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  1. Mithriel

    Reduced limbic microstructural integrity in functional neurological disorder, 2019, Diez et al

    Jonathan Edwards says This hits the nail on the head. They have now got research that shows signs that can be found in a straightforward neurological examination which indicates FND in the same way MS can be shown. Now they are showing changes in the structure of the brain using up to date...
  2. Mithriel

    Oxidative stress in exercise training: the involvement of inflammation and peripheral signals, 2019, Francesca et al

    I think that athletes who continually push their bodies beyond their energy production capabilities experience what we do when we push our bodies beyond our energy production capabilities. The difference is they push a healthy system to its limits while we struggle with an energy production...
  3. Mithriel

    Reduced limbic microstructural integrity in functional neurological disorder, 2019, Diez et al

    This is what worries me. The mixed FND implies that all the categories they call FND, ME to IBS and everything inbetween, shares a common pathology of emotional disorder so it is a confirmation they are right to treat them all as conversion disorder. They are saying that the only thing wrong...
  4. Mithriel

    Reduced limbic microstructural integrity in functional neurological disorder, 2019, Diez et al

    Yes, FND is claimed to be neurological problems with no physical deficits found, but now they are busy finding the physical signs in the brain for this "disease" that is purely psychological and behavioural. Doublethink is to weak a word to describe the mentality of these people. The cruelty...
  5. Mithriel

    Prevalence and Treatment of Chronic Fatigue Syndrome/ME and Co-morbid Severe Health Anxiety, 2019, Daniels et al

    I doubt if I am unusual but I actually have very low health anxiety compared to people I know. I am continually surprised when people rush to the doctor for a symptom I have had for years and just put up with. Any new symptom I get I assume is ME in the first place and then I do not want to go...
  6. Mithriel

    Abnormalities in the urine of people with ME/CFS? A clinician asks for feedback

    Thank you for your explanations. Since in ME we are easily in the situation of sustained exertion at near to maximal levels does this mean we get burning because of increased acidosis from pyruvate? Or is the buffering system overloaded? Deep burning pain after exertion, even in a fit person...
  7. Mithriel

    Abnormalities in the urine of people with ME/CFS? A clinician asks for feedback

    Off topic, but I had always thought the burning pain in my legs was due to a lactic acid buildup and one of the byproducts of anaerobic respiration was said to be lactic acid when I was teaching biology. There have been so many discoveries since that time, I wonder if you could explain about...
  8. Mithriel

    Inflammatory proteins are altered in chronic fatigue syndrome – a systematic review and meta-analysis, 2019, Strawbridge et al

    King's college (and Anthony Cleare who is presumably AJ Cleare) are BPSers. I think they do this work to show they are looking at biology, but, sigh, there is nothing much there despite the protests of patients. It may not apply here, not read the paper, but the problem with studies of immune...
  9. Mithriel

    ME Association: “Get Well Soon” – Guest Blog by Louise Shepherd

    My father died a week after his 50th birthday. He got lots of cards and it was obvious that people had taken great care not to send one that wished him a great year. The exceptions were the obvious ones like my scatty aunt and my granny who meant well but often missed :) I used to make a lot of...
  10. Mithriel

    The unifying diagnostic construct of bodily distress syndrome (BDS) was confirmed in the general population, 2019, Fink et al

    I am really glad you said this. It seems so obvious, here and in FND, that if you define an illness as BDS or FND (and how does that work :) do they talk to each other?) then a few years later or if you look at a large population then you will find the same categories. Then they say this...
  11. Mithriel

    Effects of mirthful laughter on pain tolerance: A randomized controlled investigation, 2019, Lapierre et al

    Wide spread burning pain is a good description of the myalgia part of myalgic encephalomyelitis. It is probably related to the waste products of anaerobic respiration, pyruvate and lactic acid. The association with widespread pain was lost when CFS was invented. That is when many people in the...
  12. Mithriel

    First evidence of immune response targeting brain cells in autism

    And a fortune in research money has gone into disproving that vaccines cause autism. Now they are managing to move on.
  13. Mithriel

    Mike Snyder at Stanford symposium on the potential of smartphones to better understand diseases, inc ME/CFS (Simon M blog)

    The overdiagnosis problem is because they look for indications not the actual disease. These sort of systems may actually prevent some of these problems. Of course the "downside" of breast cancer screening is often given as "women get themselves upset by being recalled" so the "woman as...
  14. Mithriel

    Harvard Medical School article: Chronic fatigue syndrome: Gradually figuring out what’s wrong. Komaroff. 2019

    I suspect that we are in a basic survival mode most of the time because our bodies do not have enough ATP because of the broken aerobic respiration system. The Workwell studies show that we rely on anaerobic respiration for our basic needs like using a credit card for everyday food. We do not...
  15. Mithriel

    Eating improves exertion induced fatigue and symptoms of orthostatic intolerance

    Type 2. I've always eaten a fairly healthy diet with not a lot of sugar, though I am overweight like many of us. I suspect that my pancreas is worn out with the strain of the continual hypoglycaemic due to the ME but who understands ME enough ... Diabetes care is well organized by the health...
  16. Mithriel

    Eating improves exertion induced fatigue and symptoms of orthostatic intolerance

    Without going into much detail, I had attacks like this for decades. Doctors were very scathing and saw it all as psychological. Now that I am diabetic I have a machine and know that I did have hypoglycemia all those years. The brain needs glucose to function and I now believe that it is an...
  17. Mithriel

    Complex Regional Pain Syndrome (CRPS), what to do?

    After damaging his shoulder in a fall down the stairs a relative has all the signs of CRPS. every now and then with no apparent reason his shoulder hurts, his hand swells up (a lot!) and turns blue. If anything looks physical that does. The paper by Stone was just rubbish. It made no sense My...
  18. Mithriel

    Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome, 2019, Omdal et al

    And the underlying irony of it all is that fatigue was not a required symptom for ME. I never experienced fatigue and only have a little now after 50 years. I feel fine until I suddenly stop - fatiguability. One day I began to experience fatigue but it turned out to be diabetes. It was different...
  19. Mithriel

    Inhibition of Upf2-Dependent Nonsense-Mediated Decay Leads to Behavioral and Neurophysiological Abnormalities by Activating the Immune Response

    I have family members with autism who are doing quite well to very well but also ones who have a miserable constrained life. A treatment that helps even a little could make a massive difference just like one for ME.
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