbclid=IwAR0Q7RgVl4Ee-xgpk_lr08qPA5AqTSuQjX7lpuMFWxETs0KrShh-zZ2ApHE

Some of their earlier papers provides analysis at different frequencies. In this paper they comment on the component of real and imaginery components of the impedance and their effects and that the real or in-phase component has the biggest effect. This means that lower frequencies are probably...

@Hip Here is a recent tweet on hashtag popularity

Did you watch Neil McGregors recent talk - you might find it interesting as he retrospectively subtyped 777 patients by Glucose response and came up with 3 subtypes based on response 1. Flat (7%). 2. Truncated (83%). 3. Normal (10%) Link : https://mecfsconference.org.au/videos/neil-mcgregor/

Another suggestion for an experiment. Could cell membrane potential be measured before and after 2-3 hours of salt solution? Patch Clamps can measure membrane potential. The change in impedance observed could be related to the change in potential......... Seems like there are several different...

What is the salt doing? I wonder if this experiment is all about the cellular sodium/potassium pumps and their ability to use ATP to pump. If that is the case there must be other tests that can measure the functioning ability of these pumps, that may not have to rely on the nanoneedle in order...

Cellular sodium pumps seem to be an interesting topic. Anyone know more about them and perhaps relevance to this test? This is an interesting snippet I read I wonder if the above has anything to do with the nerve damage many have that results in small fiber neuropathy as measured by skin...

Good questions @Jonathan Edwards . I would love to learn more about the structure, how many sensors, when to capture a reading from a sensor.... could other structure geometries work better. I posted this yesterday in case you missed it. This previous paper talks more about the nanoneedle...

Karl Morten touched on blood handling issues and quick degradation in his NZ talk. I believe this was in relation to his work to try and validate the Myhill et al ATP profile test Transcript ...

I've only read the paper once, but it seems this test currently requires very custom one-off research equipment, and the test itself takes 3 hours to run, never mind all the before and after prep. So it's a slow, researcher intensive process. The 40 samples tested in the paper had to be tested...

@Jonathan Edwards Regarding "why" take a look at the citations from the author. I suspect someone decided just to try it because they'd worked on nanoneedle technology previously. Citation 38 might be relevant.... Nanoelectronic impedance detection of target cells (Dec 2013) Esfandyarpour et al...

Thanks for the great write-up @Simon M. I'm not sure they say the finding is unique to ME/CFS - you probably meant to write something a little different here.

@Jonathan Edwards This seems to be the experimental setup - measure electrical AC impedance of samples across 30nm electrodes over 3 hours. Samples were tested within 5 hours of collection - I imagine this very much limits sample size. Details from paper : Hope that helps.

There is some public 23andMe data posted here if it helps. https://my.pgp-hms.org/public_genetic_data?data_type=23andMe However there are at least 5 different versions of chips, and I couldn't find which one checks for that SNP.

There is a bit more info here https://www.snpedia.com/index.php/Congenital_adrenal_hyperplasia

According to this SNPedia page 23andMe miscalled rs7755898 https://www.snpedia.com/index.php/Rs7755898 However I checked the "Lilly Mendel" reference files and could not find this SNP. @mariovitali is your data 23andme?

Lets not forget Karl Mortens plasma swap too. This is slide 44 from his presentation in NZ. Thread on his presentation here https://www.s4me.info/threads/dr-karl-morten-oxford-university-lecture-in-new-zealand-about-his-research-december-2018.7287/

Two of the ten scientists on this project are from Stanford. http://med.stanford.edu/gbsc/nasa-twins.html One of them Mike Snyder is involved in the multi-omics work on ME/CFS at Stanford (Fereshteh Jahaniani leading the project is on his staff) as well as a recent scientific board member of...

Nooooooo. I've heard quite a few Australian researchers mention how essential he was with providing access to patient data and samples.

I know some of us are excited about the possible identification of "something in the blood" but lets remember that in Ron Davis's presentation he said it MAY be exosomes based on an experiment