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  1. Andy

    International: Science for ME social media posts

    Published papers thread for w/c 8th Jan. Facebook: https://www.facebook.com/sci4me/posts/pfbid02wKEdtNhqLCtdQ89WdwdZQegnXr3xoUo7KuxcZY7LPmEyPqUPobxkVuwVtmCM5sP7l Mastodon: https://med-mastodon.com/@s4me/111759505741210749
  2. Andy

    Assessing Functional Capacity in [ME/CFS]: A Patient Informed Questionnaire [FUNCAP], 2024, Sommerfelt et al

    A few comments, all with the proviso that I understand creating a good questionnaire is challenging. Given that the questionnaire says, "Items described include necessary activities to perform them. Example: "Going to a shop for groceries" includes getting dressed and as necessary travelling."...
  3. Andy

    Examination of Single Nucleotide Polymorphisms in Acetylcholine Receptors in Chronic Fatigue Syndrome Patients 2015 Marshall-Gradisnik et al

    Abstract Objective Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a disorder characterized by debilitating fatigue accompanied by pain and impairments in memory, cognition, and concentration. Acetylcholine (ACh) has a plethora of roles in neuronal and neuromuscular transmission...
  4. Andy

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    For what it is worth. Some people report benefit from Mestinon. Mestinon is pyridostigmine bromide. From Wikipedia, "Pyridostigmine bromide has been FDA approved for military use during combat situations as an agent to be given prior to exposure to the nerve agent Soman in order to increase...
  5. Andy

    Acetylcholine mediated vasodilatation in the microcirculation of patients with CFS 2004 Spence, Khan et al

    Abstract The aetiology of chronic fatigue syndrome (CFS) remains controversial and a number of hypotheses have been put forward to explain it. Research into the condition is hindered by the considerable heterogeneity seen across patients but several reports have highlighted disturbances to...
  6. Andy

    Prolonged acetylcholine-induced vasodilatation in the peripheral microcirculation of patients with CFS 2003 Khan, Spence et al

    Summary Although the aetiology of chronic fatigue syndrome (CFS) is unknown, there have been a number of reports of blood flow abnormalities within the cerebral circulation and systemic blood pressure defects manifesting as orthostatic intolerance. Neither of these phenomena has been explained...
  7. Andy

    Review nature reviews cardiology: Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health care burden, Fedorowski et al, 2024

    Given that 2 years ago Mango reported, about a different paper, that he really shouldn't be now claiming ignorance around the issue of GET and PACE.
  8. Andy

    International: Science for ME social media posts

    News in Brief posts for w/c 8th Jan. Facebook: https://www.facebook.com/sci4me/posts/pfbid02tdW38uB1o67Rwand4LLAimUcTpZ1LipDjReuBdxPCmfz4KvdbQ53wMme3TX4jVSKl Mastodon: https://med-mastodon.com/@s4me/111754020268199671
  9. Andy

    Petition: S4ME 2023 - Cochrane: Withdraw the harmful 2019 Exercise therapy for CFS review

    9,863 signatures at time of posting. https://www.change.org/p/cochrane-withdraw-the-harmful-2019-exercise-therapy-for-cfs-review
  10. Andy

    Incongruence in FND: time for retirement 2024 Stone

    Unless his future actions and words prove otherwise, I assume that this is just more positioning to attempt to maintain FND concepts as relevant, rather than accepting that it is a waiting room for issues that currently science either can't explain or hasn't properly investigated. Even him...
  11. Andy

    Incongruence in FND: time for retirement 2024 Stone

    [Don't get your hopes up, this is not Stone's announcement of his retirement] The diagnosis of functional neurological disorder (FND) has rested traditionally on two key features: inconsistency and incongruency. Inconsistency usually refers to inconsistency between movement, sensory or...
  12. Andy

    Functional Neurological Disorder (FND) - articles, social media and discussion

    Posting this here as no abstract or working link to journal is available at time of posting. Functional neurological disorder: defying dualism, 2024, Jon Stone, Ingrid Hoeritzauer, Laura McWhirter and Alan Carson Pubmed, https://pubmed.ncbi.nlm.nih.gov/38214630/
  13. Andy

    Preprint Post-COVID cognitive deficits at 1 year are global and associated w/elevated brain injury markers and grey matter vol reduction:... 2024 Michael et al

    Trial By Error: Study Finds “Elevated Brain Injury Markers and Reduced Grey Matter Volume” a Year After Hospitalization for COVID-19 A British study of neurological sequelae in patients many months after hospitalization for COVID-19 has found that “post acute cognitive deficits…were associated...
  14. Andy

    First trans-diagnostic experiences with novel micro-choice based group rehabilitation for low back pain, long COVID, type 2 DM, 2024, Kvale+

    Apparently not, but very similar. See A safe and effective micro‑choice based rehabilitation for patients with long COVID: results from a quasi‑experimental study 2023, Frisk et al
  15. Andy

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    Neither the ICC, CCC or IOM criteria for ME/CFS require PEM to be delayed. While I am fully in agreement that PEM should be defined as something that occurs after an unusually long delay, currently it isn't, so it seems to me that the authors are justified in calling what they are studying PEM.
  16. Andy

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    From the paper, "The most reported symptoms of long COVID include limited exercise tolerance and post-exertional malaise, representing the worsening of symptoms after mental or physical exertion" and "In this study, we systematically induced post-exertional malaise in a cohort of 25...
  17. Andy

    Muscle abnormalities worsen after post-exertional malaise in long COVID, 2023/4, Wüst, van Vugt, Appelman et al

    Does the paper claim to account for PEM caused by mental exertion?
  18. Andy

    Effects of a residential psychoeducational parenting program on maternal anxiety and fatigue symptoms 2024 Tran et al

    ABSTRACT Aims To evaluate the effects of a 5-day residential psychoeducational program on maternal anxiety and fatigue symptoms among women admitted with their unsettled infants and determine the psychological, social and demographic characteristics which are associated with the effect sizes...
  19. Andy

    Review [ME/CFS] as a complication of COVID-19 post-acute syndrome in adults. Bibliographic Review 2023 Carrillo Uguña and Orellana Romero

    Abstract According to the latest report from the World Health Organization and the Pan American Health Organization, CO-VID-19 currently presents a morbidity of 29.6 % and constituted 43.6 % of deaths worldwide. Although mortality rates have decreased considerably, many cases of patients with...
  20. Andy

    Judy Mikovits

    It's more that following the XMRV events, Mikovits became more and more extreme in her stated views until, come the pandemic, she ended up being a full-on anti-vaccine, "it's all a govt plot and Fauci is to blame" conspiracist, who was featured in the Plandemic film.
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