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That’s a shame. Hopefully we’ll here more later and video/audio or summaries will be available for those unable to follow live. Although the main thing here is that some of the right people seem to be getting together and sharing interesting work and discussions.

Looks like they’re sending out emails (including a pdf) to people previously contributed feedback

Thanks for the live-blogging @Jonathan Edwards we’ll make an influencer of you in no time ;) *liked and subscribed*

This has also been covered by @forestglip in the writeup (Referring to the findings from Sharpe et al.1996)

Do people think it could feel or be experienced very differently although be a similar underlying mechanism then? Or that combination of factors I mentioned before to? What some of us seem to be describing is an outsized bodily response to what some may characterise as a normal infection...

Which raises the question, what sort of group/subgroup sizes would we need to be able to distinguish this?

Yeah that’s why I’m so interested in if there’s a correlation with severity and response. I want to see nice graphs of both dose and severity responses. That information could be really useful. Good point about there potentially being other, maybe even better ways of determining that if we can...

I think @Utsikt is just suggesting start low and ramp up as opposed to start high and ramp down? Which gets you to the same place, an understanding of dose response and minimum effective dose.

@Felis Catus describes something similar I think. I’ll try and write something more over the next few days and send it to you.

Thanks @Jonathan Edwards that’s really useful. Even talking about it here with something comparatively innocuous feels like quite a responsibility. I don’t envy anyone having to weigh some of these factors up. I’m really torn on this. On the one hand I want clear, indisputable evidence. I want...

The infection that triggered everything for me was kidney stones, a kidney infection that wasn’t handled well by people and got out of hand and sepsis that was thankfully handled well. And I was so out of it in that that I couldn’t stand and was being wheeled around. And while recovering wanted...

What I began to experience with ME/CFS in terms of OI was unlike anything I’ve experienced before with any sort of illness or infection apart from perhaps myocarditis. I used feel tired and have a desire to lie down with illness/infections but not anything close to the level of discomfort and...

Ultimately in Asimov’s writing this wasn’t solved until sometime after resource allocation was taken over by the robots… Humans have too many problems of self interest and so on. It may not be the solution. Maybe there isn’t one. But perhaps on the path to wherever we’re going we will need more...

We’ve discussed the idea that AI will lead to a crisis for the discipline and careers in mathematics. That the value comes from understanding not from the solutions. What happens when these longstanding and interesting problems are all solved? But could there be a Jevons paradox of sorts. We...

As someone who has actually had to make these decisions do you have any thoughts on what the approach should be here? Is there any informed approach we can base this decision on? Is it a bit of an educated guess? Or is it really just a case of doing a well designed experiment to find out?

Just looking at the bnf pages and it seems lower is commonly used. I wonder what rationale the single doses for these studies were based upon? Common safe daily dosages in use at the time? Were there other reasons? The mention of CYP3A4 inhibitors is interesting too. Could there be something...

Did I say this would fix everything? I’m desperate and trying to find answers, looking for solutions. This reply hurts so I’m going to leave the discussion.

Okay. So what’s the route forward? There’s always risks that something won’t work but I’ve never seen any meaningful change occur unless someone is given or takes responsibility. Then there are motivations to find ways to make it happen. I think it’s really important that we do something. If...

Yes I understand. I deliberately didn’t make my comment as a reply as it was a chain of thought partly inspired by your post rather than meant as a response to you. I should have made that clearer. People are complex! The politics of the NHS certainly is. The only route forward I see is making...

I worry when the word complexity is used. It’s like when people refer to our condition as complex in papers. It’s too often used to make things sound more difficult than they are. It’s used to make it sound as if it would be hard to make our lives better. Or at least stop making them worse. To...