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Yes, so I did gene set enrichment analysis on the ranked list of genes from the Zhang study, meaning I took all ~17,000 genes, sorted by the attention score they got in the study, and tested which gene sets were over-represented among the highly ranked genes. In other words, going through...

Yes, if it was education-related confounding, I don't think it'd just be something like they learned more in school or had better teachers or something like that. I'd think it'd be something like people existing in a different school year with a whole different group of peers and possibly life...

Note that the regression they did weighed birthweeks closer to the cutoff point more heavily. That's the grey shading of the dots in the figures above. It looks like past about [edit: two years] on either side, there was very little weight given to the data points. They did this because the...

Posts about different papers have been split off to their own threads: The recombinant shingles vaccine is associated with lower risk of dementia, 2024, Dercon et al Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections, 2025...

Reply: Methodological Issues in Taquet et al.‘s analysis preclude any conclusions regarding AS01 adjuvant’s specific role in dementia prevention Williams, S. Elizabeth; Luisi, Kate; Liang, Caihua; Cane, Alejandro; Begier, Elizabeth Abstract Taquet et al. evaluated the impact of...

I skimmed. Some of the description of the symptoms of ME/CFS seems all right, though kind of generic sounding so possibly AI. It culminates in advertising a treatment that they sell:

It is, but it looks like you need an account to read it. Not a huge barrier, but not everyone will want to do that. "Create an account to redeem your FREE article"

Could you comment or add a quote on what this is about? The article is behind a paywall.

Seems reasonable to me. Patients already go on ClinicalTrials.gov, where they'd see all these studies. This just filters it to relevant studies for their condition to make it easier. Is this kind of study even more harmful to a patient than something like a 2-day CPET study? Should those also...

Some posts have been moved to the thread for the Visible app: Monitoring app - Visible - a platform "designed for any invisible illness that benefits from resting and pacing - including ME/CFS & Long Covid."

Response to the above: There is currently no evidence that long-COVID-19 leads to neurodegenerative diseases such as SDAT, amyotrophic lateral sclerosis, or Parkinson’s disease Finsterer, Josef No abstract, snippets: Web | DOI | Brain Circulation | December 2025

From long COVID to neurodegeneration Carpio-Orantes, Luis Del No abstract. Snippets: Web | DOI | PMC | PDF | Brain Circulation | Commentary | Jan-Mar 2025

Immune transcriptomic changes in Australian Gulf War veterans Eaton-Fitch, Natalie; Sasso, Etianne Martini; Marshall-Gradisnik, Sonya [Line breaks added] Background Gulf War Illness (GWI) is a chronic multisystemic illness found in one-third of Gulf War Veterans. The aetiology of GWI is...

Risk Factors for Severe Post-COVID Condition in Children, Adolescents, and Young Adults [Line breaks added] Background Post-COVID condition (PCC) in children and young people (PCCcyp) remains a significant health burden. Early identification of patients at risk for severe disease, including...

They also used a 19 year old study for prevalence. I assume because prevalence studies have moved on to newer criteria since then. I don't see any mentions of post-exertional malaise. I mean if they want to study a disease defined by those criteria, I guess CFS is the name of it. But it...

I appreciate your determination to pursue this lead, nataliezzz. I unfortunately don't have the bandwidth to really engage with the topic. Just from the abstract and a quick skim, ~20% prevalence of FM seems fairly high to me, even given fairly broad criteria, so it seems plausible that...

You did say: So it seems like we can't be sure of the prevalence of FM in asymptomatic OSA based on this study, since people in a study are probably mostly symptomatic.

Note that we have a members only thread for this topic as well: Poisoned Feeling

Feasibility of predicting next-day fatigue levels using heart rate variability and activity-sleep metrics in people with post-COVID fatigue [Line breaks added] Background Post-COVID fatigue (pCF) represents a significant burden for many individuals following SARS-CoV-2 infection. The...

I didn't put this in the ME/CFS forum because their definition of CFS is just high fatigue: