Search results

Bardsen's study was published in 2016: Heat shock proteins and chronic fatigue in primary Sjögren’s syndrome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804286/ Notably, Yves Jammes has found lower levels of certain HSPs post-exercise in CFS patients in multiple studies...

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 https://www.nature.com/articles/s41590-020-0782-6 Notably: This contradicts the suggestion by Mateus et al. and Grifoni, A. et al. who suggested there was partial T-cell...

Indeed, Gregory Dore's lack of understanding of the "stigma" of longcovid is notable, given that he is a colleague of Andrew Lloyd at UNSW (and regular coauthor).

Starting at 4 hours per day, increasing by 10% every two weeks, and in a year they'll be doing an impressive 48 hours of high energy activity per day! ;) Seriously though, an increase of 20% per week means reaching the 8 hour target in 4 weeks. An increase of 10% per fortnight means reaching...

It does not cease to surprise me how some people keep trying every sort of rationalisation they can think of, to believe that COVID19 is less devastating than official numbers report. The same sort of people on Twitter deny that longcovid is severely disabling, or insist it is simply due to...

No direct relevance to ME in my opinion. The hypothesis isn't really that "new", I remember it being proposed on Twitter back in March and hypotheses published in April and May: https://www.bmj.com/content/368/bmj.m810/rr-35 (March comment) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267506/...

SARS-2 can certainly cause serious heart problems in (somewhat) rare cases, but this does not apply to most COVID19 cases...

No. This was coauthored by Audrey Stone, at the University of Texas at Austin. You're thinking of Jon Stone at the University of Edinburgh.

The Goal of this study was to test the "perception-filter model" of medically unexplained symptoms (MUS) in "persistent somatic symptom disorder" (SSD) So while participants reporting a higher level of symptoms did have higher heart rates and lower heart rate variation, this was not due to...

This is a useful introduction to the autonomic facets of exercise, but there is of course more going on with regards to the neurology, muscle physiology and biochemistry resulting from exercise. A key point however is the autonomic responses are reactive and lag behind the increase in central...

I'm not convinced that we'll ever have any sort of clinical clarity, given that people use such words to describe very different things, however I see the objective outcomes as augmenting the descriptions of experiences by patients. This is an interesting point. The differing conceptions of...

This wouldn't be the first self-declared expert to have failed to listen and understand the views of patients and to go on and mischaracterise patient views in scholarly literature. I note this (English) review by Sten Helmfrid and Johan Edsberg...

Open-label...

The key is to use a different approach in development, the unique step being to prune the list of questions on the basis of FACE VALIDITY by patients. Too often the questions are selected by researchers, not patients.

From that paper: Minute ventilation and heart rate decreased during (pre-conditioned) placebo, so basically, the individual expected more oxygen and hypoventilation was the result. But so what? This is a conditioned behaviour, not a physiological response. The author of the editorial also...

I disagree, PLOS One is a reputable journal. But it seems the peer-reviewers for this one happened to be a bit to like-minded.

It doesn't say what the ratio is, unfortunately. Given that this is a pre-print, some things can be updated if we are able to notify the authors!

It is curious that a similar number of new cases per million is leading to Aussies freaking out about a "second wave", but a similar number in Sweden is considered "pandemic is over"!?!

"weak immune activation" leads to a lack of antibodies. I don't think this is the problem at all. I agree the key is to be given to patients early. Given late and it will just contribute to the vascular/clotting problems seen in severe patients.

It is certainly confusing. I had to double check Table 1 to confirm that you were right! The error bars don't suggest statistical significance. The lack of significance is likely due to lack of sample-size and within-group variability.