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Microvascular Remodeling and Endothelial Dysfunction Across Post-COVID-19 and ME/CFS: Insights from the All Eyes on PCS Study [Line breaks added] Background Post-viral diseases, including post-COVID-19 syndrome (PCS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), cause...

I got goosebumps there. Here's the article with the apparently made up case report: Baby boy blue – why is this newborn lethargic? Rieder, Michael; Koren, Gideon Web | DOI | PMC | PDF | Paediatrics & Child Health | Open access at PMC link --------- A thesis that cites the case report...

Some posts about this trial have been moved to the thread for the trial: Trial registration: Low-dose Naltrexone for Post-COVID Fatigue Syndrome, 2022, Luis Nacul, British Columbia Women's Hospital & Health Centre

Maybe sedentary people are sedentary for a reason. Maybe more people than we thought have very mild ME/CFS or something like it.

A cross-continental comparative analysis of the neurological manifestations of Long COVID [Line breaks added] Objective To compare demographics, comorbidities, neurologic symptoms, quality of life, and cognitive outcomes among adult individuals with neurologic manifestations of post-acute...

The paper says the study was registered: The registration number given is not for a CFS study, but for a study of green tea therapy in rheumatoid arthritis: NCT03719469

Requested to be posted by @Ferry.

Epstein Barr virus, infectious mononucleosis and associated diseases as contributors to the costs of intimate kissing Ewald, Paul W. [Line breaks added] Abstract When evaluating whether kissing is an evolutionary adaptation, fitness costs and benefits need to be considered. Any disease...

Moderation note Some posts deleted in error when removing off-topic or rule breaching posts have been reinstated. Some posts discussing the deletions have been removed so as not to distract from the discussion.

I think it's almost certainly just a wrong unit since it's off by 1000 from the numbers you'd expect for count/uL. So probably should be baseline 100 count/uL in one patient and 125 count/uL in the other. I'm not sure what the plot can tell us, though.

I think the ME/CFS study also looked at the CD16+ subset: The description of which lymphocytes were tested at baseline from the protocol:

There was discussion about NK cell counts correlating to response in multiple myeloma, with the caveat that I think those studies saw correlations based on bone marrow NK cells, as opposed to blood like in the Fluge study. -...

I think it's that first each metric is considered a separate experiment with a threshold of p<.05 for the ANOVA comparing all groups at once. Then for each metric, they do 3 pairwise tests: ME/CFS-LC, ME/CFS-HC, LC-HC, so they divide the threshold by 3 to account for this. But no multiple test...

Without any healthy controls, I don't see how we can have any idea that any of this is specific to long COVID, and not just an effect of exercise.

It's a bit strange to me how consistent the results are for all five of the miRNAs they tested: They seem to have used something called fractional rank as a measure of miRNA levels. So they determine, for each participant, the rank of each miRNA. If a given miRNA species is the 25th...

Good point. Comes across a bit as just a call for donations, which people might instinctually ignore, as opposed to an informational message.

"Us" in line three is referring to everyone trying to find an answer. "Support" is ambiguous if the second part isn't just about pwME. The support a researcher, or even a caregiver, needs is very unlike the support a bedbound patient needs, so I think the sentence would be too confusing with...

Maybe we could make an S4ME branded meme/image for sharing on social media. The message seems impactful and gets across both the problem of ME/CFS and what S4ME is focused on. With slight change from: To "We" doesn't seem like it would work when talking about S4ME because there are people...

Exploring the effects of GLP-1 receptor agonists in fibromyalgia: a propensity-matched real-world cohort using TriNetX research platform Nouran Eshak, Anushka Irani, Megan Sullivan [Line breaks added] Objectives We aimed to evaluate the effects of GLP-1 receptor agonists (GLP-1RA) on symptom...