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  1. Andy

    Article: Science: Is exercise actually good for the brain?

    "There are plenty of reasons to get off your duff and exercise—but is improving your brain one of them? The U.S. Centers for Disease Control and Prevention touts exercise as a way to “boost brain health,” while the World Health Organization suggests that about 2 hours of moderate activity or 75...
  2. Andy

    Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection 2023 Ahuja et al

    Why Some People Get Sick More Often "Everyone gets sick. Despite all the vegetables we eat or vitamins we gulp down, sooner or later pathogens such as viruses and harmful bacteria infiltrate our bodies, and we need to take a time-out. We sit back and let our immune system do its job. But when...
  3. Andy

    Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection 2023 Ahuja et al

    Abstract Some people remain healthier throughout life than others but the underlying reasons are poorly understood. Here we hypothesize this advantage is attributable in part to optimal immune resilience (IR), defined as the capacity to preserve and/or rapidly restore immune functions that...
  4. Andy

    Guide: Involving People with ME and Other Energy Limiting Conditions, by the World ME Alliance

    I've posted before reading this, so have no opinion on it yet, although at the least I think the topic is an important one.
  5. Andy

    Guide: Involving People with ME and Other Energy Limiting Conditions, by the World ME Alliance

    The World ME Alliance, a global coalition of organisations advocating for those affected by Myalgic Encephalomyelitis (ME), is proud to announce the release of a new guide. This comprehensive resource, titled “Involving People with ME and Other Energy Limiting Conditions,” aims to promote...
  6. Andy

    UK: New £14 million investment targets rare diseases

    A new platform bringing together UK strengths in rare diseases research to improve diagnosis and treatment through better understanding of the disease. The UK Rare Disease Research Platform has been established with a £14 million investment over five years by the Medical Research Council (MRC)...
  7. Andy

    The neuroimaging evidence of brain abnormalities in functional movement disorders, 2021, Sasikumar and Strafella

    So when properly investigated physical abnormalities are found in people diagnosed with a functional condition, and somehow that supports the idea of functional conditions, rather than highlighting how flawed it is?
  8. Andy

    Closed UK: DecodeME updates, was recruitment thread.

    In the UK there is, https://bepartofresearch.nihr.ac.uk/, but awareness of it is low.
  9. Andy

    Typing myalgic encephalomyelitis by infection at onset: A DecodeME study, 2023, Bretherick et al

    Revised version is available, following peer reviewers comments, https://openresearch.nihr.ac.uk/articles/3-20/v2 "Amendments from Version 1 The revised manuscript has benefited greatly from the reviewers’ constructive suggestions. In response, the study’s main aim has been made explicit in...
  10. Andy

    Functional Neurological Disorder (FND) - articles, social media and discussion

    Jon Stone has had an editorial published titled "Functional neurological disorder: Past, present and future", paywalled, https://www.sciencedirect.com/science/article/abs/pii/S0013700623000908, with no abstract available. What is shown is "Acknowledgments This special FND issue of L'Encéphale...
  11. Andy

    Review Mechanisms and Severity of Exercise Intolerance Following COVID-19 and Similar Viral Infections: A Comparative Review 2023 Weldon et al

    What a mess of an article. Just two examples "Post-Infection Fatigue Syndrome (PIFS) As discussed above, there is an acute decrease in strength and endurance immediately following a febrile illness. However, in some patients, symptoms may persist and result in chronic exercise intolerance and...
  12. Andy

    Review Mechanisms and Severity of Exercise Intolerance Following COVID-19 and Similar Viral Infections: A Comparative Review 2023 Weldon et al

    Abstract Approximately 19% of the population is suffering from “Long COVID”, also known as post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC), which often results in exercise intolerance. As COVID infections continue to be common, studying the long-term...
  13. Andy

    Functional Neurological Disorder (FND) - articles, social media and discussion

    Trial By Error: A Letter to Psychological Medicine about Inflated FND Rate Claims "The journal NeuroImage: Clinical, an Elsevier title, recently agreed to correct the false statement that a 2010 study found functional neurological disorder to be the second-most-common diagnosis at outpatient...
  14. Andy

    First major survey of doctors with Long Covid reveals debilitating impact on health, life and work, 2023, BMA media team

    And that is from people who are part of the system. And from the report, "It has been informed by a UK survey of over 600 doctors suffering from the continuing effects of an infection with COVID-19, as well as wider research of the issues. The survey was undertaken by the BMA in partnership...
  15. Andy

    Wearable movement-tracking data identify Parkinson’s disease years before clinical diagnosis 2023 Schalkamp et al

    Parkinson’s disease is a progressive neurodegenerative movement disorder with a long latent phase and currently no disease-modifying treatments. Reliable predictive biomarkers that could transform efforts to develop neuroprotective treatments remain to be identified. Using UK Biobank, we...
  16. Andy

    Letter: The overview on current evidence for the treatment of ME/CFS is based on the principles of scientific assessment 2023 Ludwig et al

    Blog from Brian Hughes. “A science that does not allow opposing opinions abolishes knowledge.” Er, kind of "Colleagues and I have responded to a paper in Der Nervenarzt, the leading German neurology journal, pointing out various reasons why its “overview” of evidence-based approaches to ME/CFS...
  17. Andy

    YourgutPlus+ - a pro- and pre-biotic supplement

    From their FAQ, https://yourgutplus.com/frequenty-asked-questions/ 1. What is a delayed release capsule? The vegetable based capsule which carries the ingredients is designed to resist the acid in the stomach allowing the healthy bacteria to pass into the remaining gut where they are most...
  18. Andy

    The Intriguing Role of Histamine in Exercise Responses, 2017, Luttrell

    One of our oldest threads discusses this, Ranitidine (Zantac) for its IL6 inhibitory properties
  19. Andy

    The Intriguing Role of Histamine in Exercise Responses, 2017, Luttrell

    Not surprising, some people with ME/CFS have reported benefit from them as well.
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