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I can try to explain a bit more why I don't think there is any reason to think this is an undervalued breakthrough and that historical analogies are invalid but just one thing for now Long Covid goes on for months and for some more than a year already. ME much longer. If there are micro clots...

I do not see any reason to think that. Why should they not do a tight double-blinded randomised controlled trial as Fluge and Mella did? Why would they have to break early? The question I would like the answer to is why the scientific community as a whole is showing no interest. What if every...

One can hope, but I suspect the patient community had made that clear by 2005. I distrust the way bureaucracies go about 'patient inclusion'. NICE got it right but there is a suggestion that in the US things have slipped back into the hands of the rehab people.

I agree again. To me this is parasitic do-gooding sociology masquerading as being helpful. This bit: participating in an illness has the potential to enable a new identity to emerge, a sick identity which can legitimise an illness experience and engender the acceptance and support of others...

The site says intramuscular.

I think the protein antigen in the vaccine is made using genetically modified plants like potatoes.

But as @Arvo says, it might be misinforming the uninformed. It seems to focus on the division between ME and CFS and brings in a lot of pseudophilosophical and sociological jargon.

Bound to be an advert from a Jungian psychoanalyst sooner or later.

We bin there done that?

I think the micro clots came from cell free plasma fractions - i.e. no cells in them. Squishiness would not encourage clotting. The squishier they are the faster the blood can move and the less likely it is to clot - since stasis is one of the things that encourages clotting. I thought that...

This seems to be saying that you see changes on MRI if you just subject normal healthy people to a bit of a psychological game of 'stress'. Presumably, the level of stress involved is minimal. If anything it might be quite fun, like playing charades. So these sorts of MRI changes probably tell...

PP is B3

vitamin H is a silly name for biotin (B7)

Indeed, I was not suggesting that any reply to RCPCH would focus on any particular statement. I have no particular thoughts about what one might write to them but it might be something like: Would the RCPCH agree that the briefing document fails to take into account the broad message of the...

I wouldn't take too much note of that. A single monoclonal antibody raised against an antigen may by chance cross react with just about anything. This isa well recognised problem in immunohistochemistry. We once did a study using monoclonals raised against TNFalpha. We got all sorts of weird...

I agree with Barry that you absolutely can fault them. Selective use of specific language is not necessarily legitimate. 'Pull the red lever' might be an exact quote from a notice that says 'In case of fire pull the red lever'. Yes, I think this bit has no business in the guideline. It is...

Did they consider that a history of exposure to violence might have contributed to a doctor saying 'oh, of course, must be fibro - I will explain it all to them (and put the diagnosis on the database)'.

The problem is that 'saying what it actually says' is a weasel. Philosophers write whole books about 'what it actually says' but miss the point that what text means is always critically dependent on all sorts of other context. It comes under the discipline of pragmatics and there is no end to...

It is an interesting phenomenon and something I am going to spend some time on in my book. The simplest answer seems to be that a lot of the bad science critics are people who find themselves in science but do not really like science - and particularly do not like high tech Pharma science. They...

I think it is wrong because it is taken out of the context of specifically limiting it to people who are wanting to do more and feel able to. I absolutely agree with Trish that it would have been better not to have any of this in the guideline but there were (some) reasons for accepting it was a...