Search results

Thanks @ScoutB that’s really useful. DecodeME Locuszoom for DRD2 which I guess you could say maybe shows a little hump in the area but nothing significant. And not even a blip on DRD1, 3 or 4.

Thanks for letting us know @Andy and nice suggestion @Yann04 :)

Great, thank you so much!

Haven’t read through all this yet but it seems interesting. Some initial questions/thoughts. What would this mean for other drugs interacting with 5-HT 1A serotonin receptors? There seems to be a lot. And many seem prescribed things like SSRIs or other antidepressants, with mixed results. Even...

Thanks for explaining @mariovitali an interesting approach! If you’ve written more on this anywhere please do share any links. On the topic of this thread IMHO the solution in the healthcare industry is for those in it to provide better support. Then fewer people will turn to unsuitable...

No significant signs on LocusZoom PRL PRLR HTR1A

Thread on that paper here btw https://s4me.info/threads/transfer-of-igg-from-long-covid-patients-induces-symptomology-in-mice-2026-chen-et-al.38759/ Others can probably etter chime in on what studies have haven’t been done better but I don’t think there’s has. And there’s few studies in and out...

A different take on the immune system reaction. Also see this write up in Arstechnica When they’re being eaten, bean plants release chemicals that draw in parasitic wasps.

A plant immune receptor mediates tritrophic interactions by linking caterpillar detection to predator recruitment Abstract Plants deploy direct and indirect defenses in response to insect herbivory. The specific antiherbivore responses involve cell surface immune receptors that recognize...

It’s probably difficult as I’m not sure its home vs a place like this that is the discriminating factor, but the approach, attitude of carers and environment provided. Not sure how you can control for that. Well put @Utsikt

Adding this from another thread. It’s a YouTube channel from the guy who was involved in discovering the vault, a part of the cell I haven’t seen discussed and that we don’t know what it does! I’ve been listening to his videos today and they cover a lot more about cell biology, nanotechnology...

We need something like it. Proper understanding care based upon needs rather than ides about rehab or whatever. Just supporting people to live stably the best they can and not get worse. And then ofc more assisted living like places for those who are less severely affected. I dream of a world...

That’s interesting. So maybe one reason there was none with ME/CFS is precisely because it can be triggered by so many different things? Disparate triggers converging on something downstream? Whereas with LC there is one common trigger?

Good luck @Trish I’m using an agency atm for a couple of hours a week, lovely bloke, taken time to get used to and still can be overwhelming when I’m bad (ended up just crying with him yesterday, he was great though), but he helps bring things up to me etc, not great with cooking but can do...

May not be a great fit as they talk about neuronal injury and excitotoxicity in neurodegenerative conditions, which isn’t quite what we’re looking for, but some if the ideas and mechanisms may be useful.

Also see Glutamate Transporter EAAT2: A New Target For The Treatment Of Neurodegenerative Diseases, 2012, Lin et al Abstract Glutamate is the primary excitatory amino acid neurotransmitter in the CNS. The concentration of glutamate in the synaptic cleft is tightly controlled by interplay...

Seems potentially interesting, found while looking around astrocytes and glutamine. Also see this thread on glutamate and fatigue

Riluzole elevates GLT-1 activity and levels in striatal astrocytes Carbone, Marica; Duty, Susan; Rattray, Marcus Abstract Drugs which upregulate astrocyte glutamate transport may be useful neuroprotective compounds by preventing excitotoxicity. We set up a new system to identify potential...

Bumping this old thread as it has some interesting things on glutamate and fatigue and links with MCH neurons. Found while looking things related to astrocyte glutamate transport and coming across Riluzole.

Things I have been thinking. Do we think there are changes in the neurotransmitters themselves or changes in how they are processed? A lot of things seem to point to post synaptic so I guess receptors? But are we talking changes to the receptors or to some other part of the machinery of...