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Altered brain tissue microstructure and neurochemical profiles in long COVID and recovered COVID-19 individuals: A multimodal MRI study [Line breaks added] Background Diverse neurological symptoms are experienced by long COVID and COVID-19 recovered individuals. However, the long-term...

Posted on behalf of another user.

T cell-driven sustained inflammation and immune dysregulation mimicking immunosenescence for up to three years post-COVID-19 [Line breaks added] Abstract Long COVID has emerged as a major global health concern, yet the long-term trajectory of immune recovery and its contribution to...

Extracellular vesicles from long COVID patients promote RUNX2-mediated cellular stress via dysregulated miR-204 and p53 pathway activation [Line breaks added] Background: Subjects with Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC)...

Maybe I'm misunderstanding. Do you mean ~50% of the 17 participants in the study were misdiagnosed by the investigators? I don't recall anything in the paper suggesting that.

What's this based on?

From the newest comment: I assume they meant there was no evidence of increased PEM. There was clearly evidence of PEM: Also, as I highlighted before: 1. There's no baseline data, so they can't say there's no increase. 2. Even if they assume the groups were equal at baseline, a lack of...

I haven't read this, but just noticed WASF3:

A post about an abstract has been moved to its own thread: Single cell epigenomic profiling identifies a distinct classical monocyte subset driving inflammation in ME/CFS, 2025, Iu et al

Autonomic dysfunction and vasoregulation in Long COVID-19 are linked to anti-GPCR autoantibodies [Line breaks added] Background SARS-CoV-2-triggered autoantibodies (AAB) targeting G protein-coupled receptors (GPCRs) have been suggested to contribute to the post-acute sequelae of COVID-19...

JAMA Medical News in Brief: "Resistance Training Improves Long COVID Outcomes"

It's confusing because isn't the full amount needed something like 26,000,000 NOK? Does raising this 4,000,000 complete the full amount?

I think one thing I would have liked to see is a negative control for the transcranial stimulation portion, where they stimulated other areas to confirm that it is indeed stimulation of specifically the right inferior insula that leads to a reduced false alarm rate.

A region-specific brain dysfunction underlies cognitive impairment in long COVID brain fog [Line breaks added] Abstract Long COVID "brain fog" is a common and debilitating subjective syndrome often associated with persistent cognitive impairment after COVID-19 infection. Here we identify a...

Just double checking something if you want to share: are you saying the amount your HR increases versus resting is very high compared to a healthy person, or is it substantially higher all the time, and the increase from being on your phone is fairly minimal? Edit: Either way, I think that is...

Oh I hadn't realized the paper you linked was the same one mentioned in the blog. I'm not entirely sure. I think they did both the GREML algorithm and more traditional pedigree-based estimates. I'm confused because the chart in the blog shows a bar for twin-based heritability in Wainschtein...

I think the point of the blog is that the algorithms in recent studies are considered to be relatively 'complete' pictures of heritability. Here are the three main algorithms being discussed, which converged on similar estimates and found that heritability was far below what twin studies were...

Very interesting. The details of how the more accurate heritability algorithms work are beyond me. But the blog is saying that twin studies likely almost always far overestimate heritability due to shared environment. Maybe proving Jonathan correct:

Thanks for the counter examples. I think worth at least a look. Maybe if people do end up improving from dara and they run more trials based on step count and subjective scales, they could measure heart rate as well and see how much it correlates to the other metrics.

Thanks, maybe this would in fact show a disconnect between HR and the types of exertion that can lead to PEM. For this scenario, step count presumably wouldn't be a good indicator either since it would be the same number of steps. Yet people use step count for trying to get a rough measure of...