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  1. ME/CFS Science Blog

    Effectiveness of psychosomatic therapy for patients with persistent somatic symptoms: Results from the CORPUS... 2023 Wortman et al

    The description of the treatment is so vague, it is hard to know what exactly it entailed. I wish it was common standard to include the treatment manual or a link to it. It must exist as the paper writes: "The therapists received an intervention manual describing the sessions"
  2. ME/CFS Science Blog

    Effectiveness of psychosomatic therapy for patients with persistent somatic symptoms: Results from the CORPUS... 2023 Wortman et al

    The authors write: "For patients with moderate PSS, psychosomatic therapy seems to be effective compared with patients with severe PSS. This is in agreement with a previous study with an individual, nurse-led CBT-based intervention for patients with PSS [28] that was particularly suitable for...
  3. ME/CFS Science Blog

    Effectiveness of a cognitive behavioural intervention for patients with undifferentiated somatoform disorder - 2019 Sitnikova et al. (CIPRUS trial)

    Seems like another null result that is spinned into something positive. The authors write: "Overall we found statistically significant effects of our intervention, but effect sizes were small (d = 0.22 for RAND-36 PCS, d = 0.33 for role functioning/physical, and d = 0.23 for bodily pain), and...
  4. ME/CFS Science Blog

    Effectiveness of a cognitive behavioural intervention for patients with undifferentiated somatoform disorder - 2019 Sitnikova et al. (CIPRUS trial)

    Published in the Journal of Psychosomatic Research Abstract Objective: To examine the effectiveness of a cognitive behavioural intervention delivered by mental health nurse practitioners (MHNPs) to patients with undifferentiated somatoform disorder (USD), compared to usual care. Methods: We...
  5. ME/CFS Science Blog

    Effectiveness of psychosomatic therapy for patients with persistent somatic symptoms: Results from the CORPUS... 2023 Wortman et al

    I don't interpret it as that the participants weren't properly informed ('lack of clarity about what the trial was aiming to do') or that they think patients were too stupid to understand the materials. It feels more like a criticism that patients weren't willing enough to go along with the...
  6. ME/CFS Science Blog

    Effectiveness of psychosomatic therapy for patients with persistent somatic symptoms: Results from the CORPUS... 2023 Wortman et al

    Yes really misleading. Supplementary material C shows that PSC-2 and PSC-3 showed no statistically significant difference between the group. Makes me think the result was also not significant if the three questions were combined. And if they corrected for multiple comparisons, none of the...
  7. ME/CFS Science Blog

    News from Scandinavia

    Is there a connection to Red labo of De Meirleir in Belgium?
  8. ME/CFS Science Blog

    When Dying Patients Want Unproven Drugs

    Interesting read. I'm not sure though that loosening FDA regulations is in the interest of patients. The article also touches on the questions of patient groups being influenced by drug companies. It points to this article which found that of 104 U.S.-based patient-advocacy organizations with...
  9. ME/CFS Science Blog

    News from Belgium

    Dr. Elke Van Hoof is a psychologist who previously worked with Kenny De Meirleir and published several papers on CFS. She then moved to other things such as burnout and hypersensitivity. In the articles, her team accused her of toxic leadership. She also made some questionable claims about Eye...
  10. ME/CFS Science Blog

    Predicting Myalgic Encephalomyelitis/Chronic Fatigue Syndrome from Early Symptoms of COVID-19 Infection , 2023, Hua et al

    Agree. Direct quote from the article: "Participants were asked to complete two symptom questionnaires, one of which detailed “present” symptoms and the other “recalled” symptoms from the first two weeks after COVID-19 diagnosis, an average of 21.7 weeks prior." It would be interesting data if...
  11. ME/CFS Science Blog

    Thesis An experimental study investigating the link between symptom reporting and heart rate variability in CFS patients, 2023, Dest & Grosemans

    The thesis writes: "The study topics and research questions were determined in collaboration with Msc. Y. Dooms and Dr. Maaike Van Den Houte. Due to the fact that the study was a component of an ongoing research project, we were not involved in decisions about research design or methodology"
  12. ME/CFS Science Blog

    Opinion Pragmatism in the fray: Constructing futures for ‘medically unexplained symptoms’, 2024, Greco

    The link to the article does not work for me but I noticed that the chapter is also uploaded here: (PDF) Pragmatism in the fray: Constructing futures for 'medically unexplained symptoms' | Monica Greco - Academia.edu
  13. ME/CFS Science Blog

    Feeling insecure about romantic relationships

    Certainly no expert here but I think all of these things don't matter that much for love. I suspect you're underestimating yourself. Based on your posts on S4ME you seem intelligent and kind. Lots of people are in this situation and I suspect there is no other answer than just give it a try...
  14. ME/CFS Science Blog

    Mapping microglia and astrocyte activation in vivo using diffusion MRI, 2022, Garcia-Hernandez et al

    An article about this paper: Magnetic resonance imaging shows brain inflammation in vivo for the first time (medicalxpress.com) It sounds interesting. Here's a relevant paragraph: "An innovative strategy developed by the researchers has made possible this important breakthrough, which is...
  15. ME/CFS Science Blog

    Why hasn't neuroscience delivered for psychiatry? - David Kingdon

    Not exactly a recommendation. The authors asks: "isn’t listening to patients perceptions of causation more likely to provide insights rather than looking down a microscope?" The main question - "Why do we not have evidence of biological malfunctioning for severe mental disorders?" - is...
  16. ME/CFS Science Blog

    Why hasn't neuroscience delivered for psychiatry? - David Kingdon

    Abstract Biological research has produced major advances in our understanding of our bodies and, where systems go wrong, is producing remedies to address these, but it has yet to do the same for the mind. This is because no causative biological evidence has been found for the major mental...
  17. ME/CFS Science Blog

    Efficacy of cognitive behavioral therapy targeting severe fatigue following COVID-19: results of a randomized controlled trial 2023, Kuut, Knoop et al

    I think a threshold of 35 has been used before for the CIS questionnaire see for example: The assessment of fatigue: Psychometric qualities and norms for the Checklist individual strength - PubMed (nih.gov)
  18. ME/CFS Science Blog

    No evidence for neuronal damage or astrocytic activation in cerebrospinal fluid of Neuro-COVID-19 patients with long-term persistent headache, 2023

    Yes it seems that there were only 7 patients with persistent postCOVID-19 headache. IMHO it should be required the mention the sample size in the abstract.
  19. ME/CFS Science Blog

    News from The Netherlands

    There was a short update on the ZonMw ME/CFS program. Sjaak de Gouw will be the new chair of the program. https://www.zonmw.nl/nl/nieuws/mecvs-update-nieuwe-commissievoorzitter-nieuwe-richtlijn-mecvs-en-1e-projecten-van-start Copied to The Netherlands - €28.5 million ME/CFS research program -...
  20. ME/CFS Science Blog

    The Netherlands - €28.5 million ME/CFS research program - ZonMW funding awards announced April 2023

    Post copied and reply moved from the news from the Netherlands thread. There was a short update on the ZonMw ME/CFS program. Sjaak de Gouw will be the new chair of the program. https://www.zonmw.nl/nl/nieuws/mecvs-update-nieuwe-commissievoorzitter-nieuwe-richtlijn-mecvs-en-1e-projecten-van-start
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