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Interesting commentary about the field of chemical exposomics: Will Chemical Exposomics Be Ready for a Human Exposome Project? Martin, Jonathan W. Web | DOI | PDF | Environmental Science & Technology | Open Access | 2026 Snippets:

It's using an older assembly/coordinate system called GRCh37. The more recent one that DecodeME uses is called GRCh38. Defining where exactly a SNP is on a chromosome isn't an exact science, so as they learn more, they make updates to the positions. "Liftover" is converting the coordinates to a...

Here are the top 20 most significant traits associated with the lead DecodeME SNP at the CA10 locus (rs34626694) on GWAS Atlas. Reaction time is also fairly significant.

Jonathan found another study mentioning this gene: I haven't tried downloading it to compare directly, but here is the paper's plot of the locus: Here is that shoulder/neck pain lead variant (rs9889282) highlighted in the DecodeME locus: So I'm not sure, but maybe the variant is shared with...

I searched the top SNP (rs34626694) at the CA10 locus with the GWAS Atlas PheWAS search. The trait most significantly associated with this SNP is "Ease of getting up in the morning", which would make sense as being related to ME/CFS. This trait was tested in the following study, and was based...

Some posts about the FUNCAP survey have been moved to: Assessing Functional Capacity in [ME/CFS]: A Patient Informed Questionnaire [FUNCAP], 2024, Sommerfelt et al

Titles of sections: 1. Introduction 2. Acute COVID-19 and the emergence of persistent illness 3. Patient narratives and early recognition 4. Patient support groups and digital communities 5. Naming Long COVID 6. Medical gaslighting in the context of Long COVID 7. Patient voices in treatment and...

“Long COVID”: The First Illness in History Named by Patients Mari Shiozaki Abstract The COVID‑19 pandemic created a large population of individuals who continued to experience debilitating symptoms long after the acute infection had resolved. This chapter examines the emergence of Long COVID...

Pathogen Effector Convergence Theory (PECT): A Protocol to Create a Unifying Framework for Post-Acute Infection Syndromes (PAISs) Jain, Nita Abstract Post-infectious syndromes (ME/CFS, Long COVID, PTLDS) represent significant global health challenges with overlapping clinical manifestations...

High prevalence of obstructive sleep apnea in patients with Long-COVID. Background Long-COVID (LC) is defined as the persistence of symptoms 12 weeks after the acute COVID infection not explained by any other alternative diagnosis. Its pathophysiology is poorly understood. Obstructive Sleep...

I would say this is still a little inaccurate. DecodeME didn't find differences in genes, they found differences in genetic variants. As far as I can tell, the mapping of these variants to immune or nervous system genes is still very speculative. The other two main findings are the MAGMA...

They saw basically the same pattern in the idiopathic chronic fatigue group, so I think probably not just chance: Maybe just that more viral infections happen in the winter.

From paper:

Sex Differences in Long COVID Prevalence Over One year After the Acute Phase, and Related Risk Factors. The GINA-COVID Cohort Study Background This 1-year cohort study aimed to track long COVID prevalence, identify associated risk factors, and assess its association with hospitalization...

The efficacy of exercise in patients with myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review and meta-analysis Zhao, Liping; Gou, Bo; Zhang, Meng Objective To evaluate the efficacy of exercise training for patients with myalgic encephalomyelitis/chronic fatigue syndrome...

I don't see anything that suggests 23andMe would report a thymine when there is no thymine. And contrary to what DonnellanP just said: That page looks like evidence that they do expect individuals to go through their DNA and look at their alleles.

Based on zero evidence presented by you, despite several requests to understand why you are saying this.

I have continued searching for terms that are highly correlated to search interest for "chronic fatigue syndrome" at the metro level, using the program I used before (with some alterations for finding better related terms to test, such as having an AI suggest related terms). I actually...

Just adding a link to a thread for the study: Sex effects on gene expression across the human cerebral cortex at cell type resolution 2026 DeCasien et al

Here are links to some of them: General discussions Migraines caused by ME - How to discuss with Neuro? Migraine treatments Are there symptoms you had in the early stages of ME that you no longer get? - Some =477&o=date']mentions of migraine Why has 'persistent enteroviral infection' been...