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JAMA Medical News in Brief: "Resistance Training Improves Long COVID Outcomes"

It's confusing because isn't the full amount needed something like 26,000,000 NOK? Does raising this 4,000,000 complete the full amount?

I think one thing I would have liked to see is a negative control for the transcranial stimulation portion, where they stimulated other areas to confirm that it is indeed stimulation of specifically the right inferior insula that leads to a reduced false alarm rate.

A region-specific brain dysfunction underlies cognitive impairment in long COVID brain fog [Line breaks added] Abstract Long COVID "brain fog" is a common and debilitating subjective syndrome often associated with persistent cognitive impairment after COVID-19 infection. Here we identify a...

Just double checking something if you want to share: are you saying the amount your HR increases versus resting is very high compared to a healthy person, or is it substantially higher all the time, and the increase from being on your phone is fairly minimal? Edit: Either way, I think that is...

Oh I hadn't realized the paper you linked was the same one mentioned in the blog. I'm not entirely sure. I think they did both the GREML algorithm and more traditional pedigree-based estimates. I'm confused because the chart in the blog shows a bar for twin-based heritability in Wainschtein...

I think the point of the blog is that the algorithms in recent studies are considered to be relatively 'complete' pictures of heritability. Here are the three main algorithms being discussed, which converged on similar estimates and found that heritability was far below what twin studies were...

Very interesting. The details of how the more accurate heritability algorithms work are beyond me. But the blog is saying that twin studies likely almost always far overestimate heritability due to shared environment. Maybe proving Jonathan correct:

Thanks for the counter examples. I think worth at least a look. Maybe if people do end up improving from dara and they run more trials based on step count and subjective scales, they could measure heart rate as well and see how much it correlates to the other metrics.

Thanks, maybe this would in fact show a disconnect between HR and the types of exertion that can lead to PEM. For this scenario, step count presumably wouldn't be a good indicator either since it would be the same number of steps. Yet people use step count for trying to get a rough measure of...

Good point about the beta blocker. Heart rate wouldn't be considered a direct measure of exertion, it would just be a proxy marker. If you take a beta blocker to decrease the correlation between exertion and heart rate, then it wouldn't act as a good proxy anymore. Any studies that used this...

Yes, it's very simple: mild people's hearts would beat more times throughout the day because they are participating in more exertion than severe people. Only slightly more complicated when considering only those heart beats that are in excess of resting heart beats to normalize between people.

Could you give an example(s) of what you mean? For example, in the dara trial, I'm suggesting that average heart rate might have better captured how much more people were actually doing, versus average step count. And insofar as we can at least get a rough idea of a person's severity from...

I think the disconnect might be that you're talking about a simple difference between resting heart rate and maximum heart rate during the day. I'm talking about averages. If you get your HR up to 150 bpm for a minute, that won't increase your average bpm as much as increasing to 90 bpm for an...

I'm wondering whether average heart rate, acting as a measure of total exertion, might be a good measure of ME/CFS severity. Step count and upright time don't really disambiguate between type of activity performed. For example, slow walking, normal walking, and running all count the same when...

Association of Long COVID-Related inflammatory Processes in the Musculoskeletal System: 12-Month Longitudinal Cohort Feasibility Study Background A subset of individuals develops persistent symptoms following SARS-CoV-2 infection, including musculoskeletal (MSK) manifestations, a condition...

Differential Characteristics and Comparison Between Long-COVID Syndrome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Abstract Long-COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome are disabling diseases characterised by ongoing fatigue, post-exertional malaise...

Reduced prepulse inhibition associated with fibromyalgia in two studies. It might be good to test this in ME/CFS. Alterations in excitatory and inhibitory brainstem interneuronal circuits in fibromyalgia: Evidence of brainstem dysfunction, 2014, Kofler et al Web | DOI | Clinical...

It seems to me like "10 years" refers to the span between the 1998 study and this study:

It took 16 years to analyze and publish?