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  1. hotblack
    Post

    UK House of Lords/ House of Commons Questions

    I’d say they’re not a waste of time, but we should also be realistic in what they can achieve and that it varies a great deal between MPs. The...
    Post by: hotblack, Today at 12:48 PM in forum: General ME/CFS news
  2. hotblack
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    For one of the other possible treatments mentioned (anti CD52, Alemtuzumab) there was this overview of use in MS...
    Post by: hotblack, Today at 12:35 PM in forum: ME/CFS research
  3. hotblack
    Post

    What advances in Covid vaccines are on the horizon?

    I’m aware of work on nasal vaccines, there was some hope they’d help reduce transmission. And I’d hope those of us unable to use current covid...
    Post by: hotblack, Today at 11:59 AM in forum: Epidemics (including Covid-19, not Long Covid)
  4. hotblack
    Post

    ME/CFS as a biological information processing problem

    (Edit, I probably posted these two in the wrong order, oh well, a disadvantage of drafting thoughts in notes over time, but the suspect analogy...
    Post by: hotblack, Today at 11:30 AM in forum: General ME/CFS discussion
  5. hotblack
    Post

    ME/CFS as a biological information processing problem

    Someone else mentioned FcγRI can be expressed on neuronal and endothelial cells. Given discussion about problems there, this seems potentially...
    Post by: hotblack, Today at 11:18 AM in forum: General ME/CFS discussion
  6. hotblack
    Post

    Preprint Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights, 2025, Hoel, Fluge, Mella+

    That’s what I was wondering, cause or effect. Useful to know it could be either. I guess the only way we’ll know for sure is from genetic studies?
    Post by: hotblack, Today at 9:17 AM in forum: ME/CFS research
  7. hotblack
    Post

    Preprint Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights, 2025, Hoel, Fluge, Mella+

    So there could be an MCTS1 variation that rather than impairing functionality here enhances it? Another one of the various contributory factors?
    Post by: hotblack, Today at 8:35 AM in forum: ME/CFS research
  8. hotblack
    Post

    Preprint Charting the Circulating Proteome in ME/CFS: Cross System Profiling and Mechanistic insights, 2025, Hoel, Fluge, Mella+

    And here’s links to the genecards (edit: put in a spoiler tag to not clog up the discussion) [SPOILER]
    Post by: hotblack, Today at 7:03 AM in forum: ME/CFS research
  9. hotblack
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    I’ve missed if this had has come up in discussion, it’s not referenced in the paper but I came across it in some searches ME/CFS patients exhibit...
    Post by: hotblack, Yesterday at 8:38 PM in forum: ME/CFS research
  10. hotblack
    Post

    Cytokine signature associated with disease severity in chronic fatigue syndrome patients, 2017, Montoya et al

    Is it worth tagging this thread with IFN-γ or interferon gamma to help in any searches given we’re now all very interested in it? Although there’s...
    Post by: hotblack, Yesterday at 8:14 PM in forum: ME/CFS research
  11. hotblack
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    And this is another reason I don’t think we should consider how some may interpret words or phrases used too much. Those people who are set in...
    Post by: hotblack, Yesterday at 5:11 PM in forum: ME/CFS research
  12. hotblack
    Post

    United Kingdom: Action for ME (AfME) news

    This Friday we have the webinar with updates from Audrey Ryback and the PrecisionLife team, AfMe appear to be accepting questions in advance, I...
    Post by: hotblack, Yesterday at 4:46 PM in forum: News from organisations
  13. hotblack
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    At the other end of the scale I did have an amusing (well, for me) thought. What if we do find a complete cure? Many/most of us would then...
    Post by: hotblack, Yesterday at 10:09 AM in forum: ME/CFS research
  14. hotblack
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    On reversal of any neural plasticity changes once the feedback loop is stopped. I feel confident this could be possible, just a feeling from my...
    Post by: hotblack, Yesterday at 10:04 AM in forum: ME/CFS research
  15. hotblack
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    Fair enough. You know best what your aims are and the ways of working within that world and community. Glad you can discuss things more...
    Post by: hotblack, Yesterday at 10:00 AM in forum: ME/CFS research
  16. hotblack
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    I wonder if there is a way of emphasising this in the paper? I’m not sure how clear this subtlety will be to people who haven’t had the benefit of...
    Post by: hotblack, Yesterday at 9:25 AM in forum: ME/CFS research
  17. hotblack
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    I understand people’s concerns with some terms due to misuse by and connotations with things people who have misused them have said or done. At...
    Post by: hotblack, Friday at 9:01 PM in forum: ME/CFS research
  18. hotblack
    Post

    Forum software update - Forum unavailable weekend 7th to 8th June

    Thanks to everyone involved and good luck with the update. May the SQL gods be kind to you and hope you encounter no PHP gremlins on your travels.
    Post by: hotblack, Friday at 7:05 PM in forum: General ME/CFS news
  19. hotblack
    Post

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    In case anyone newer to the thread missed this, audio versions of the paper are available to listen to here, now with a few fixes and a higher...
    Post by: hotblack, Friday at 5:04 PM in forum: ME/CFS research
  20. hotblack
    Post

    Was there a gap between trigger and onset of your ME/CFS?

    For a while I’ve been wondering about running a different poll, but I’m not sure how to word it. Because I could accept any of these explanations...
    Post by: hotblack, Friday at 4:43 PM in forum: Epidemiology (incidence, prevalence, prognosis)
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