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@Sean provided a working link to the document in this post from 2019. It seems like it was removed from the original link quite soon after Bruce Levin gave his presentation on the subject.

Yes, you could well be right about this. I have no institutional affiliation and my registration is currently pending, so we'll see if they allow me, a layperson, access to the datasets they have.

Have you seen the mapMECFS project, @mariovitali? It describes itself as "an interactive data portal providing access to research results across many biological disciplines from studies that are focused on advancing our understanding of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome...

In the paper they write: "Both the autonomic and central motor dysfunction result in a reduction in physical activity. With time, the reduction in physical activity leads to muscular and cardiovascular deconditioning, and functional disability." It's the trailing "and functional disability" in...

Isn't this the key rebuttal? As in, if the effort preference of a good chunk of ME patients is no different to the healthies (and in many cases exceeds them), then it can't be a central, defining feature of ME. And if Walitt wants to argue that low effort preference eventually leads to...

There's one tiny typo in an otherwise fantastic letter @ME/CFS Skeptic, "Walit" should be "Walitt".

I looked and couldn't find any code for the EEfRT analysis. It would be great if someone could find it. It does say under "Statistical analysis of effort expenditure for rewards task" that "All GEE models were implemented in SAS 9.4" so maybe there isn't any R code for this section?

The PIs write in the main paper that "The primary measure of the EEfRT task is Proportion of Hard Task Choices (effort preference)." Do they give a justification for why this is the "primary measure"? Is there a validated precedent in the literature for using this particular ratio? It's just...

> Persons with PI-ME/CFS were more likely to choose the easy task over the hard task compared to the healthy volunteers. But if you can't do the hard task then there is no choice. It's the wrong verb. It would be more accurate if they had said something like "Persons with PI-ME/CFS were less...

One way to think about it is that it's almost as though HVF was playing by a different set of rules. There's an implicit rule, I think, that would go something like "if you can complete a task you should complete a task". There's no way to tell for sure that players are obeying this rule but I...

Curiouser and curiouser. Before the clock started ticking each participant (I think) got four trial runs (they're marked as trials -4, -3, -2 and -1 in the data). In HV F's trial runs he scored 30 / 30, 30 / 30, 98 / 98 and 98 / 98 (a perfect run), but when the experiment proper started he...

Healthy volunteer F was indeed a highly atypical button presser(!), and I can see why the investigators treated his data with caution. If you subtract the number of times he pressed a button from the required number of presses for a given trial, you get this list: [20, 21, 2, 0, 19, 1, 2, 4...

I've been trying to work out what the optimal play is given the rules of the game. I think it would be something like this: since your actual prize is two amounts chosen probabilistically from the basket of all the tasks you complete successfully, the best strategy is to i) flunk all the...

From Worth the ‘EEfRT’? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia Treadway et al: ... For easy-task trials, subjects were eligible to win the same amount, $1.00, on each trial if they successfully completed the task. For hard-task choices...

It's never explicitly stated, but if you look in the supplementary data on page 9 of the file titled 41467_2024_45107_MOESM1_ESM.pdf there's a diagram which shows this (and I think it's more clearly set out in some of Treadway's work.) I also struggled to understand the task for the same...

Isn't it because the reward value for the easy task is always lower than the reward value for the hard task (with the probability of winning being the same)? For an easy task the reward was always $1 whereas for the hard tasks the reward was one of [1.24, 1.42, 1.6, 1.78, 1.96, 2.14, 2.32, 2.5...

Here's a linky to the preprint fulltext on bioRxiv: Remembering immunity: Neuronal ensembles in the insular cortex encode and retrieve specific immune responses.

Sorry @Lucibee, I can't do any better than Michiel and others further back in the thread. The only documents I can access are the Patient PR Manual and the Physiological Explanation Of Symptoms For CFS Patients. The Internet Archive has indexed the others but not saved them properly. Very...

I've also had this problem with Twitter and Firefox but it goes away if I open the link in a private window -- right click "Open Link In New Private Window".

I think there are two PRINCE trials? PRINCE primary (as in primary care) and the one above, PRINCE secondary.